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Pirarubicin

Pirarubicin

产品编号 T6628   CAS 72496-41-4
别名: 吡柔比星, Theprubicin, THP

Pirarubicin 是一种蒽环类抗生素,是拓扑异构酶 II 抑制剂,可用于各种癌症的研究。

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Pirarubicin, CAS 72496-41-4
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产品目录号及名称: Pirarubicin (T6628)
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纯度: 98.66%
纯度: 98.27%
纯度: 97.61%
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生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 Pirarubicin is an anthracycline antibiotic. It is also a DNA/RNA synthesis inhibitor that intercalates into DNA and interacts with topoisomerase II, utilized as an antineoplastic agent.
体外活性 Pirarubicin is rapidly taken up by M5076 cells and the intracellular concentration of pirarubicin reaches more than 2.5-fold that of doxorubicin. Pirarubicin is more effective than doxorubicin in terms of the 50% cell growth-inhibitory concentration in vitro. [1] Pirarubicin causes G0/G1 cell cycle arrest in MG-63 cells. Pirarubicin suppresses the expression of PCNA, cyclin D1, cyclin E and Bcl-2, and increases Bax expression in MG-63 cells. [2] Pirarubicin markedly relaxes contractions induced by noradrenaline (0.1 μM) in the aorta with endothelium, but not in that without endothelium. Pirarubicin-induced relaxation is inhibited by methylene blue (5 μM), hydroquinone (100 μM), phenidone (50 μM), haemoglobin (1 μM) and p-bromophenacyl bromide (50 μM), but not by indomethacin (25 μM). [3] Pirarubicin is approximately 2-5 times more potent than Adriamycin in SKUT1B, HEC1A, and BG1 cell lines. Pirarubicin also displays a reverse dose-response pattern of G2 block so that at high dose, cell cycle kinetics would mirror those of untreated controls. [4]
体内活性 Pirarubicin reduces the tumor weight to 60% of the control level in M5076 solid tumor-bearing mice, although doxorubicin has no effect. [1] Pirarubicin and Epirubicin are effective against V x 2 tumor when injected via the hepatic intra-arterial (h.i.a.) route, the activity of Pirarubicin is stronger than that of Epirubicin. [5]
别名 吡柔比星, Theprubicin, THP
分子量 627.64
分子式 C32H37NO12
CAS No. 72496-41-4

存储

 | Powder: -20°C for 3 years | In solvent: -80°C for 2 years

溶解度

Ethanol: <1 mg/mL

H2O: <1 mg/mL

DMSO: 7 mg/mL (11.15 mM)

( < 1 mg/mL refers to the product slightly soluble or insoluble )

参考文献

1. Sugiyama T, et al. Jpn J Cancer Res, 1999, 90(7), 775-780. 2. Liu SY, et al. Chemotherapy, 2010, 56(2), 101-107. 3. Hirano S, et al. J Pharm Pharmacol, 1991, 43(12), 848-854. 4. Nguyen HN, et al. Gynecol Oncol, 1992, 45(2), 164-173. 5. Okada M, et al. Br J Cancer, 1995, 71(3), 518-524. 6. Li K, et al. Pirarubicin induces an autophagic cytoprotective response through suppression of the mammalian target of rapamycin signaling pathway in human bladder cancer cells. Biochem Biophys Res Commun. 2015 May 1;460(2):380-5. 7. Wang YD, et al. Cardioprotective effects of rutin in rats exposed to pirarubicin toxicity. J Asian Nat Prod Res. 2017 Oct 27:1-13.

文献引用

1. Cheng M Z, Yang B B, Zhan Z T, et al.MACC1 and Gasdermin-E (GSDME) regulate the resistance of colorectal cancer cells to irinotecan.Biochemical and Biophysical Research Communications.2023
Alalevonadifloxacin Pegamotecan Aldoxorubicin hydrochloride 9-Hydroxycamptothecin Exatecan Trovafloxacin Voreloxin Aldoxorubicin

相关化合物库

该产品包含在如下化合物库中:
上市药物库 抗感染化合物库 抗肝癌化合物库 药物功能重定位化合物库 抗癌化合物库 人代谢物化合物库 经典已知活性库 抗癌药物库 自噬库 抗癌临床化合物库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% ddH2O
计算 重置

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
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X
X
X
=
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g/mol

输入分子式,点击计算,可计算出产品的分子量。

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技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Pirarubicin 72496-41-4 Autophagy DNA Damage/DNA Repair Microbiology/Virology Topoisomerase Antibacterial Antibiotic Bacterial inhibit Inhibitor 吡柔比星 Theprubicin THP inhibitor

 

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