s186

S186 is a kind of sodium salts of calcium-acetylpropylamine phosphonate(APA); and is a new agent of strontium-specific chelating.

Sodium hexacyclonate is a biochemical.

OTS186935 FA 是一种蛋白甲基转移酶 SUV39H2 抑制剂。OTS186935 FA在 MDA-MB-231 乳腺癌细胞和 A549 肺癌细胞中抑制肿瘤的生长。

OTS186935 is a inhibitor of protein methyltransferase SUV39H2(IC50 of 6.49 nM).

OTS186935 trihydrochloride is a protein methyltransferase inhibitor of SUV39H2(IC50 of 6.49 nM).

S18616 Hydrochloride 是一种选择性且高效的 alpha2-肾上腺素受体激动剂。

OTS186935 hydrochloride 是蛋白甲基转移酶 SUV39H2 的有效抑制剂 (IC50: 6.49 nM)。OTS186935 hydrochloride 在小鼠异种移植模型中，能够明显抑制肿瘤生长，且没有明显毒性。OTS193320 hydrochloride 能够调节癌细胞中 γ-H2AX 的产生。

BMS 186318 is a human immunodeficiency virus (HIV) protease inhibitor designed to examine the possibility of developing resistance when two protease inhibitors are used together in recombination.

BMS-37 is a novel inhibitor of PD-1 PD-L1 immune checkpoint.

BMS-186511 is a Farnesyltransferase (FT) inhibitor with potential anticancer activity. BMS-186511 is a bisubstrate analogue inhibitor of FT, would inhibit the malignant growth properties of a cell line established from malignant schwannoma of an NF1 patient. Following treatment with BMS-186511 , ST88-14 cells became flat, nonrefractile, were contact-inhibited, and lost their ability to grow in soft agar. BMS-186511 was found to specifically inhibit FT, but not geranylgeranyltransferase I, a closely related enzyme. Thus, it is conceivable that FT inhibitors may ultimately become the first generation of drugs against the malignant phenotype in NF1 based on rational insights into the mechanism of action of neurofibromin.