α-mannosidase

Swainsonine (Tridolgosir) 是一种从黄芪中分离出来的一种生物碱，是一种强效和可逆的α-甘露糖苷酶抑制剂。Swainsonine 具有抗肿瘤活性，可诱导细胞凋亡和细胞周期停滞在 G2 M 期。

Lysosomal α-mannosidase (EC:3.2.1.24; MAN2B1; LAMAN) 是一种外切糖苷酶，能够水解甘露糖聚糖中的 α-甘露糖苷键。该酶对于 α-甘露糖苷贮积症的研究具有重要价值。

1-Deoxymannojirimycin hydrochloride 是一种选择性的 α1,2-甘露糖苷酶抑制剂，IC50值为 20 μM。它还抑制 HIV-1 毒株，抗病毒活性较差。

Plantagoside 是α-mannosidase 的非竞争性特异性抑制剂(IC50:5 μM)，分离自Plantago asiatica 种子中。

Australine is a pyrrolizidine alkaloid originally isolated fromC. australethat has enzyme inhibitory activities.1,2,3It is an inhibitor of glucoamylase (IC50= 5.8 μM) that also inhibits glucosidase I, sucrase, maltase, andA. nigerα-glucosidase (IC50s = 20, 28, 35, and 28 μM, respectively).2,3Australine is selective for these enzymes over glucosidase II, α- and β-mannosidase, and α- and β-galactosidase up to 500 μM, β-glucosidase, with only 5% inhibition at 66 μM, as well as isomaltase and trehalase (IC50= 97 and 160 μM, respectively). Australine (500 μg/ml) inhibits glycoprotein processing of viral glycoproteins in influenza virus-infected MDCK cells and induces the accumulation of glycoproteins.2 1.Molyneux, R.J., Benson, M., Wong, R.Y., et al.Australine, a novel pyrrolizidine alkaloid glucosidase inhibitor from Castanospermum australJ. Nat. Prod.51(6)1198-1206(1988) 2.Tropea, J.E., Molyneux, R.J., Kaushal, G.P., et al.Australine, a pyrrolizidine alkaloid that inhibits amyloglucosidase and glycoprotein processingBiochemistry28(5)2027-2034(1989) 3.Kato, A., Kano, E., Adachi, I., et al.Australine and related alkaloids: easy structural confirmation by 13C NMR spectral data and biological activitiesTetrahedron Asymmetry14(3)325-331(2003)

Panosialin wA 具备抑制 α,β-葡萄糖苷酶和甘露糖苷酶的功能，对流感病毒没有抑制效果，但显示出较弱的抗菌活性。