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S 38093

产品编号 T4099 CAS 862896-30-8

别名: S38093, S-38093

S 38093 是一种可透过大脑的，可口服的组胺 H3 受体拮抗剂，对大小鼠和人的 H3 受体具有不同的亲和力，Ki 值分别为 8.8、1.44 和 1.2 µM。

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S 38093, CAS 862896-30-8

规格	价格/CNY	货期
1 mg	￥ 398	现货
2 mg	￥ 543	现货
5 mg	￥ 747	现货
10 mg	￥ 957	现货
25 mg	￥ 1,820	现货
50 mg	￥ 3,230	现货
100 mg	￥ 4,770	现货
1 mL * 10 mM (in DMSO)	￥ 758	现货

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其他形式的 S 38093:

S 38093 HCl
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生物活性

化学信息

存储 & 溶解度

参考文献

相关产品

产品描述	S 38093 is a brain-penetrant antagonist of the H3 receptor (Ki: 8.8/1.44/1.2 μM, for rat/mouse/human).
靶点活性	H3 receptor (mouse):1.44 μM(Ki), H3 receptor (rat):8.8 μM(Ki), H3 receptor (human):1.2 μM(Ki)
体外活性	In cellular models, S 38093 can antagonize mice H3 receptors (KB: 0.65 μM) and suppress cAMP decrease induced by an H3 agonist (KB: 0.11 μM). In cells expressing a high H3 density, S 38093 is a moderate inverse agonist at the rat and human H3 receptors (EC50: 9/1.7 μM, respectively)[2].
体内活性	In young adult mice, S 38093 (0.3/3?mg/kg/day, p.o., 28 days) markedly increases proliferation of progenitors in the DG of the hippocampus. S 38093 (0.3?mg/kg/day) markedly increases the number of DCX+?cells with tertiary dendrites. S 38093 (0.3/1/3?mg/kg) markedly increases cell survival, proliferation, and maturation in the DG of the hippocampus in aged mice relative to the vehicle. S 38093 (3?mg/kg/day, p.o., 28 days) increases cell proliferation and has a strong effect on cell survival, also increases the dendritic intersections in both genotypes, with a significant effect from 50 to 80 in APPSWETG?mice only. In aged mice, chronic administration of S 38093 (1/3?mg/kg/day, p.o., 28 days) reverses this age-dependent decrease in BDNF-IX/IV/I transcripts. In addition, S 38093 at three tested doses (0.3/1/3?mg/kg/day) increases VEGF transcripts compared to the vehicle-aged group[1].
动物实验	S 38093 is formulated in purified water.The context discrimination task consists of an 8-day contextual fear discrimination paradigm in which the mice have to learn to distinguish between a fearful shock context and a similar non-shock context. On day 1 the mice are only exposed to the training shock context, and on days 2-8 the mice are exposed to the shock and then non-shock context in that order each day. The mice are run through the context discrimination task starting at 10 am and ending at 2 pm and are then gavaged with vehicle or S 38093 at 4 pm each day. The drug and vehicle are always administered after behavioral testing to avoid possible acute effects of the drug on behavior. Learning is measured by the percent time the mice spent freezing and testing is terminated when percent freezing is consistently significantly different between the two contexts. The mice are tested after 29 days of drug treatment. Conditioning is conducted on one side of a Med-Associates shuttle box (ENV-010MC; 20.3?cm?×?15.9?cm?×?21.3?cm high) with a clear plexiglass wall, 3 aluminum walls and a stainless steel grid as a floor. Mouse behavior is recorded by digital video cameras mounted above the conditioning chamber. In training context A, mice are allowed to habituate in new cages outside the room and are then brought into the room in the new cages. The house fan and house light are turned on, the stainless steel grid is exposed, the plexiglass wall is up and a mild anise scent is used as an olfactory cue. The door to the sound dampening enclosure is shut for the duration of the trial. 180?s after the mice are placed in the training context, they are delivered a single footshock of 0.75?mA lasting 2?s. 15?s after the end of the footshock, the mice are placed back into their home cages. Non-alcoholic antiseptic wipes are used to clean the grids and catch trays in between trials. An hour later the mice are brought into the room in paper buckets and put into similar context B.The house fan and house light are turned off, the door of the enclosure is left ajar, plastic placemat sheets are put into the shuttle box to make a high-walled circular enclosure, the plexiglass wall is left down and a mild lemon scent is used as the olf

别名	S38093, S-38093
分子量	288.38
分子式	C17H24N2O2
CAS No.	862896-30-8

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 55 mg/mL (190.72 mM)

溶液配制表

可选溶剂	浓度体积质量	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.4676 mL	17.3382 mL	34.6765 mL	86.6912 mL
	5 mM	0.6935 mL	3.4676 mL	6.9353 mL	17.3382 mL
	10 mM	0.3468 mL	1.7338 mL	3.4676 mL	8.6691 mL
	20 mM	0.1734 mL	0.8669 mL	1.7338 mL	4.3346 mL
	50 mM	0.0694 mL	0.3468 mL	0.6935 mL	1.7338 mL
	100 mM	0.0347 mL	0.1734 mL	0.3468 mL	0.8669 mL

计算器

摩尔浓度计算器

稀释计算器

配液计算器

分子量计算器

质量

浓度

容积

分子量

浓度 (起始)

容积 (起始)

浓度 (终)

容积 (终)

溶液体积

质量

配液浓度

参考文献

1. Guilloux JP, et al. S 38093, a histamine H3 antagonist/inverse agonist, promotes hippocampal neurogenesis and improves context discrimination task in aged mice. Sci Rep. 2017 Feb 20;7:42946. 2. Sors A, et al. Mechanistic characterization of S 38093, a novel inverse agonist at histamine H3 receptors. Eur J Pharmacol. 2017 May 15;803:11-23

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

剂量

mg/kg

每只动物体重

给药体积

μL

动物数量

第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

计算重置

计算结果如下:

工作液浓度: mg/ml;

母液配置方法: mg 药物溶于 μL DMSO (母液浓度为 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 μL DMSO 主液，加入 μL PEG300，混匀澄清，再加 μL Tween 80，混匀澄清，再加 μL ddH₂O, 混匀澄清。

备注:

要按顺序从左向右依次添加助溶剂。可配合物理方法，如涡流、超声波或热水浴使之帮助溶解。

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到，包括如何准备库存溶液，如何存储产品，以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

S 38093 862896-30-8 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor inhibit S38093 S-38093 Inhibitor inhibitor

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S 38093

存储

溶解度

溶液配制表

计算器

输入分子式，点击计算，可计算出产品的分子量。

参考文献

相关产品

相关化合物库

剂量换算

体内实验配液计算器

技术支持

Keywords