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3,5,7,3′,4′-Pentamethoxyflavone

Name: 3,5,7,3′,4′-Pentamethoxyflavone
Brand: TargetMol
SKU: TN2121
Price: 535 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.73%

货号 TN2121Cas号 1247-97-8

别名 栎精-3,5,7,3',4'-五甲醚, 槲皮素3,5,7,3',4'-五甲基醚, Quercetin 3,5,7,3,4-pentamethyl ether

3,5,7,3′,4′-Pentamethoxyflavone (Quercetin 3,5,7,3,4-pentamethyl ether) 是一种分离自小花山奈中的多甲氧基黄酮。在分化早期，它可以调控转录因子，促进 3T3-L1 前脂肪细胞形成脂肪。

为众多的药物研发团队赋能，

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3,5,7,3′,4′-Pentamethoxyflavone

一键复制产品信息

很棒

纯度: 99.73%

货号 TN2121 别名 栎精-3,5,7,3',4'-五甲醚, 槲皮素3,5,7,3',4'-五甲基醚, Quercetin 3,5,7,3,4-pentamethyl etherCas号 1247-97-8

规格	价格	库存
1 mg	¥ 535	现货
5 mg	¥ 1,230	现货
10 mg	¥ 1,980	现货
25 mg	¥ 3,370	现货
1 mL x 10 mM (in DMSO)	¥ 987	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.73%

颜色: 白色

性状: Solid

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产品介绍

3,5,7,3′,4′-Pentamethoxyflavone AI Summary

3,5,7,3′,4′-Pentamethoxyflavone has demonstrated diverse bioactivities and promising pharmacological potential across multiple assays. It acts as a maxi-K channel opener with 94.6% activity at 20 µM and shows significant phosphodiesterase inhibitory activity, particularly cAMP and cGMP flow in rat brain cytosolic and particulate extracts, respectively. It also exhibits cytotoxicity against human KB cells with an ED50 of 25.0 µg/ml and promotes adipogenesis and glucose uptake in mouse 3T3L1 cells. Additionally, 3,5,7,3′,4′-Pentamethoxyflavone shows potential as a multidrug resistance modulator, inhibiting MRP1, p-glycoprotein, and BCRP, possibly aiding in cancer treatments. It also displays activities as an inhibitor of various enzymes and pathways including JMJD2E, TDP1, ALDH1A1, the ERK signaling pathway, and the Menin-MLL interaction, among others. Furthermore, 3,5,7,3′,4′-Pentamethoxyflavone has pharmacokinetic properties indicative of moderate to high oral bioavailability and rapid clearance in Wistar rats. It exhibits low bioavailability in excretion but has broad tissue distribution. Notably, 3,5,7,3′,4′-Pentamethoxyflavone has potential as a thrombin inhibitor and shows weak inhibition of Influenza A virus polymerase activity. Finally, it has antioxidant properties and demonstrates antiproliferative effects on human MDA-MB-231 cells..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	3,5,7,3′,4′-Pentamethoxyflavone (Quercetin 3,5,7,3,4-pentamethyl ether) is a natural product. It can induce adipogenesis on 3T3-L1 preadipocytes by regulating transcription factors at an early stage of differentiation.
别名	栎精-3,5,7,3',4'-五甲醚, 槲皮素3,5,7,3',4'-五甲基醚, Quercetin 3,5,7,3,4-pentamethyl ether

化学信息

分子量	372.37
分子式	C₂₀H₂₀O₇
CAS No.	1247-97-8
Smiles	COc1cc(OC)c2c(c1)oc(-c1ccc(OC)c(OC)c1)c(OC)c2=O
密度	1.29 g/cm3

储存&溶解度

存储

keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 30 mg/mL (80.57 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.37 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6855 mL	13.4275 mL	26.8550 mL	134.2750 mL
5 mM	0.5371 mL	2.6855 mL	5.3710 mL	26.8550 mL
10 mM	0.2686 mL	1.3428 mL	2.6855 mL	13.4275 mL
20 mM	0.1343 mL	0.6714 mL	1.3428 mL	6.7138 mL
50 mM	0.0537 mL	0.2686 mL	0.5371 mL	2.6855 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

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3,5,7,3′,4′-Pentamethoxyflavone

3,5,7,3′,4′-Pentamethoxyflavone