sah

SAH (S-Adenosylhomocysteine) 属于氨基酸衍生物，是腺苷和半胱氨酸合成的中间体。SAH 是一种 METTL3-METTL14 异二聚体复合物的抑制剂 (IC50=0.9 µM)。SAH 是多种代谢途径中的调节剂。

HLY78 (4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine) 是 Wnt β-catenin 信号通路的激活剂，通过靶向通道中 Axin 的 DIX 域，增强 Axin-LRP6 交联，诱导 Wnt 信号转导。

FIDAS-5 是甲硫氨酸腺苷转移酶 2A （MAT2A）抑制剂，其IC50值为2.1 μM，具有口服活性。它能够与 S-腺苷甲硫氨酸有效竞争 MAT2A 结合，并具有抗癌作用。[1]

FIDAS-3 是一种强效Wnt 抑制剂，也是一种二苯乙烯衍生物，对甲硫氨酸腺苷转移酶 2A (MAT2A) 的IC50为 4.9 μM。它能够与 S-腺苷甲硫氨酸有效竞争MAT2A 结合，并具有抗癌作用。

SIBA (5'-Deoxy-5'-isobutylthioadenosine) 是 SAH 的合成类似物，可作为 S-腺苷甲硫氨酸介导的甲基转移的抑制剂。它干扰多种酶活性，可逆地阻断单纯疱疹病毒 1 型病毒的繁殖。

ML351 是一种高度特异的15-LOX-1抑制剂，其 IC50=200 nM。它对 T1D 非肥胖糖尿病小鼠模型的血糖异常和β细胞氧化应激有抑制作用。它对相关同工酶 (5-LOX、血小板 12-LOX、15-LOX-2、绵羊 COX-1 和人 COX-2) 表现出良好的选择性(>250倍)。

SAH-SOS1A TFA 是一种基于肽的SOS1 KRAS 蛋白相互作用抑制剂。SAH-SOS1A TFA 以纳摩尔亲和力 (EC50=106-175 nM) 与野生型和突变型 KRAS (G12D, G12V, G12C, G12S, Q61H) 结合，直接和独立地阻断核苷酸结合。SAH-SOS1A TFA 损害 KRAS 驱动的癌细胞活力，并通过阻断 KRAS 下游 ERK-MAPK 磷酸化信号级联的机制发挥作用。

EZH2/EPP interaction inhibitor (Kd = 320 nM). Suppresses EZH2 expression and H3K27 trimethylation by PCR2 complex. Arrests proliferation and induces monocyte to macrophage differentiation of MLL-AF9 leukemia cell line.

KRas son of sevenless 1 (SOS1) interaction inhibitor. Binds within nucleotide binding pocket of KRas (Kd values are 106 - 176 nM for wild type KRas and various KRas mutants). Inhibits nucleotide binding to KRas in a concentration dependent manner. Display

CN-SAH is a potent and selective inhibitor of DOT1L.

Docosahexaenoic Acid 属于天然产物，是一种 ω-3 脂肪酸，在脑和视网膜中较为丰富。Docosahexaenoic Acid 对大脑的生长和功能发育至关重要。

1-Docosahexaenoyl-sn-glycero-3-phosphocholine, an ester product, is a phospholipid containing DHA (docosahexaenoic acid), often used in biomedical research as an important source of omega-3 fatty acids.

Palmitoyldocosahexaenoyl phosphatidylcholine 是一种多不饱和脂肪酸，可模拟特殊细胞膜结构域脂质。

Docosahexaenoic Acid methyl ester (all cis-DHA methyl ester) 是甲基化的二十二碳六烯酸类似物，能够插入膜磷脂中而不被氧化或水解。

SAHA chloroalkane T1 is a novel compound formed by combining Vorinostat (SAHA) with a chloroalkane capture tag, referred to as T1. This innovative approach involves tethering the SAHA molecule with the T1 tag, resulting in the formation of SAHA chloroalkane T1.

1-1(Z)-Octadecenyl-2-docosahexaenoyl-sn-glycero-3-PE (18:0p 22:6-PE) 为一种通过质谱成像技术在大鼠脑组织中确认的独特结构脂质，此方法可准确识别其不同脂肪酸链的异构体及其分布。

1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-phosphoethanolamine（18:0-22:6 PE）是一种用于构建脂质体的关键脂质成分。脂质体以其同心磷脂双层膜结构主要用于抗癌和抗感染的药物递送系统中。该化合物能够在其水性内部空间包裹高极性水溶性药物，同时将亲脂药物整合入脂质双层。它尤其适用于递送反义寡核苷酸，有效解决细胞内吸收不足和药物体内迅速丢失的问题。

1,3-Dilinoleoyl-2-docosahexaenoyl glycerol 是一种三酰甘油，其在 sn-1 和 sn-3 位连接Linoleic acid，在 sn-2 位连接Docosahexaenoic acid。

1,3-Didocosahexaenoyl glycerol (DG(22:6 0:0 22:6)) 是一种 ω-3 多不饱和脂肪酸，与 Poly-l-glutamic acid (PGA) 结合后，在大鼠心肌缺血 再灌注 (I R) 损伤模型中显示出心脏保护效果。

4-Iodo-SAHA (1k) 是一种具有口服活性的I 类和II 类histone deacetylase (HDAC)抑制剂，对 Skbr3、 HT29、 U937、 JA16 和 HL60细胞的EC50值分别为1.1、0.95、0.12、0.24、0.85和1.3 μM。4-Iodo-SAHA (1k) 可用于癌症的研究。

Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. SAHA-BPyne is a SAHA derivative with a benzophenone crosslinker and an alkyne tag intended to be used for profiling HDAC activities in proteomes and live cells. Such terminal alkyne groups can be used in linking reactions, known as click chemistry, characterized by high dependability and specificity of azide-alkyne bioconjugation reactions. SAHA-BPyne labels HDAC complex proteins both in proteomes at 100 nM and in live cells at 500 nM and demonstrates an IC50 value of ~3 μM for inhibition of HDAC activity in HeLa cell nuclear lysates in an HDAC activity assay.

SAHO is a sulfoxide form of the methyl donor S-(5'-adenosyl)-L-methionine chloride and a substrate for radical SAM enzymes.1It is reductively cleaved to S-adenosylhomocysteine , 5'-deoxyadenosine , and 5'-thioadenosine sulfenic acid by the radical SAM enzymes NosL or NosN. 1.Mandalapu, D., Ji, X., and Zhang, Q.Reductive cleavage of sulfoxide and sulfone by two radical S-adenosyl-L-methionine enzymesBiochemistry58(1)36-39(2019)

SAHO2is a sulfone form of the methyl donor S-(5'-adenosyl)-L-methionine chloride and is a substrate for radical SAM enzymes.1It is reductively cleaved to 5'-deoxyadenosine and 5'-thioadenosine sulfinic acid by the radical SAM enzymes NosL or NosN. 1.Mandalapu, D., Ji, X., and Zhang, Q.Reductive cleavage of sulfoxide and sulfone by two radical S-adenosyl-L-methionine enzymesBiochemistry58(1)36-39(2019)

Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. [1] coumarin-Suberoylanilide hydroxamic acid (c-SAHA) is a SAHA derivative where the anilino cap group is replaced by 7-amino-4-methylcoumarin to produce a fluorescent probe that competitively binds HDAC. [2] The fluorescence excitation and emission maxima of free c-SAHA is 325 and 400 nm