sphingomyelin

Sphingomyelin is a natural sphingolipid that existed in animal cell membranes. It implicates the regulation of transmembrane signaling.

Choline hydroxide 是一种普遍存在的水溶性营养素，通常与 B 族维生素有关。

C16 Sphingomyelin (d18:1 16:0) (N-Palmitoyl-D-sphingomyelin) 是磷脂双层膜的磷脂类化合物，可用于研究生物膜的活性。

C20 Sphingomyelin is a naturally occurring sphingolipid. Levels of C20 sphingomyelin are upregulated in the hippocampus of rats with diabetes induced by streptozotocin and in human plasma where it is positively correlated with insulin resistance in obese humans. C20 sphingomyelin is also upregulated in the liver of a mouse model of Niemann-Pick type C1 disease, a neurodegenerative cholesterol-sphingolipid lysosomal storage disorder. The plasma concentration of C20 sphingomyelin is decreased in men with prostate cancer.

13C C16 Sphingomyelin is an isotopically enriched form of C16 sphingomyelin with carbon-13 occurring on the fatty acid portion. It is intended for use as an internal standard for the quantification of C16 sphingomyelin by GC- or LC-MS. C16 Sphingomyelin is a form of sphingomyelin containing palmitate (16:0) at the variable acylation position. It is the most common form of sphingomyelin found in eggs and is less abundant in the brain and in milk. C16 Sphingomyelin interacts with cholesterol in ordered lipid domains (lipid rafts). Sphingomyelinases remove phosphorylcholine from C16 sphingomyelin to produce C16 ceramide. While ceramides commonly induce apoptosis, ceramides with different fatty acid chain lengths might direct distinct functions and, in some cases, reduce apoptosis.

C17 Sphingomyelin is a synthetic derivative of sphingomyelin that has been used as an internal standard for the quantification of sphingomyelin.

Sphingomyelinphosphodiesterase 是一种水解酶，参与鞘磷脂代谢过程。Sphingomyelinphosphodiesterase 水解鞘磷脂，使其向磷酸胆碱和神经酰胺转化。Sphingomyelinphosphodiesterase 还在细胞分化、各种免疫和炎症反应以及细胞内胆固醇运输和代谢中发挥重要作用。

C26:1 Sphingomyelin (d18:1 26:1(17Z)) 是一种脂质分子，可用于生命科学相关研究，其 CAS 号为 1448012-56-3。

C18 Sphingomyelin (d18:1 18:0) 是一种脂质分子，可用于生命科学相关研究，其 CAS 号为 54336-69-5。

C2 Sphingomyelin (d18:1 2:0) 是一种脂质分子，可用于生命科学相关研究，其 CAS 号为 74713-54-5。

Sphingomyelin (d18:1,C14:0) 为哺乳动物细胞中的一种重要鞘脂,有助于提高细胞膜的分子结构有序性.

Sphingomyelin (d18:1 12:0)为一种具调节细胞信号传导功能的极性脂质，它在细胞膜中扮演着至关重要的角色，不仅影响膜的流动性和稳定性，还参与脂质代谢并促进神经细胞生长。此外，Sphingomyelin (d18:1 12:0)在神经系统的功能发育中也具有不可或缺的作用。

C22 Sphingomyelin is a naturally occurring form of sphingomyelin . Plasma levels of C22 sphingomyelin positively correlate with hepatic steatosis severity in patients with chronic hepatitis C virus (HCV). C22 Sphingomyelin levels are decreased in T-47D mammary epithelial cells and increased in MDA-MB-231 breast cancer cells relative to C16 sphingomyelin .

C26 Sphingomyelin (d18:1 26:0) 是一种鞘磷脂，可用于研究神经系统疾病。

Sphingomyelin (chicken egg) (SMs (chicken egg)) 是一种来自于鸡蛋的鞘脂，是质膜的主要成分。Sphingomyelin (chicken egg) 在机体与信号传导有关。

Malabaricone C 是天然的鞘磷脂合成酶抑制剂，对 SMS 1 和 SMS 2 的IC50分别为 3 和 1.5 μM。

Lysosphingomyelin is an endogenous bioactive sphingolipid and a constituent of lipoproteins.1,2It is produced by the removal of the acyl group from sphingomyelin by a deacylase and acts as a precursor in the biosynthesis of sphingosine-1-phosphate . D-erythroLysosphingomyelin is an agonist of the S1P receptors S1P1, S1P2, and S1P3(EC50s = 167.7, 368.1, and 482.6 nM, respectively, for the human receptors).3It is also an agonist of the orphan receptor ovarian cancer G protein-coupled receptor 1 (ORG1) that induces calcium accumulation in cells overexpressing OGR1 (EC50= ~35 nM).4Levels of D-erythrolysosphingomyelin are increased in skin isolated from patients with atopic dermatitis, as well as postmortem brain from patients with Niemann-Pick disease type A, but not type B.2,5L-threolysosphingomyelin is also an S1P1-3agonist (EC50s = 19.3, 131.8, and 313.3 nM, respectively).3This product is a mixture of D-erythroand L-threolysosphingomyelin. [Matreya, LLC. Catalog No. 1321] 1.Ito, M., Kurita, T., and Kita, K.A novel enzyme that cleaves the N-acyl linkage of ceramides in various glycosphingolipids as well as sphingomyelin to produce their lyso formsJ. Biol. Chem.270(41)24370-24374(1995) 2.Nixon, G.F., Mathieson, F.A., and Hunter, I.The multi-functional role of sphingosylphosphorylcholineProg. Lipid Res.47(1)62-75(2008) 3.Im, D.-S., Clemens, J., Macdonald, T.L., et al.Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): Structure-activity relationship of sphingosine1-phosphate receptorsBiochemistry40(46)14053-14060(2001) 4.Meyer zu Heringdorf, D., Himmel, H.M., and Jakobs, K.H.Sphingosylphosphorylcholine-biological functions and mechanisms of actionBiochim. Biophys. Acta1582(1-3)178-189(2002) 5.Rodriguez-Lafrasse, C., and Vanier, M.T.Sphingosylphosphorylcholine in Niemann-Pick disease brain: Accumulation in type A but not in type BNeurochem. Res.24(2)199-205(1999)

Sphingomyelins (SMs) are bioactive sphingolipids found in mammalian cell membranes.1SMs make up 2-15% of the total organ phospholipid population but are found at higher concentrations in the brain and myelin sheaths surrounding peripheral nerves. They interact with cholesterol to control its distribution within cellular membranes and maintain cholesterol homeostasis in cells. SMs undergo hydrolysis by sphingomyelinase to form ceramides, which are sphingolipid mediators of intracellular signaling.2This product is a mixture of SMs, with variable fatty acyl chain lengths, isolated from buttermilk. [Matreya, LLC. Catalog No. 1329] 1.Slotte, J.P., and Ramstedt, B.The functional role of sphingomyelin in cell membranesEur. J. Lipid Sci. Technol.109(10)977-981(2007) 2.Shayman, J.A.SphingolipidsKidney Int.58(1)11-26(2000)

Sphingomyelins are complex membrane lipids composed of phosphorylcholine, sphingosine, and an acylated group, such as a fatty acid. Lysosphingomyelin is a naturally-occurring lipid which is produced by the removal of the acylated group of sphingomyelin by a deacylase. Lysosphingomyelin may, in turn, serve as a substrate for autotaxin, which removes choline to produce sphingosine-1-phosphate. The receptors and signaling pathways that are activated by lyso-sphingosine are diverse and vary between cell types. Lysosphingomyelin occurs naturally in plasma, is a constituent of lipoproteins, and is increased in some diseases, including dermatitis and Niemann-Pick disease.

N-Stearoylsphingomyelin (N-Stearoyl-D-sphingomyelin) 为抑制磷脂酶 Cδ1 (PLCδ1) 的鞘磷脂类化合物。

L-threo Lysosphingomyelin (d18:1) (L-threo-Sphingosylphosphorylcholine) is a naturally occurring bioactive sphingolipid. It acts as a potent agonist for S1P receptors, with EC50 values of 19.3, 131.8, and 313.3 nM for hS1P1, hS1P3, and hS1P2, respectively.

SMS2-IN-1 是一种有效且具有高选择性的鞘磷脂合成酶 2 (SMS2) 抑制剂， IC50 为 6.5 nM，Kd 为 37 nM。SMS2-IN-1 对 SMS2 的选择性比 SMS1 (IC50 为 1000 nM) 多 150 倍。

SAR-114137 是一种组织蛋白酶鞘氨醇激酶抑制剂，可用于研究软动脉炎和周围神经性疼痛。

Citicoline sodium (CDP-choline) 是一种合成细胞膜组分磷脂酰胆碱的中间体，有神经保护作用。