Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sulindac sulfone 是非甾体抗炎药舒林酸 (sulindac) 的代谢物。 它是醛糖还原酶的抑制剂 (IC50 =367 nM)。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 287 | 现货 | ||
10 mg | ¥ 428 | 现货 | ||
25 mg | ¥ 735 | 现货 | ||
50 mg | ¥ 1,098 | 待询 | ||
100 mg | ¥ 1,653 | 待询 | ||
200 mg | ¥ 2,479 | 待询 | ||
1 mL * 10 mM (in DMSO) | ¥ 387 | 现货 |
产品描述 | Sulindac sulfone is a metabolite of the nonsteroidal anti-inflammatory drug sulindac. Sulindac sulfone is an inhibitor of aldose reductase (IC50 =367 nM). |
靶点活性 | Aldose reductase:367 nM |
体外活性 | In vitro: Sulindac sulfone treatment also inhibited PGE2 production by HCA-7 cells with an IC50 of 360 mmol/L. Sulindac sulfone at 100 mmol/L reduced 6-ketoPGFα by 29.2%. Sulindac sulfone reduced the colony number of HCA-7 and HCT-116 with an EC50 of 50 mmol/l. Sulindac sulfone significantly decreased the expression of total cellular β-catenin (50% of control), pro-caspase 3 (49%), cyclin D1 (51%), and PPARδ (65%) in SW480 cells. No significant alteration in pro-caspase 3 or β-catenin expression was found in HCA7, LS174, or Caco-2 cells treated with sulindac sulfone. A dose-dependent reduction in TCF-mediated transcriptional activity was also observed in SW480 cells [1][2]. |
体内活性 | In vivo: Sulindac sulfone is capable of reducing the incidence, multiplicity, and tumor burden in the azoxymethane AOM rat model of colorectal cancer. Sulindac sulfone had no effect on the growth of HCA-7, HCT-116 xenografts, and cancer cell xenografts [1]. |
分子量 | 372.41 |
分子式 | C20H17FO4S |
CAS No. | 59864-04-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 2.54 mg/mL
DMSO: > 9.53 mg/mL, Sonication and heating are recommended.
Ethanol: > 3.83 mg/mL, Sonication and heating are recommended.
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Sulindac sulfone 59864-04-9 Endocrinology/Hormones Immunology/Inflammation Metabolism Neuroscience Reductase COX Aldose Reductase inhibit Exisulind Inhibitor inhibitor