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Search Results for " vimentin "

Targets Recommended: Apoptosis Phosphatase Gamma-secretase Immunology/Inflammation related

6

抑制剂 & 化合物

1

天然产物

6

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T13410	ZLDI-8	Apoptosis; Phosphatase; Gamma-secretase; Immunology/Inflammation related	Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience; Proteases/Proteasome; Stem Cells
	ZLDI-8 是 Notch 激活/裂解酶 ADAM-17 的抑制剂，可抑制 Notch 蛋白裂解，并降低促存活/抗凋亡和上皮-间质转化相关蛋白的表达。它还是竞争性不可逆酪氨酸磷酸酶抑制剂，以IC50为 5.32 μM 抑制 MHCC97-H 细胞的生长。
T9657	FiVe1	Others	Others
	FiVe1是一种波形蛋白结合小分子，在中期促进波形蛋白解体和磷酸化，导致有丝分裂灾难，多核化和癌细胞干性丧失；选择性地和不可逆地抑制间充质转化的乳腺癌细胞（FOXC2-HMLER 细胞IC50=234nM）和不同组织学亚型的软组织肉瘤的生长。
T61746	Anticancer agent 82
	Anticancer agent 82 是 FiVe1 衍生物，是一种口服有效的选择性抗癌剂。FiVe1 能够结合 III 型中间丝蛋白vimentin(VIM)，诱导 Ser56 过度磷酸化，导致有丝分裂的选择性中断和转化表达 VIM 的间充质癌细胞的多核化。Anticancer agent 82 比 FiVe1 表现出更好的口服利用度和药代动力学特征。
T22036	Arylquin 1
	Arylquin 1 是一种前列腺-凋亡-反应-4(Par-4)促分泌剂，靶向波形蛋白诱导 Par-4 分泌。Arylquin 1 通过诱导溶酶体膜通透性 (LMP) 诱导癌细胞非凋亡性细胞死亡。
T82006	JM3A
	JM3A为高特异性生物活性肽，针对早期肺癌细胞转化过程中新表达的细胞表面波形蛋白(CSV)。通过与荧光团耦合，JM3A能够检测并标记CSV。
T81400	Pritumumab
	Pritumumab是一种自然源的人类IgG1kappa单克隆抗体，其最初源于一位宫颈癌患者的区域淋巴结分离得到。该单抗特异性地识别波形蛋白，该蛋白在多种恶性肿瘤细胞表面展现。Pritumumab在胶质母细胞瘤的科研应用中具有潜在价值。

化合物

Cat.No: T13410

Target: Apoptosis, Phosphatase, Gamma-secretase, Immunology/Inflammation related

Cat.No: T9657

Target: Others

Anticancer agent 82

Cat.No: T61746

Cat.No: T22036

Cat.No: T82006

Cat.No: T81400

Cat. No.	Product Name	Target	Signaling Pathways
T75491	3-(2-Hydroxyethyl) thio withaferin A
	3-(2-Hydroxyethyl) thio withaferin A 为Withaferin A衍生物，后者为甾体内酯，能够抑制NF-kB活性并靶向波形蛋白(vimentin)，展现出抗炎及抗肿瘤效果。此外，Withaferin A亦为内皮蛋白C受体(EPCR)脱落的抑制剂。

天然产物

3-(2-Hydroxyethyl) thio withaferin A

Cat.No: T75491

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04329	Vimentin Protein, Human, Recombinant (His) CTRCT30,HEL113,vimentin	Human	Baculovirus Insect Cells
	Vimentin is a type III intermediate filament (IF) protein found in various non-epithelial cells, especially mesenchymal cells. A vimentin monomer, has a central α-helical domain and carboxyl (tail) domains. Two monomers compose the basic subunit of vimentin assembly. Vimentin is crucial for supporting and anchoring the position of the organelles in the cytosol. Vimentin provided cells with a resilience absent from the microtubule or actin filament networks, when under mechanical stress in vivo. ...
TMPH-02971	Vimentin Protein, Mouse, Recombinant (His & Myc)	Mouse	HEK293 Cells
	Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.; Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. Vimentin Protein, Mouse, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predicted molecular weight is 58.6 kDa and the accession number i...
TMPH-02970	Vimentin Protein, Mouse, Recombinant (E. coli, His & Myc)	Mouse	E. coli
	Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.; Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. Vimentin Protein, Mouse, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 61.0 kDa and the access...
TMPK-01299	CEACAM5 Protein, Cynomolgus, Recombinant (aa 35-685, His) Carcinoembryonic,CEA,CEACD66e,DKFZp781M2392,CEACAM-5,CD66e,M...	Cynomolgus	HEK293 Cells
	Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) was identified as a metastatic driver. CEACAM5 overproduction enriched for an epithelial gene expression pattern and facilitated tumor outgrowth at metastatic sites. Tissues from patients with metastatic breast cancer confirmed elevated levels of CEACAM5 in lung metastases relative to breast tumors, and an inverse correlation between CEACAM5 and the mesenchymal marker vimentin was demonstrated.
TMPH-01752	Nestin/NES Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells. Nestin/NES Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 2...
TMPJ-00846	GFAP Protein, Human, Recombinant (His) Glial Fibrillary Acidic Protein,GFAP	Human	E. coli
	Glial Fibrillary Acidic Protein (GFAP) is an intermediate filament (IF) protein which belongs to the intermediate filament family. GFAP is expressed in numerous cell types of the central nervous system (CNS), ependymal cells and phosphorylated by PKN1. GFAP, a class-III intermediate filament, is a cell-specific marker during the development of the central nervous system and distinguishes astrocytes from other glial cells. It is closely related to its non-epithelial family members, vimentin, desm...

重组蛋白

Vimentin Protein, Human, Recombinant (His)

Cat.No: TMPY-04329

Species: Human

Expression System: Baculovirus Insect Cells

Vimentin Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02971

Species: Mouse

Expression System: HEK293 Cells

Vimentin Protein, Mouse, Recombinant (E. coli, His & Myc)

Cat.No: TMPH-02970

Species: Mouse

Expression System: E. coli

CEACAM5 Protein, Cynomolgus, Recombinant (aa 35-685, His)

Cat.No: TMPK-01299

Species: Cynomolgus

Expression System: HEK293 Cells

Nestin/NES Protein, Human, Recombinant (His)

Cat.No: TMPH-01752

Species: Human

Expression System: P. pastoris (Yeast)

GFAP Protein, Human, Recombinant (His)

Cat.No: TMPJ-00846

Species: Human

Expression System: E. coli

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