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3,5-dimethyl-4-phenyl-1,2-oxazole

Name: 3,5-dimethyl-4-phenyl-1,2-oxazole
Brand: TargetMol
SKU: T50075
Price: 351 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.54%

货号 T50075Cas号 4345-46-4

3,5-dimethyl-4-phenyl-1,2-oxazole 是一种用作分子结构单元的杂环化合物，具有抗炎、抗肿瘤、抗细菌和抗真菌活性，以及调节免疫系统的能力。

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3,5-dimethyl-4-phenyl-1,2-oxazole

一键复制产品信息

很棒

纯度: 99.54%

货号 T50075Cas号 4345-46-4

3,5-dimethyl-4-phenyl-1,2-oxazole 是一种用作分子结构单元的杂环化合物，具有抗炎、抗肿瘤、抗细菌和抗真菌活性，以及调节免疫系统的能力。

规格	价格	库存
1 mg	¥ 351	现货
5 mg	¥ 805	现货
10 mg	¥ 1,210	现货
25 mg	¥ 2,000	现货
50 mg	¥ 2,860	现货
100 mg	¥ 3,880	现货
200 mg	¥ 5,230	现货
1 mL x 10 mM (in DMSO)	¥ 583	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.54%

颜色: 白色

性状: Solid

联系我们获取更多批次信息

资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

3,5-dimethyl-4-phenyl-1,2-oxazole AI Summary

3,5-dimethyl-4-phenyl-1,2-oxazole exhibits bioactivity related to bromodomain-containing proteins and demonstrates inhibitory effects on BRD2, BRD3, and BRD4. It moderately displaces the H4Ac4 peptide from the first bromodomain of human BRD4 and BRD2, with IC50 values of 84200.0 nM and 34300.0 nM, respectively. The compound shows binding affinities to multiple bromodomains including BRD2, BRD3, BRD4, as well as other proteins such as BAZ2B and CREBBP, as indicated by changes in melting temperature in differential scanning fluorimetry assays. In fluorescence anisotropy assays, 3,5-dimethyl-4-phenyl-1,2-oxazole inhibits His6-tagged BRD3 and BRD4 proteins expressed in Escherichia coli by 32.0% and 26.0% respectively, after 60 minutes. It also exhibits anti-cancer properties through the inhibition of BRD4-mediated c-myc mRNA expression in human HT-29 cells, displacement of FITC-labeled (+)-JQ1 from bromodomain BRD4(1), and growth inhibition of HT-29 cells. The IC50 for BRD4 inhibition, as shown by a biotinylated-JQ1 based AlphaScreen BRD binding assay, is 65000.0 nM. Furthermore, 3,5-dimethyl-4-phenyl-1,2-oxazole inhibits BRD4 BD2 and BRD4 BD1 with IC50 values of 158489.32 nM and 50118.72 nM, respectively, suggesting its potential to modulate the activities of these bromodomains..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	3,5-dimethyl-4-phenyl-1,2-oxazole is a heterocyclic compound used as a molecular structural unit. It has anti-inflammatory, anti-tumor, anti-bacterial and anti-fungal activity, as well as the ability to modulate the immune system.

化学信息

分子量	173.21
分子式	C₁₁H₁₁NO
CAS No.	4345-46-4
Smiles	CC=1C(=C(C)ON1)C2=CC=CC=C2
密度	1.060 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (288.67 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.7733 mL	28.8667 mL	57.7334 mL	288.6669 mL
5 mM	1.1547 mL	5.7733 mL	11.5467 mL	57.7334 mL
10 mM	0.5773 mL	2.8867 mL	5.7733 mL	28.8667 mL
20 mM	0.2887 mL	1.4433 mL	2.8867 mL	14.4333 mL
50 mM	0.1155 mL	0.5773 mL	1.1547 mL	5.7733 mL
100 mM	0.0577 mL	0.2887 mL	0.5773 mL	2.8867 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

3,5-dimethyl-4-phenyl-1,2-oxazole 3,5dimethyl4phenyl1,2oxazole 3,5 dimethyl 4 phenyl 1,2 oxazole

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3,5-dimethyl-4-phenyl-1,2-oxazole

3,5-dimethyl-4-phenyl-1,2-oxazole