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34

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T0957	Isradipine PN 200-110,伊拉地平	Calcium Channel; Autophagy	Autophagy; Membrane transporter/Ion channel; Metabolism
	Isradipine (PN 200-110) 是一种二氢吡啶类钙通道阻滞剂，具有抗高血压和血管扩张活性。它是一种具有口服活性的 L 型钙通道阻滞剂，也是一种潜在可行的帕金森病神经保护剂。
TP2373L	Biotinoyl tripeptide-1 Acetate Biotinoyl tripeptide-1 Acetate(299157-54-3 Free base)	Others	Others
	Biotinoyl tripeptide-1 Acetate 可通过促进头皮微循环产生毛囊，减少毛囊萎缩和衰老。
TNU0429	N6-(2-Hydroxyethyl)adenosine	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	N6-(2-Hydroxyethyl)adenosine 是一种 Ca2+拮抗剂和抗炎剂，与脑和冠状动脉循环的控制有关，被认为具有镇静活性。
T10502	Benzcyclane 苄环庚烷,Benzcyclan,Bencyclane	Others; Platelet aggregation	Others
	Benzcyclane (Benzcyclan) 是一种血小板聚集抑制剂，也是一种血管扩张剂，可用于多种外周循环障碍。
T15006	Dirlotapide CP742033,Slentrol	Others; CETP	Metabolism; Others
	Dirlotapide (CP742033) 是一种肠道选择性微粒体甘油三酯转移蛋白(MTP)抑制剂。它可以减轻糖尿病狗的体重。Dirlotapide 以剂量依赖性方式减少食物摄入量，可能是通过增加肽YY 释放到循环中。
T1776L	Plerixafor octahydrochloride 盐酸普乐沙福,JM3100 octahydrochloride,Plerixafor 8HCl (AMD3100 8HCl),Plerixafor 8HCl,SID791 octahydrochloride,AMD 3100 octahydrochloride,JM 3100 8HCl	Virus Protease; HIV Protease; CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Plerixafor octahydrochloride (JM3100 octahydrochloride) 是一种选择性的CXCR4拮抗剂，IC50为 44 nM。Plerixafor 是一种具有造血干细胞动员活性的双环霉素。
T21327	Uridine triacetate RG 2133 triacetate,PN-401,Tri-O-acetyluridine,PN401,RG 2133,RG-2133,PN 401,RG2133,RG2133 triacetate	Others	Others
	Uridine triacetate (RG 2133 triacetate) 是一种具有口服活性的 Uridine 前药。Uridine triacetate 能在肠道内迅速被吸收，在循环中迅速脱乙酰，生成游离尿苷。Uridine triacetate 可用于研究 5-氟尿嘧啶 (5-FU) 和卡培他滨的毒性，或早发性心脏或中枢神经系统 (CNS) 毒性。
T9857	Vasopressin antidiuretic hormone (ADH),argipressin,arginine vasopressin (AVP)	Endogenous Metabolite	Metabolism
	Vasopressin (argipressin) 是一种由下丘脑神经元合成的环状九肽，是肽原激素合成中的一种激素。Vasopressin 参与下丘脑-垂体-肾上腺轴调节过程，增加无溶质水从肾小管的滤液中重新吸收回循环中的量，收缩小动脉提高压强，增强促肾上腺皮质激素释放因子的刺激作用调节垂体促肾上腺皮质激素分泌。Vasopressin 在神经传导过程中可作为神经递质，与特定的 G 蛋白偶联受体结合发挥作用。
T13588	Ipramidil C80-1324,异丙地尔	Others	Others
	Ipramidil (C80-1324) reveals marked dilator activity in the coronary circulation of isolated working hearts.
T30602	Bts 39542 Bts-39542,Bts39542
	Bts 39542 is a diuretic that plays a major role in the Henle circulation and increases renal blood flow without affecting glomerular filtration rate.
TP2373	Biotinoyl tripeptide-1 Biotin GHK,BiotinGHK,Biotin-GHK
	Biotinoyl tripeptide-1 can produce hair follicles by promoting scalp micro-circulation and reduce follicle atrophy and aging.
T30317	Bencyclane Fumarate Halidor,Diacyclan,Angiodel,Angiociclan,Hemoflux
	Bencyclane Fumarate (Halidor) is a vasodilator that is effective against a variety of peripheral circulation disorders.
T74311	DPPE-mPEG
	DPPE-mPEG 是一种 PEG- 修饰的脂类。DPPE-mPEG 可以减少蛋白质的非特异性吸附，延长体内循环时间。
T36124	3β-hydroxy-5-Cholestenoic Acid
	3β-hydroxy-5-Cholestenoic Acid 是在人体循环中浓度很高（40-80 ng/ml）的是胆固醇的代谢产物之一。
T26577	AGN-201904Z AGN-201904-Z,AGN-201904
	AGN-201904Z is a slowly absorbed, acid-stable pro-proton pump inhibitor (pro-PPI) rapidly converted to omeprazole in the systemic circulation giving a prolonged residence time. AGN 201904-Z produced a significantly greater, and nocturnal acid suppression
T38967	DSPE-PEG(2000)
	MPEG-2000-DSPE sodium is a phospholipid PEG conjugate with hydrophilicity and hydrophobicity. It is utilized in liposome synthesis to enhance the hydrophilicity of liposomes, thereby prolonging their circulation in the bloodstream. This compound is commonly employed for the investigation of anticancer and antimalarial agents.
T69072	Brovincamine
	Brovincamine also known as brovincamine fumarate (BV, Sabromin) was used in Japan mainly as an improver of cerebral circulation and metabolism, and also as an inhibitor of the aggregation of platelets through the cyclic AMP pathway in patients with normal tension glaucoma. Brovincamine exerts its action via calcium channels blockade. Brovincamine is also a vasodilator.
T36968	ARN-21934	Topoisomerase	DNA Damage/DNA Repair
	ARN-21934 是高选择性的人拓扑异构酶 II α 抑制剂，具有血脑屏障通透性。依托泊苷抑制 DNA 松弛的IC50为120 μM，ARN-21934 抑制 DNA 松弛的IC50为 2 μM。ARN-21934具有良好的体内药代动力学特性。
T63452	Benidipine
	Benidipine 是一种有效的、口服具有活力的钙通道拮抗剂。Benidipine 能够提高内皮细胞型一氧化氮合酶的活性，改善高血压大鼠冠状动脉循环。Benidipine 能够抗缺血/再灌注心肌细胞的凋亡。
T74187	DSPE-PEG Carboxylic acid sodium (MW 2000)
	DSPE-PEG Carboxylic acid sodium (MW 2000) 为聚乙二醇脂质类化合物，主要功能是形成胶束，用作纳米粒子药物传递系统。此外，该化合物能有效延长脂质体在血液中的循环时间。
T74245	DSPE-PEG
	DSPE-PEG为磷脂-聚合物偶联物，在药物递送应用中有重要用途。该材料能作为纳米载体的基础，用以增强血液循环时间、稳定性及封装效率。
T40744	Eperisone
	Eperisone is a centrally acting muscle relaxant and antispastic agent utilized in the treatment of conditions distinguished by muscle stiffness and pain. Its mechanism of action involves the relaxation of skeletal muscles and vascular smooth muscles, resulting in a range of beneficial effects including reduction of myotonia, enhancement of circulation, and suppression of the pain reflex. Additionally, Eperisone exhibits inhibitory properties on the pain reflex pathway and exerts a vasodilator ef...
T69127	Moxisylyte
	Moxisylyte, also known as thymoxamine, is a drug used in urology for the treatment of erectile dysfunction. It is an α1-adrenergic antagonist. Moxisylyte is also used for the short-term treatment of primary Reynaud's syndrome, a condition where the fingers and toes become discoloured in response to cold or emotional distress. Moxisylyte helps by improving blood circulation to the extremities. It is also used locally in the eye to reverse the mydriasis caused by phenylephrine and other sympathomi...
T36220	2,3-dinor Thromboxane B1 2,3-dinor Thromboxane B1
	Thromboxane B2 (TXB2) is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB2 and 2,3-dinor TXB2. In rats and rabbits, 2,3-dinor TXB1 has been identified as another urinary metabolite of TXB2. However in human urine, only trace amounts of 2,3-dinor TXB1 have been identified. In rats, 2,3-dinor TXB1 is excreted at a much higher rate than 2,3-dinor TXB2 (19.2 ± 4.9 ng/24 hr and 1.6 ± 0.3 ng/24 hr, respectively). Therefore, urinary 2,3-...
T73610	Lipoprotein lipase
	Lipoprotein lipase 是来自于脂肪组织、心肌和骨骼肌、胰岛和巨噬细胞的多功能酶。Lipoprotein lipase 促进正常脂蛋白代谢、组织特异性底物的输送和利用。Lipoprotein lipase 催化脂质在血液循环的限速步骤。
T74139	MPEG-2000-DSPE
	MPEG-2000-DSPE 是一种磷脂-聚乙二醇偶联物，具有亲水性和疏水性。MPEG-2000-DSPE 被用于脂质体的合成，增加脂质体表面的亲水性，从而延长脂质体在血液循环中的寿命，用于抗癌和抗疟活性分子的研究。
TP1756	Brain Natriuretic Peptide (1-32), rat Brain Natriuretic Peptide (BNP) (1-32), rat
	Brain Natriuretic Peptide (BNP) (1-32), rat is a 32 amino acid polypeptide secreted by the ventricles of the heart in response to excessive stretching of heart muscle cells (cardiomyocytes).Brain natriuretic peptide (type B natriuretic peptide) was origin
T32705	Levomefolate magnesium L-Methylfolate magnesium
	Levomefolate magnesium is the magnesium salt of the metabolite of folic acid (Vitamin B9) and it is a predominant active form of folate found in foods and in the blood circulation, accounting for 98% of folates in human plasma. It is transported across th
T17331	(2-pyridyldithio)-PEG4 acid	Others	Others
	(2-Pyridyldithio)-PEG4 acid is a four-unit cleavable polyethylene glycol (PEG) linker specifically designed for the synthesis of antibody-drug conjugates (ADCs)[1]. It serves as a crucial component in the conjugation of antibodies and drugs, enabling targeted drug delivery and enhanced therapeutic efficacy. This linker possesses a (2-pyridyldithio) group at one end, facilitating the attachment of the linker to the specific site on the antibody molecule. The PEG4 chain provides the necessary flex...
T38503	(2-pyridyldithio)-PEG1-hydrazine (2-pyridyldithio)-PEG1-hydrazine
	(2-Pyridyldithio)-PEG1-hydrazine is a one-unit cleavable polyethylene glycol (PEG) linker specifically designed for the synthesis of antibody-drug conjugates (ADCs). This linker offers the advantage of controlled release of the drug payload from the ADC construct. It is utilized in the conjugation process between the antibody and the cytotoxic drug, enabling the targeted delivery of the drug to cancer cells. The (2-pyridyldithio) group of this linker provides stability during circulation in the ...
T37355	CAY10703
	Dichloroacetate (DCA) is an inhibitor of all pyruvate dehydrogenase kinase (PDHK) isoforms, which are enzymes that phosphorylate and inhibit PDH in mitochondria. Inhibition of PDHK shifts cell metabolism from glycolysis to mitochondrial glucose oxidation, an effect that has relevance to cancer, type 2 diabetes, and other diseases. CAY10703 is a DCA trimer that is at least 10-fold more cytotoxic against leukemia cell lines than DCA. It is approximately 3-fold less cytotoxic than DCA against perip...
T83694	Gastric Inhibitory Peptide (1-42) (porcine) TFA GIP (1-42),Glucose-dependent Insulinotropic Polypeptide (1-42)
	胃抑制肽(GIP) (1-42)是一种内源性的42氨基酸肽类肠促素激素，能诱导胰岛素分泌。该激素在肠道神经内分泌K细胞和颌下腺中表达，并在餐后释放到循环中。GIP (1-42)抑制由组胺、五肽和胰岛素引起的胃酸和胃蛋白酶分泌，增加葡萄糖诱导的胰岛素释放，并在大鼠中刺激胃排空。
T38039	(E)-C-HDMAPP (ammonium salt)
	Synthetic and natural alkyl phosphates, also known as phosphoantigens, stimulate the proliferation of γδ-T lymphocytes. Isopentenyl pyrophosphate, and related derivatives including (E)-hydroxy-dimethyl-allyl pyrophosphate ((E)-HDMAPP), are particularly effective activators of γδ-T cells. (E)-C-HDMAPP is the pyrophosphonate form of (E)-HDMAPP. The pyrophosphonate moiety in (E)-C-HDMAPP is much less susceptible to chemical or enzymatic hydrolysis than its pyrophosphate counterpart. As a result, (E...
T35971	4-hydroxy Nonenal Mercapturic Acid
	Peroxidation of common ω-6 polyunsaturated fatty acids (PUFAs) such as linoleic acid, DGLA, and arachidonic acid can give rise to 4-HNE. 4-HNE is cleared rapidly from the plasma and undergoes enterohepatic circulation as a glutathione conjugate in the rat. About two thirds of an administered dose of 4-HNE is excreted within 48 hours in the urine, primarily in the form of mercapturic acid conjugates. The C-1 aldehyde of 4-HNE is reduced to an alcohol in about half of these metabolites. The remain...

化合物

Cat.No: T0957

Synonym: PN 200-110,伊拉地平

Target: Calcium Channel, Autophagy

Biotinoyl tripeptide-1 Acetate

Cat.No: TP2373L

Synonym: Biotinoyl tripeptide-1 Acetate(299157-54-3 Free base)

Target: Others

N6-(2-Hydroxyethyl)adenosine

Cat.No: TNU0429

Target: Calcium Channel

Cat.No: T10502

Synonym: 苄环庚烷,Benzcyclan,Bencyclane

Target: Others, Platelet aggregation

Cat.No: T15006

Synonym: CP742033,Slentrol

Target: Others, CETP

Plerixafor octahydrochloride

Cat.No: T1776L

Synonym: 盐酸普乐沙福,JM3100 octahydrochloride,Plerixafor 8HCl (AMD3100 8HCl),Plerixafor 8HCl,SID791 octahydrochloride,AMD 3100 octahydrochloride,JM 3100 8HCl

Target: Virus Protease, HIV Protease, CXCR

Uridine triacetate

Cat.No: T21327

Synonym: RG 2133 triacetate,PN-401,Tri-O-acetyluridine,PN401,RG 2133,RG-2133,PN 401,RG2133,RG2133 triacetate

Target: Others

Cat.No: T9857

Synonym: antidiuretic hormone (ADH),argipressin,arginine vasopressin (AVP)

Target: Endogenous Metabolite

Cat.No: T13588

Synonym: C80-1324,异丙地尔

Target: Others

Cat.No: T30602

Synonym: Bts-39542,Bts39542

Biotinoyl tripeptide-1

Cat.No: TP2373

Synonym: Biotin GHK,BiotinGHK,Biotin-GHK

Bencyclane Fumarate

Cat.No: T30317

Synonym: Halidor,Diacyclan,Angiodel,Angiociclan,Hemoflux

Cat.No: T74311

3β-hydroxy-5-Cholestenoic Acid

Cat.No: T36124

Cat.No: T26577

Synonym: AGN-201904-Z,AGN-201904

Cat.No: T38967

Cat.No: T69072

Cat.No: T36968

Target: Topoisomerase

Cat.No: T63452

DSPE-PEG Carboxylic acid sodium (MW 2000)

Cat.No: T74187

Cat.No: T74245

Cat.No: T40744

Cat.No: T69127

2,3-dinor Thromboxane B1

Cat.No: T36220

Synonym: 2,3-dinor Thromboxane B1

Lipoprotein lipase

Cat.No: T73610

Cat.No: T74139

Brain Natriuretic Peptide (1-32), rat

Cat.No: TP1756

Synonym: Brain Natriuretic Peptide (BNP) (1-32), rat

Levomefolate magnesium

Cat.No: T32705

Synonym: L-Methylfolate magnesium

(2-pyridyldithio)-PEG4 acid

Cat.No: T17331

Target: Others

(2-pyridyldithio)-PEG1-hydrazine

Cat.No: T38503

Synonym: (2-pyridyldithio)-PEG1-hydrazine

Cat.No: T37355

Gastric Inhibitory Peptide (1-42) (porcine) TFA

Cat.No: T83694

Synonym: GIP (1-42),Glucose-dependent Insulinotropic Polypeptide (1-42)

(E)-C-HDMAPP (ammonium salt)

Cat.No: T38039

4-hydroxy Nonenal Mercapturic Acid

Cat.No: T35971

Cat. No.	Product Name	Target	Signaling Pathways
T4S0592	Toddalolactone (+)-Toddalolactone,飞龙掌血内酯,毛两面针素	PAI-1	Metabolism
	Toddalolactone ((+)-Toddalolactone) 是一种Toddalia asiatica 的主要成分，能够抑制重组人纤溶酶原激活物抑制物-1(PAI-1)的活性， IC50=37.31 μM。
T4513	Vanillyl butyl ether 4-(Butoxymethyl)-2-methoxyphenol,香兰醇丁醚,Butyl vanillyl ether,香草醇丁醚	Others	Others
	Vanillyl butyl ether (Butyl vanillyl ether) 是香草特有风味和香气的来源。它是辣椒素类似物，对人体有感官刺激作用。它是环保且无毒的物质。它是烷氧基取代的苄基衍生物，主要用作调味剂。
TQ0240	6"-O-Apiosyl-5-O-Methylvisammioside	Others	Others
	6”-O-Apiosyl-5-O-Methylvisammioside 是中药颈复康的成分之一，颈复康具有活血通络，散风止痛的作用。
T4S1658	Benzoyloxypaeoniflorin 苯甲酰氧化芍药苷,Benzoyloxypeoniflorin,苯甲酰氧芍药苷	NF-κB; Tyrosinase	NF-κB; Proteases/Proteasome
	Benzoyloxypaeoniflorin (Benzoyloxypeoniflorin) 是一种酪氨酸酶抑制剂，分离于Paeonia suffruticosa 的根，对mushroom tyrosinase 的 IC50为 0.453 mM。它是一种NF-κB 抑制剂，它通过对血小板聚集和凝血的抑制作用，有助于改善血液循环。
TWA2417	Sodium taurocholate 牛黄胆酸钠(牛胆酸钠，牛胆酸钠盐，牛磺膽酸鈉，牛磺胆酸钠，牛磺胆酸钠盐，牛胆酸钠水合物，水合牛磺胆酸钠，牛胆酸钠(混合物)，牛黄胆酸钠(水合)，牛磺胆酸钠(标准品)),Taurocholate Sodium	Others	Others
	Sodium taurocholate (Taurocholate Sodium) hydrate 具有显著的生物学效应，例如通过上调 VEGF-A 的表达抑制肝动脉结扎所致的胆道损伤。对免疫系统具有一定的调节作用。
T5769	Stachydrine Methyl hygrate betaine,水苏碱,L-stachydrine,Proline betaine,N,N-Dimethyl-L-proline	NF-κB; Endogenous Metabolite	Metabolism; NF-κB
	Stachydrine (N,N-Dimethyl-L-proline) 是中国草本植物益母草的主要成分，具有促进血液循环和消除血瘀的功效。Stachydrine (N,N-Dimethyl-L-proline) 能够抑制NF-κB 信号通路。
TN1101	20(R)-Notoginsenoside R2 R-三七皂苷R2,20(R)-三七皂苷R	Others	Others
	20(R)-Notoginsenoside R2 is a natural product with Promote blood circulation and improve myocardial ischemia
T36295	Echistatin TFA
	Echistatin TFA, the smallest active RGD protein belonging to the family of disintegrins that are derived from snake venoms, is a potent inhibitor of platelet aggregation. Echistatin is a potent inhibitor of bone resorption in culture. Echistatin is a potent antagonist of αIIbβ3, αvβ3 and α5β1[1][2][3][4]. [1]. J Musial, et al. Inhibition of platelet adhesion to surfaces of extracorporeal circuits by disintegrins. RGD-containing peptides from viper venoms. Circulation. 1990 Jul;82(1):261-73.[2]. ...

天然产物

Cat.No: T4S0592

Synonym: (+)-Toddalolactone,飞龙掌血内酯,毛两面针素

Target: PAI-1

Vanillyl butyl ether

Cat.No: T4513

Synonym: 4-(Butoxymethyl)-2-methoxyphenol,香兰醇丁醚,Butyl vanillyl ether,香草醇丁醚

Target: Others

6"-O-Apiosyl-5-O-Methylvisammioside

Cat.No: TQ0240

Target: Others

Benzoyloxypaeoniflorin

Cat.No: T4S1658

Synonym: 苯甲酰氧化芍药苷,Benzoyloxypeoniflorin,苯甲酰氧芍药苷

Target: NF-κB, Tyrosinase

Sodium taurocholate

Cat.No: TWA2417

Synonym: 牛黄胆酸钠(牛胆酸钠，牛胆酸钠盐，牛磺膽酸鈉，牛磺胆酸钠，牛磺胆酸钠盐，牛胆酸钠水合物，水合牛磺胆酸钠，牛胆酸钠(混合物)，牛黄胆酸钠(水合)，牛磺胆酸钠(标准品)),Taurocholate Sodium

Target: Others

Cat.No: T5769

Synonym: Methyl hygrate betaine,水苏碱,L-stachydrine,Proline betaine,N,N-Dimethyl-L-proline

Target: NF-κB, Endogenous Metabolite

20(R)-Notoginsenoside R2

Cat.No: TN1101

Synonym: R-三七皂苷R2,20(R)-三七皂苷R

Target: Others

Cat.No: T36295

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