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Anti-CHGA Antibody (2Q520)
还可以产品编号 TMAY-00102
Anti-CHGA Antibody (2Q520) 是一种 Rabbit 抗体，靶向 CHGA。Anti-CHGA Antibody (2Q520) 可用于 IHC-P。
Anti-CHGA Antibody (2Q520)
Anti-CHGA Antibody (2Q520)
还可以产品编号 TMAY-00102
Anti-CHGA Antibody (2Q520) 是一种 Rabbit 抗体，靶向 CHGA。Anti-CHGA Antibody (2Q520) 可用于 IHC-P。
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抗原信息
| 产品描述 | Anti-CHGA Antibody (2Q520) is a Rabbit antibody targeting CHGA. Anti-CHGA Antibody (2Q520) can be used in IHC-P. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 2Q520 |
| 交叉反应 | Human |
| 验证活性 | 1. Immunochemical staining of human Chromogranin A in human pancreas with rabbit monoclonal antibody (1:2000, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human Chromogranin A in human adrenal gland with rabbit monoclonal antibody (1:2000, formalin-fixed paraffin embedded sections). |
| 应用 | IHC-P |
| 推荐剂量 | IHC-P: 1:1000-1:4000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with a synthetic peptide corresponding to the center region of the Human Chromogranin A/CHGA/CGA. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | The acidic glycoprotein chromogranin A (CHGA) is co-stored/co-secreted with catecholamines and crucial for secretory vesicle biogenesis in neuronal/neuroendocrine cells. CHGA is dysregulated in several cardiovascular diseases, but the underlying mechanisms are not well established. The CHGA promoter haplotype 2 (occurring in a large proportion of the world population) in enhancing CHGA expression in haplotype 2 carriers who may be at higher risk for cardiovascular/metabolic disorders. Chromogranin A (CHGA) plays a fundamental role in the biogenesis of catecholamine secretory granules. Changes in storage and release of CHGA in clinical and experimental hypertension prompted us to study whether genetic variation at the CHGA locus might contribute to alterations in autonomic function, and hence hypertension and its target organ consequences such as hypertensive renal disease (nephrosclerosis). Chromogranin A (CHGA) plays a catalytic role in formation of catecholamine storage vesicles and also serves as precursor to the peptide fragment catestatin, a catecholamine secretory inhibitor whose expression is diminished in the hypertensive individuals. The chromogranin/secretogranin proteins are costored and coreleased with catecholamines from secretory vesicles in chromaffin cells and noradrenergic neurons. Chromogranin A (CHGA) regulates catecholamine storage and release through intracellular (vesiculogenic) and extracellular (catecholamine release-inhibitory) mechanisms. CHGA is a candidate gene for autonomic dysfunction syndromes, including intermediate phenotypes that contribute to human hypertension. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide corresponding to the center region of the Human Chromogranin A/CHGA/CGA |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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