Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NS309 是选择性钙依赖性钾离子通道 SK/IK 的激活剂,在 BK 通道上没有激活作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 186 | 现货 | ||
5 mg | ¥ 398 | 现货 | ||
10 mg | ¥ 563 | 现货 | ||
25 mg | ¥ 1,080 | 现货 | ||
50 mg | ¥ 1,970 | 现货 | ||
100 mg | ¥ 2,480 | 现货 | ||
200 mg | ¥ 3,720 | 现货 | ||
500 mg | ¥ 5,880 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 449 | 现货 |
产品描述 | NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 μM for SK channels and 10-90 nM for IK channels). It can also activate voltage-gated Kv11.1 channels (hERG; IC50 = 1 μM), but does not, however, affect large conductance (BK/KCa1.1) channels. NS309 can modulate neuronal firing patterns by enhancing SK-mediated hyperpolarizing effects. It is 730-fold (SK channels) and 7,400-fold (IK channels) more potent than 1-EBIO and often used in conjunction with CyPPA to distinguish between SK1 and SK3 subtypes. |
靶点活性 | ERG (human):1 µM |
分子量 | 231.04 |
分子式 | C8H4Cl2N2O2 |
CAS No. | 18711-16-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (216.41 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 4.3283 mL | 21.6413 mL | 43.2825 mL | 108.2064 mL |
5 mM | 0.8657 mL | 4.3283 mL | 8.6565 mL | 21.6413 mL | |
10 mM | 0.4328 mL | 2.1641 mL | 4.3283 mL | 10.8206 mL | |
20 mM | 0.2164 mL | 1.0821 mL | 2.1641 mL | 5.4103 mL | |
50 mM | 0.0866 mL | 0.4328 mL | 0.8657 mL | 2.1641 mL | |
100 mM | 0.0433 mL | 0.2164 mL | 0.4328 mL | 1.0821 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
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