signal peptidase ii (lspa)

Globomycin, a lipopeptide antibiotic, is an inhibitor of signal peptidase II (LspA). It binds irreversibly to the peptidase, thereby inhibiting the processing of the prolipoprotein.

Globomycin derivative G2A (Compound G2A) 是一种抑制脂蛋白信号肽酶 II (LspA) 的化合物，其IC50为604 nM。该化合物对E. coli、P. aeruginosa和A. baumannii表现出抑制作用，最低抑菌浓度（MIC）范围为12.5至32 μg/mL。