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Streptomycin sulfate

Streptomycin sulfate

产品编号 T0060   CAS 3810-74-0
别名: Phytomycin, Plantomycin, Estreptomicina, 硫酸链霉素

Streptomycin sulfate 是一种能抑制蛋白质合成的氨基糖苷类抗生素。

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Streptomycin sulfate, CAS 3810-74-0
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产品目录号及名称: Streptomycin sulfate (T0060)
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天然产物信息
生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 Streptomycin sulfate is a sulfate salt of streptomycin that is a protein synthesis inhibitor.
体外活性 Strain RB1 shows enhanced susceptibility to streptomycin as the concentration of CV in the growth medium increases. Both cytochrome aa3 levels and streptomycin susceptibility increase as the CV concentration in the growth medium increases. Cytochrome aa3 is necessary for accumulation of streptomycin by B. subtilis[1]. Streptomycin influences tRNA selection. Streptomycin resistance mutations generally map to protein S12 and most of these variants exhibit increased levels of discrimination in the tRNA selection process[2].
别名 Phytomycin, Plantomycin, Estreptomicina, 硫酸链霉素
分子量 1457.38
分子式 2C21H39N7O12·3H2SO4
CAS No. 3810-74-0

存储

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

溶解度

H2O: 10 mM

DMSO: Insoluble

( < 1 mg/mL refers to the product slightly soluble or insoluble )

参考文献

1. McEnroe AS, et al. Correlation between cytochrome aa3 concentrations and streptomycin accumulation in Bacillus subtilis. Antimicrob Agents Chemother. 1984 Oct;26(4):507-12. 2. Sharma, D., et al., Mutational analysis of S12 protein and implications for the accuracy of decoding by the ribosome. J Mol Biol, 2007. 374(4): p. 1065-76. 3. Zhai J, Jiang C, Long C. Two‐step Method for the Construction and Start‐up of a Fungal‐Bacterial Biofilter for Treating Gaseous Toluene[J]. Environmental Progress & Sustainable Energy. 2020: e13404. 4. Mo L, Hong S, Li Y, et al. Sevoflurane inhibited inflammatory response induced by TNF-α in human trophoblastic cells through p38MAPK signaling pathway[J]. Journal of Receptors and Signal Transduction. 2020: 1-6. 5. Li Q, Bian Y, Li Q. Down-Regulation of TMPO-AS1 Induces Apoptosis in Lung Carcinoma Cells by Regulating miR-143-3p/CDK1 Axis[J]. Technology in cancer research & treatment. 2021, 20: 1533033820948880. 6. Huang L, Li Q. Notoginsenoside R1 promotes differentiation of human alveolar osteoblasts in inflammatory microenvironment through inhibiting NF‑κB pathway and activating Wnt/β‑catenin pathway[J]. Molecular Medicine Reports. 2020, 22(6): 4754-4762.

文献引用

1. Qu H, Yu Q, Jia B, et al. HIF‑3α affects preeclampsia development by regulating EVT growth via activation of the Flt‑1/JAK/STAT signaling pathway in hypoxia. Molecular Medicine Reports. 2021, 23(1): 1-1. 2. Huang L, Li Q. Notoginsenoside R1 promotes differentiation of human alveolar osteoblasts in inflammatory microenvironment through inhibiting NF‑κB pathway and activating Wnt/β‑catenin pathway. Molecular Medicine Reports. 2020, 22(6): 4754-4762 3. Li Q, Bian Y, Li Q. Down-Regulation of TMPO-AS1 Induces Apoptosis in Lung Carcinoma Cells by Regulating miR-143-3p/CDK1 Axis. Technology in cancer research & treatment. 2021, 20: 1533033820948880. 4. Mo L, Hong S, Li Y, et al. Sevoflurane inhibited inflammatory response induced by TNF-α in human trophoblastic cells through p38MAPK signaling pathway. Journal of Receptors and Signal Transduction. 2020: 1-6 5. Zhai J, Jiang C, Long C. Two‐step Method for the Construction and Start‐up of a Fungal‐Bacterial Biofilter for Treating Gaseous Toluene. Environmental Progress & Sustainable Energy. 2020: e13404 6. Zhang Y, Cai Y, Wang T, et al.A common tolerance mechanism of bacterial biofilms to antibiotics.bioRxiv.2023: 2023.01. 30.526163.
Tigecycline Azithromycin hydrate Clarithromycin Doxycycline Puromycin dihydrochloride Lincomycin hydrochloride monohydrate Chloramphenicol Kanamycin sulfate

相关化合物库

该产品包含在如下化合物库中:
FDA 上市药物库 天然产物库 共价抑制剂库 NO PAINS 化合物库 抗生素库 NMPA中国上市药物库 高通量筛选天然产物库 临床期小分子药物库 抗感染化合物库 上市药物库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% ddH2O
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计算器

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稀释计算器
配液计算器
分子量计算器
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输入分子式,点击计算,可计算出产品的分子量。

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技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Streptomycin sulfate 3810-74-0 Microbiology/Virology ribosome Antibacterial Antibiotic Bacterial Inhibitor Streptomycin Phytomycin inhibit Plantomycin Estreptomicina 硫酸链霉素 inhibitor

 

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