Anti-p53 Antibody (4F836)

Name: Anti-p53 Antibody (4F836)
Brand: TargetMol
SKU: TMAH-01199
Rating: 4.5 (1 reviews)

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产品编号 TMAH-01199

Anti-p53 Antibody (4F836) 是一种 Mouse 抗体，靶向 p53。Anti-p53 Antibody (4F836) 可用于 ELISA,IHC,WB。

Anti-p53 Antibody (4F836)

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产品编号 TMAH-01199

Anti-p53 Antibody (4F836) 是一种 Mouse 抗体，靶向 p53。Anti-p53 Antibody (4F836) 可用于 ELISA,IHC,WB。

规格	价格	库存	数量
50 μg	¥ 1,305	5日内发货
100 μg	¥ 2,180	5日内发货

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产品描述	Anti-p53 Antibody (4F836) is a Mouse antibody targeting p53. Anti-p53 Antibody (4F836) can be used in ELISA,IHC,WB.
Ig Type	IgG
克隆号	4F836
交叉反应	Human
验证活性	1. Immunohistochemical of paraffin-embedded Human lung cancer tissue using TMAH-01199 at dilution of 1:200. 2. Immunohistochemical of paraffin-embedded Human rectum cancer tissue using TMAH-01199 at dilution of 1:200. 3. Immunohistochemical of paraffin-embedded Human breast cancer tissue using TMAH-01199 at dilution of 1:200. 4. Western Blot -All lanes:Mouse anti human tumor protein p53 Monoclonal antibody at 1μg/ml -Lane 1:Whole HEK-293 cells Lysates -Secondary Goat polyclonal to Mouse IgG at 1/5000 dilution -Predicted band size:43,38,39,40,34,35,30,24,25KD -Observed band size:53KD
应用	ELISA IHC WB
抗体种类	Monoclonal
宿主来源	Mouse
亚细胞定位	Cytoplasm. Nucleus. Nucleus, PML body. Endoplasmic reticulum. Mitochondrion matrix. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.; [Isoform 1]: Nucleus. Cytoplasm. Note=Predominantly nuclear but localizes to the cytoplasm when expressed with isoform 4.; [Isoform 2]: Nucleus. Cytoplasm. Note=Localized mainly in the nucleus with minor staining in the cytoplasm.; [Isoform 3]: Nucleus. Cytoplasm. Note=Localized in the nucleus in most cells but found in the cytoplasm in some cells.; [Isoform 4]: Nucleus. Cytoplasm. Note=Predominantly nuclear but translocates to the cytoplasm following cell stress.; [Isoform 7]: Nucleus. Cytoplasm. Note=Localized mainly in the nucleus with minor staining in the cytoplasm.; [Isoform 8]: Nucleus. Cytoplasm. Note=Localized in both nucleus and cytoplasm in most cells. In some cells, forms foci in the nucleus that are different from nucleoli.; [Isoform 9]: Cytoplasm.
组织特异性	Ubiquitous. Isoforms are expressed in a wide range of normal tissues but in a tissue-dependent manner. Isoform 2 is expressed in most normal tissues but is not detected in brain, lung, prostate, muscle, fetal brain, spinal cord and fetal liver. Isoform 3
构建方式	Hybridoma Monoclonal Antibody
纯化方式	Protein G purified
性状	Liquid
缓冲液	Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4.
纯度	>95%
研究背景	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2. However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2.