Name: Ganitumab
Brand: TargetMol
SKU: T76810
Price: 2320 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 2,320

现货

5 mg

¥ 5,490

现货

10 mg

¥ 7,480

现货

25 mg

¥ 10,900

现货

50 mg

¥ 14,800

现货

生物活性

产品描述	Ganitumab (AMG 479) is a highly potent monoclonal antibody to type 1 insulin-like growth factor receptor (IGF1R). Ganitumab is recognized to bind to IGF1R at low concentration with KD value of 0.22 nM. Ganitumab can inhibit the interaction of IGF1R with IGF1 and IGF2 in mice. Ganitumab can be used to study cancer.
体外活性	Ganitumab (AMG 479; 0.032-500 nM; 10分钟; cT26细胞)结合到mIGF1R并抑制mIGF1R通过IGF1和IGF2介导的激活[1]。
体内活性	在无特定病原体且携带肿瘤的小鼠中，ganitumab（AMG 479；1 mg/剂量；腹腔注射）抑制了IGF1激活的小鼠肺中的mIGF1R[1]。在无胸腺的雌性裸鼠中，ganitumab（300 μg/剂量；腹腔注射）减少了外周血中的中性粒细胞[1]。在雄性无胸腺裸鼠中，ganitumab（300 μg/剂量；腹腔注射）导致了葡萄糖耐受性降低，并增加了血清中的mGH、mIGF1和mIGFBP3的水平[1]。
别名	加尼妥单抗, AMG 479
反应种属	Human
验证活性	Immobilized Human IGF1R/CD221 Protein (His) (TMPY-00834) at 1 μg/mL (100 μL/well) can bind Ganitumab. The EC50 is 22.38 ng/mL.
应用	ELISA FCM Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型	Human IgG1 kappa
推荐同型对照	Human IgG1 kappa, Isotype Control

偶联与修饰

偶联	Unconjugated

抗原信息

化学信息

分子量	145.70 kDa
CAS No.	905703-97-1

储存&溶解度

存储	Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

Ganitumab