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PA3552-IN-1

Name: PA3552-IN-1
Brand: TargetMol
SKU: T67912
Price: 133 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.82%

货号 T67912Cas号 1008121-12-7

PA3552-IN-1 是一种抗生素佐剂，可以降低 PA3552 的表达，恢复 MDR 铜绿假单胞菌 DK2 菌株对 Polymyxin B 的敏感性。

为众多的药物研发团队赋能，

让新药发现更简单！

PA3552-IN-1

一键复制产品信息

很棒

纯度: 99.82%

货号 T67912Cas号 1008121-12-7

PA3552-IN-1 是一种抗生素佐剂，可以降低 PA3552 的表达，恢复 MDR 铜绿假单胞菌 DK2 菌株对 Polymyxin B 的敏感性。

规格	价格	库存
2 mg	¥ 133	现货
5 mg	¥ 218	现货
10 mg	¥ 375	现货
25 mg	¥ 777	现货
50 mg	¥ 1,230	现货
100 mg	¥ 1,870	现货
200 mg	¥ 2,630	现货
1 mL x 10 mM (in DMSO)	¥ 240	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.82%

颜色: 黄色

性状: Solid

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COA LCMS HNMR 产品操作手册

产品介绍

PA3552-IN-1 AI Summary

PA3552-IN-1 exhibits notable cytotoxic effects against human cancer cell lines HL60, KG1, Jurkat, and NALM6, with IC50 values of 280.0 nM, 490.0 nM, 530.0 nM, and 910.0 nM respectively. It also inhibits the binding between KIX-RLucN fused CBP and KID-RLucC fused CREB in human HEK293 cells with an IC50 of 1520.0 nM. Additionally, PA3552-IN-1 shows bioactivity against the Zika virus by inhibiting NS-1 and envelope protein with IC50 values of 1720.0 nM and 1340.0 nM, respectively. With a solubility of 3.3 µg/mL, the compound also demonstrates cytotoxicity against African Green monkey Vero E6 cells with a CC50 of 8150.0 nM and exhibits good permeability in a PAMPA assay with a permeability value of 30.7 x 10^-6 cm/s. Moreover, PA3552-IN-1 shows antimicrobial activity against strains such as Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli. It presents synergistic antibacterial effects when combined with polymyxin B and significantly reduces bacterial growth, enhancing survival rates in Caenorhabditis elegans infected with Pseudomonas aeruginosa. The compound also suppresses drug resistance development in Pseudomonas aeruginosa but exhibits acute toxicity in ICR mice at high doses..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	PA3552-IN-1 is an antibiotic adjuvant that can reduce the expression of PA3552 and restore the sensitivity of MDR Pseudomonas aeruginosa DK2 strain to Polymyxin B.

化学信息

分子量	310.67
分子式	C₁₃H₈ClFN₂O₄
CAS No.	1008121-12-7
Smiles	Oc1ccc(F)cc1C(=O)Nc1ccc(cc1Cl)[N+]([O-])=O
密度	1.595 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 12.5 mg/mL (40.24 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2188 mL	16.0942 mL	32.1885 mL	160.9425 mL
5 mM	0.6438 mL	3.2188 mL	6.4377 mL	32.1885 mL
10 mM	0.3219 mL	1.6094 mL	3.2188 mL	16.0942 mL
20 mM	0.1609 mL	0.8047 mL	1.6094 mL	8.0471 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。