regenerating

Costunolide (Costus lactone) 是一种天然的倍半萜内酯，具有抗氧化、抗炎、抗过敏、骨重塑、神经保护、促进毛发生长、抗癌和抗糖尿病的特性，可诱导乳腺癌细胞周期阻滞和凋亡。

Pentamidine dihydrochloride (MP-601205 dihydrochloride) 是一种抗微生物剂，会干扰 DNA 的生物合成。它是选择性蛋白酪氨酸磷酸酶和再生肝磷酸酶抑制剂。它可用于冈比亚锥虫病，抗锑利什曼病和卡氏肺孢子虫肺炎的研究，有抗肿瘤活性，抗菌活性。

Thienopyridone is a potent and selective inhibitor of phosphatase of regenerating liver (PRL) phosphatase(IC50s of 173 nM, 277 nM and 128 nM for PRL-1, PRL-2, and PRL-3, respectively), and induces p130Cas cleavage and apoptosis and has anticancer effects.

Y-33075（Y-39983 free base）是一种ROCK抑制剂，能够降低眼压，增加视神经头（ONH）血流，增加体内具有再生轴突的RGCs（视网膜神经节细胞）的数量。

ESI1 是一种作用于表观遗传的小分子沉默抑制剂。该化合物能促使关键的脂质代谢调控因子 SREBP1 2 形成核凝聚体，并聚焦转录共激活因子，推动脂质与胆固醇的生物合成。在脱髓鞘动物模型中，ESI1 有助于髓鞘的重建，并能在中枢神经系统 (CNS) 轴突上实现从头到尾的髓鞘生成，从而逆转与年龄相关的认知能力衰退。

PRL-3 Inhibitor I (BR-1) 是 PRL-3 抑制剂，IC50=0.9 μM。它在细胞检测中显示降低侵袭性。

17-phenyl trinor PGE2 ethyl amide is derived from 17-phenyl trinor PGE2, a synthetic analog of PGE2 that acts as an agonist of EP1 and EP3 receptors in mice (Ki = 14 and 3.7 nM, respectively) and EP1, EP3, and EP4 in rats (Ki = 25, 4.3, and 54 nM, respectively). 17-phenyl trinor PGE2 causes contraction of guinea pig ileum at a concentration of 11 μM and is 4.4 times more potent than PGE2 as an antifertility agent in hamsters. Modification of the C-1 carboxyl group to an ethyl amide serves to increase lipid solubility, thereby improving uptake into tissues and further lowering the effective concentration. Ethyl amide groups are then removed by amidases, regenerating the active free acid.

PRL-IN-1 (compound 43) 作为一种有效的肝脏再生磷酸酶 (PRL) 抑制剂，能够直接与 PRL1 三聚体界面结合，从而阻止 PRL1 的三聚化过程。此外，PRL-IN-1 还展示了显著的抗癌活性。

Ursolic aldehyde can inhibit phosphatase of regenerating liver-3, with the IC(50) value of 50 + - 0.3 mu M.