adrenocortical carcinoma

Mitotane (NCI-C04933) 是 DDD 的同分异构体和 DDT 的衍生物，可作用于肾上腺皮质癌，有抗癌活性。

Perthane is the diethyl derivative of common pesticide DDD. It may cause adrenocortical atrophy in humans,and also prevent the formation of spontaneous mammary carcinoma.

Tetrahydro-11-deoxy cortisol (THS) is the primary urinary metabolite of 11-deoxycortisol. Urinary excretion of THS is elevated in patients with 11β-hydroxylase deficiency, a condition resulting from mutations in the cytochrome P450 (CYP) isoform CYP11B1. Urinary levels of THS are also elevated in patients with adrenocortical carcinoma (ACC) and adrenocortical adenoma (ACA) but are higher in patients with ACC compared to ACA.

Efonidipine(NZ-105)盐酸盐是T 型和L 型钙离子通道双重阻断剂。

FHD-609 为含溴结构域蛋白BRD9的抑制剂及降解剂，针对ncBAF，适用于研究含BAF复合亚基突变的多种癌症。FHD-609与Telomelysin或INO5401联用，或对肾上腺皮质癌(ACC)的研究具有潜在作用。

Efonidipine hydrochloride monoethanolate (NZ-105 hydrochloride monoethanolate) 是 T 型和 L 型钙离子通道双重阻断剂。

CBP-1008 是一种与 MMAE 偶联的双配体多肽-药物共轭物 (PDC)，专注于靶向叶酸受体 (FRα) 和 TRPV6。它显示出对 FRα 的高亲和力和对 TRPV6 的低亲和力。CBP-1008 具有抗肿瘤活性，适用于晚期实体瘤的研究 (例如：结直肠癌、乳腺癌、非小细胞肺癌、卵巢癌、肾上腺皮质癌和滤泡树突状细胞肉瘤)。