cga

Trifloxystrobin metabolite CGA-321113 (Standard) 是一种可用于分析的标准物质，通常用作 Trifloxystrobin metabolite CGA-321113 的研究和分析中参考的标准样品。Trifloxystrobin metabolite CGA-321113 是一种肟菌酯的酸代谢产物，具有抗真菌活性。

CGA-JK3 is an IkappaB kinase inhibitor in innate immune process.

Triclabendazole (CGA89317) 是一种苯并咪唑，与微管蛋白结合，损害细胞内运输机制，且干扰蛋白质的合成。

Metalaxyl (CGA 48988) 是一种被广泛使用的杀真菌剂，可抑制真菌中的蛋白质合成，干扰斑马鱼胚胎的骨骼发育，可用于控制由卵菌真菌引起的植物病害。

Cyromazine (CGA-72662) 是三聚氰胺的环丙基衍生物，是昆虫生长调节剂，用作杀虫剂和杀螨剂，通过影响某些昆虫幼虫阶段的神经系统而起作用。

Fludioxonil (CGA 173506) 是一种苯基吡咯类杀菌剂，可抑制草莓和黑莓作物中灰霉病菌的生长。

Pymetrozine (CGA 215944)是一种针对Homoptera的喂养抑制剂，能有效防止通过蚜虫Myzus persicae传播cauliflower mosaic caulimovirus。

Trifloxystrobin (CGA 279202) 是一种杀菌剂，可抑制从甜菜作物中分离出的立枯病菌的生长。对大型水蚤新生儿和胚胎的 EC50 分别为 23.0 μg L 和 1.7 μg L。

Profluralin is a effective herbicide.

Nitroscanate is an anthelmintic found to be effective in certain strains of parasites in canines.

NE97220 is a bioactive chemical.

Fludioxonil 用于控制烟草植株顶切后腋芽（吸芽）的生长。其作用方式为局部系统效应、接触作用及植物毒性。

3-Aminopropylphosphinic acid (3-APPA) is a phosphonic analog of gamma-aminobutyric acid (GABA). It acts as a potent and selective agonist of the GABA B receptor.

Cymiazole is an agent of biochemical.

Chlorfluazuron, a chitin synthesis inhibitor, is commonly used as an insect growth regulator for controlling the major insect pests in crops.

2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) 是细胞天然免疫中第二信使，在 DNA 结合条件下由 cGAMP 合成酶 (cGAS) 催化形成。2',3'-cGAMP sodium 可与 STING 结合形成二聚体，诱导 IFN-β 及其他细胞因子的产生和表达。

2',3'-cGAMP (2'-3'-cyclic GMP-AMP) 是细胞天然免疫中第二信使，在DNA结合条件下由 cGAMP 合成酶 (cGAS) 催化形成。2',3'-cGAMP 可与 STING 结合形成二聚体，诱导干扰素-β（IFN-β）及其他细胞因子的产生和表达。

3'3'-cGAMP is a second messenger produced in bacteria by specific dinucleotide cyclases. It contains canonical 3'5'-phosphodiester bonds and regulates chemotaxis, colonization, and other cellular functions. 3'3'-cGAMP shows weaker binding to the adapter protein stimulator of interferon genes (STING; Kd = 1.04 μM) than 2'2'-cGAMP and 2'3'-cGAMP but has similar binding affinity to 3'2'-cGAMP (Kd = 1.61 μM) and cyclic di-GMP . 3'3'-cGAMP induces IFN-β mRNA expression in L929 cells (EC50 = 40.5 nM).

cGAMP (Cyclic GMP-AMPP) diammonium 是一种内源性第二信使，通过触发干扰素的产生来响应胞浆 DNA。它通过激活干扰素基因刺激因子（STING），启动信号级联，进而导致I型干扰素及其他免疫介质的生成。

2'2'-cGAMP is a synthetic dinucleotide (CDN) that contains non-canonical 2'5'-phosphodiester bonds. It binds to the adapter protein stimulator of interferon genes , which is a component of the innate immune response that activates the type I interferon pathway when bound to cyclic dinucleotides. 2'2-cGAMP shows weaker binding to STING than 2'3'-cGAMP but binds more strongly than 3'3'-cGAMP , cyclic di-GMP , or 3'2'-cGAMP, which bind in the micromolar range (Kds = 1.04, 1.21, or 1.61 μM, respectively). Despite weaker binding, 2'2'-cGAMP induces IFN-β production in the same concentration range as 2'3'-cGAMP (EC50s = 15.8 and 19.4 nM, respectively, in L929 cells).

2', 3'-cGAMP-C2-SH is a ADC cytotoxin.

Mal-Val-Ala-PABA-cGAMP 是一款 ADC 连接剂，适用于与 STING 激动剂的结合。该化合物主要用于合成抗体-活性分子偶联物（ADCs）。

cGAS-IN-4 (Compound 36) 是一种口服有效的环状 GMP-AMP 合酶 (cGAS) 抑制剂，对 h-cGAS 和 m-cGAS 的 IC50 分别为 32 nM 和 5.8 nM。在 THP-1 cell 细胞中，cGAS-IN-4 以 IC50 为 60 nM 抑制 cGAMP，从而提高细胞效能。在小鼠模型中，该化合物对 Concanavalin A 诱发的急性肝损伤展现抗炎作用。

2',3'-cGAMP-C2-PPA (45) is a cyclic di-nucleotide that acts as a STING agonist (US20210015941A1). It is a drug-linker conjugate for antibody-drug conjugates (ADC) used in the targeted treatment of cancer.