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顶部生物活性储存和溶解信息计算器

Anti-JAK2 Antibody (1B619)

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Anti-JAK2 Antibody (1B619)
产品编号 TMAC-02269

Anti-JAK2 Antibody (1B619) 是一种 Rabbit 抗体，靶向 JAK2。Anti-JAK2 Antibody (1B619) 可用于 WB,ICC/IF,IP。

Anti-JAK2 Antibody (1B619)

Anti-JAK2 Antibody (1B619)

Rating icon 还可以
Anti-JAK2 Antibody (1B619)
产品编号 TMAC-02269

Anti-JAK2 Antibody (1B619) 是一种 Rabbit 抗体，靶向 JAK2。Anti-JAK2 Antibody (1B619) 可用于 WB,ICC/IF,IP。

规格价格库存数量
50 μL
¥ 1,495
5日内发货
100 μL
¥ 2,480
5日内发货
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产品介绍

生物活性
产品描述
Anti-JAK2 Antibody (1B619) is a Rabbit antibody targeting JAK2. Anti-JAK2 Antibody (1B619) can be used in WB,ICC/IF,IP.
Ig Type
IgG
交叉反应
Human,Mouse,Rat
验证活性
1. ICC staining JAK2 in A549 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
2. ICC staining JAK2 in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
3. ICC staining JAK2 in NIH/3T3 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
4. All lanes use the Antibody at 1:3K dilution for 1 hour at room temperature.
应用
WB
ICC/IF
IP
推荐剂量
WB: 1:500-2000; ICC/IF: 1:50-200; IP: 1:50-100
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景JAK2 (Janus kinase 2) belongs to the emerging family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK2. JAK2 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. The canonical JAK/Stat pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival and host resistance to pathogens. Altering JAK/Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for inflammatory therapies.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
Uniprot ID
O60674
化学信息
分子量Theoretical: 130 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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关键词

Tyrosine-protein kinase JAK2Janus kinase 2 (JAK-2)JAK-2JAK2JAK 2

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