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顶部生物活性储存和溶解信息计算器

Anti-Phospho-MLKL (Ser358) Antibody (4T982)

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产品编号 TMAB-01455

别名 p-MLKL (Ser358), p-MLKL (S358), Phospho-MLKL (S358), MLKL (p-Ser358), MLKL (p-S358)

Anti-Phospho-MLKL (Ser358) Antibody (4T982) 是一种 Mouse 抗体，靶向 Phospho-MLKL (Ser358)。Anti-Phospho-MLKL (Ser358) Antibody (4T982) 可用于 ICC/IF,IF,IHC-Fr,IHC-P。

Anti-Phospho-MLKL (Ser358) Antibody (4T982)

Anti-Phospho-MLKL (Ser358) Antibody (4T982)

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产品编号 TMAB-01455 别名 p-MLKL (Ser358), p-MLKL (S358), Phospho-MLKL (S358), MLKL (p-Ser358), MLKL (p-S358)

Anti-Phospho-MLKL (Ser358) Antibody (4T982) 是一种 Mouse 抗体，靶向 Phospho-MLKL (Ser358)。Anti-Phospho-MLKL (Ser358) Antibody (4T982) 可用于 ICC/IF,IF,IHC-Fr,IHC-P。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-MLKL (Ser358) Antibody (4T982) is a Mouse antibody targeting Phospho-MLKL (Ser358). Anti-Phospho-MLKL (Ser358) Antibody (4T982) can be used in ICC/IF,IF,IHC-Fr,IHC-P.
别名p-MLKL (Ser358), p-MLKL (S358), Phospho-MLKL (S358), MLKL (p-Ser358), MLKL (p-S358)
Ig Type
IgG
克隆号
4T982
交叉反应
(predicted:Human)
应用ICC/IFIFIHC-FrIHC-P
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:100-500; IF: 1:100-500
抗体种类
Monoclonal
宿主来源Mouse
亚细胞定位Cytoplasm. Cell membrane. Note=Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction.
构建方式Hybridoma Monoclonal Antibody
纯化方式Protein G purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1 mg/mL
研究背景This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015].
抗原信息
免疫原
KLH conjugated Synthesised monomethylpeptide: human MLKL around the phosphorylation site of Ser358
抗原种属
Human
基因名称
MLKL
基因ID
197259
蛋白名称
Mixed lineage kinase domain-like protein
Uniprot ID
Q8NB16
研究领域
Necroptosis,SARS Coronavirus,Other Kinases
功能
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.
化学信息
分子量Theoretical: 54 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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关键词

pMLKL (Ser358)pMLKL (S358)MLKL (pSer358)MLKL (pS358)MLKL (phospho-Ser358)MLKL (phospho-S358)MLKLMixed lineage kinase domain-like proteinhMLKL

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4个月前
5.0
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