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15

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1268	CEF19, Epstein-Barr Virus latent NA-3A (458-466) CEF19,Epstein-Barr Virus latent NA-3A 458-466
	CEF19, Epstein-Barr Virus latent NA-3A (458-466) is a single peptide epitope, YPLHEQHGM, representing residues 458-466 of the type 1 Epstein-Barr Virus (EBV) nuclear antigen 3A protein (B95.8 strain).
T0850	Primaquine diphosphate Primaquine phosphate,磷酸伯氨喹,Primaquine bisphosphate,磷酸伯安喹	Antibiotic; Parasite	Microbiology/Virology
	Primaquine diphosphate 是一种合成的 8-氨基喹啉衍生物，具有抗疟特性。它是一种能破坏间日疟原虫和卵形疟原虫肝脏晚期和潜在组织形态的化合物。
T32668	Leucomalachite green NSC36379,NSC 36379,隐色孔雀绿,NSC-36379	Others	Others
	Leucomalachite green (NSC-36379) 是孔雀石绿的主要代谢物，是潜在的致癌物、致畸物和诱变剂。它是一种三苯甲烷燃料，可用于检测血液。
T10603	BRD-6929	HIV Protease; HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
	BRD-6929 是一种选择性的脑渗透性的HDAC1和HDAC2抑制剂，IC50值为 1 和 8 nM。它对 HDAC1 和 HDAC2 有高亲和力，Ki 值为 0.2 和 1.5 nM。它可研究情绪相关行为。
T24132	HDAC3-IN-T326 HDAC3 inhibitor-T326,T326,HDAC3 IN T326,HDAC3 inhibitor T326,HDAC3INT326
	HDAC3-IN-T326 is a potent and selective HDAC3 inhibitor that acts by increasing NF-κB acetylation and activating HIV gene expression in latent HIV-infected cells.
T27988	MDG486 BAF IN A01,A01,MDG-486,MDG 486,BAF-IN-A01
	MDG486, an inhibitor of BAF, works by activating latent HIV-1.
T27611	Ingenol 3-Hexanoate
	Ingenol 3-Hexanoate is a novel potent reactivator of latent HIV-1.
T40191	17-GMB-APA-GA
	17-GMB-APA-GA, a potent HSP90 inhibitor, is an ADC cytotoxin commonly employed for studying latent T. gondii infection.
T28818	SMAPP1
	SMAPP1 is an activator of protein phosphatase 1 (PP1). SMAPP1 induces PP1 activity in vitro and activates latent HIV-1 provirus in cultured and primary T cells.
T61310	HIV-1 inhibitor-37
	HIV-1 inhibitor-37 (Compound 83) is a highly powerful HIV-1 inhibitor. It exhibits significant potential for use as an innovative latent HIV-1 reactivating agent [1].
T77067	Livmoniplimab
	Livmoniplimab (ABBV-151; ARGX-115) 是一种有效的人源化抗 LRRC32 (GARP)/TGFβ1 单克隆抗体。Livmoniplimab 阻断 LRRC32 介导的潜在 TGFβ1 激活。Livmoniplimab 具有癌症研究的潜力。
T81931	Linavonkibart
	Linavonkibart (SRK 181) 是高亲和性全人源化抗体, 能选择性结合TGFβ1并阻断其活化。该化合物在癌症治疗中扮演关键角色。
T68502	Dibrospidium Free Base
	Dibrospidium Free Base is a dispirotripiperazine derivative and alkylating agent with potential antineoplastic and anti-inflammatory activities. The duration of DNA synthesis inhibition in tumor cells was found to correlate with spirobromine antitumor activity. Spirobromin is superior to prospidin by the power of the anti-inflammatory effect. Spyrobromin can diminish the latent period of the development of tumours in the experimental rats at intraperitoneal administration. At intragastric admini...
T69009	Gnidimacrin
	Gnidimacrin activated HIV-1 replication and killed persistently-infected cells at picomolar concentrations. In addition to its potential to purge HIV-1 from latently infected cells, gnidimacrin potently inhibited a panel of HIV-1 R5 virus infection of peripheral blood mononuclear cells (PBMCs) at an average concentration lower than 10 pM. These results suggest that gnidimacrin could activate latent HIV-1, specifically kill HIV-1 persistently infected cells, and inhibit R5 viruses at picomolar c...
T73986	ONX-0914 TFA
	ONX-0914 (PR-957) TFA 为针对免疫蛋白酶体中的LMP7（低分子量多肽-7）的选择性抑制剂，LMP7为类糜蛋白酶亚单位。该化合物通过抑制细胞因子产生，减缓实验性关节炎进展，并已证实为分枝杆菌蛋白酶体的非竞争性不可逆抑制剂（Ki=5.2 μM）。此外，ONX-0914 TFA 能通过HSF-1介导的p-TEFb活化，激活潜伏的HIV-1。

化合物

CEF19, Epstein-Barr Virus latent NA-3A (458-466)

Cat.No: TP1268

Synonym: CEF19,Epstein-Barr Virus latent NA-3A 458-466

Primaquine diphosphate

Cat.No: T0850

Synonym: Primaquine phosphate,磷酸伯氨喹,Primaquine bisphosphate,磷酸伯安喹

Target: Antibiotic, Parasite

Leucomalachite green

Cat.No: T32668

Synonym: NSC36379,NSC 36379,隐色孔雀绿,NSC-36379

Target: Others

Cat.No: T10603

Target: HIV Protease, HDAC

Cat.No: T24132

Synonym: HDAC3 inhibitor-T326,T326,HDAC3 IN T326,HDAC3 inhibitor T326,HDAC3INT326

Cat.No: T27988

Synonym: BAF IN A01,A01,MDG-486,MDG 486,BAF-IN-A01

Ingenol 3-Hexanoate

Cat.No: T27611

Cat.No: T40191

Cat.No: T28818

HIV-1 inhibitor-37

Cat.No: T61310

Cat.No: T77067

Cat.No: T81931

Dibrospidium Free Base

Cat.No: T68502

Cat.No: T69009

Cat.No: T73986

Cat. No.	Product Name	Target	Signaling Pathways
T5S2017	Ingenol (-)-Ingenol,巨大戟二萜醇,巨大戟醇	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	Ingenol ((-)-Ingenol) 是一种PKC 激活剂，Ki 值为 30 μM，具有抗肿瘤活性。从 Ingenol 酯中配制新的衍生物可能是开发新的先导化合物以重新激活潜伏 HIV 的创新方法。Ingenol mebutate 是治疗光化性角化病的有效方法。
T3926	Echinatin 刺甘草查尔酮,Retrochalcone	Free radical scavengers	oxidation-reduction
	Echinatin (Retrochalcone) 是分离自中草药甘草中，具有保肝和抗炎活性。在大鼠中，它可以被快速吸收和消除，并广泛分布，绝对生物利用度约为 6.81％。
TN3914	Echinatine	ATPase; IL Receptor; TNF	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel
	Echinatin exerts a protective effect against ischemia/reperfusion (I/R)-induced myocardial injury on hearts, this effect may be attributed to the antioxidant and anti-inflammatory activities of this compound. Echinatin can inhibit DNP-ATPase activity whil

天然产物

Cat.No: T5S2017

Synonym: (-)-Ingenol,巨大戟二萜醇,巨大戟醇

Target: PKC

Cat.No: T3926

Synonym: 刺甘草查尔酮,Retrochalcone

Target: Free radical scavengers

Cat.No: TN3914

Target: ATPase, IL Receptor, TNF

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