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Anti-Phospho-MLKL (Ser358) Antibody (8V821)

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Anti-Phospho-MLKL (Ser358) Antibody (8V821)
产品编号 TMAH-00928
别名 p-MLKL (Ser358), p-MLKL (S358), Phospho-MLKL (S358), MLKL (p-Ser358), MLKL (p-S358)

Anti-Phospho-MLKL (Ser358) Antibody (8V821) 是一种抗体，靶向 Phospho-MLKL (Ser358)。Anti-Phospho-MLKL (Ser358) Antibody (8V821) 可用于 ELISA, IHC。

Anti-Phospho-MLKL (Ser358) Antibody (8V821)

Anti-Phospho-MLKL (Ser358) Antibody (8V821)

Rating icon 还可以
Anti-Phospho-MLKL (Ser358) Antibody (8V821)
产品编号 TMAH-00928 别名 p-MLKL (Ser358), p-MLKL (S358), Phospho-MLKL (S358), MLKL (p-Ser358), MLKL (p-S358)

Anti-Phospho-MLKL (Ser358) Antibody (8V821) 是一种抗体，靶向 Phospho-MLKL (Ser358)。Anti-Phospho-MLKL (Ser358) Antibody (8V821) 可用于 ELISA, IHC。

规格价格库存数量
50 μL
¥ 1,305
5日内发货
100 μL
¥ 2,185
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-MLKL (Ser358) Antibody (8V821) is an antibody targeting Phospho-MLKL (Ser358). Anti-Phospho-MLKL (Ser358) Antibody (8V821) can be used in ELISA, IHC.
别名p-MLKL (Ser358), p-MLKL (S358), Phospho-MLKL (S358), MLKL (p-Ser358), MLKL (p-S358)
Ig Type
Rabbit IgG
克隆号
8V821
交叉反应
Human
验证活性
IHC image of TMAH-00928 diluted at 1:100 and staining in paraffin-embedded human melanoma cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
应用
ELISA
IHC
推荐剂量
IHC:1:50-1:200.
抗体种类
Monoclonal
亚细胞定位Cytoplasm. Cell membrane. Nucleus.
构建方式Recombinant Antibody
纯化方式Affinity-chromatography
性状Liquid
缓冲液Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Does not have protein kinase activity. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following activation by ZBP1, MLKL is phosphorylated by RIPK3 in the nucleus, triggering disruption of the nuclear envelope and leakage of cellular DNA into the cytosol.following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol. Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
A synthetic peptide: Human Phospho-MLKL (S358)
抗原种属
Human
基因ID
197259
Uniprot ID
Q8NB16
研究领域
Signal Transduction
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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关键词

pMLKL (Ser358)pMLKL (S358)MLKL (pSer358)MLKL (pS358)MLKL (phospho-Ser358)MLKL (phospho-S358)MLKLMixed lineage kinase domain-like proteinhMLKL

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