pmn

AZ084 是可口服的选择性 CCR8变构拮抗剂，其Ki 值为 0.9 nM，可研究哮喘。

6-OAU (GTPL5846) 是 GPR84 的替代激动剂，在 Gqi5 嵌合体存在的情况下，在 HEK293 细胞中激活人 GPR84，在 PI 测定中 EC50 为 105 nM。

CU-6PM is a new fluorescent RXR agonist. CU-6PMN was designed based on the fact that umbelliferone emits strong fluorescence in a hydrophilic environment, but the fluorescence intensity decreases in hydrophobic environments such as the interior of proteins. The developed assay CU-6PMN enabled screening of rexinoids to be performed easily within a few hours by monitoring changes of fluorescence intensity with widely available fluorescence microplate readers, without the need for processes such as filtration.

PMN310 是一种单克隆抗体，专门针对 β 淀粉样蛋白低聚物 (AβO)。在体内，PMN310 能够预防由 AβO 诱导的记忆形成丧失，并减少突触丢失和炎症反应。PMN310 可用于阿尔兹海默症的研究。

EML631 is a potent and selective SPIN1 inhibitor (SPIN1 Kd= 3 microM).

Amphotericin B (NSC-527017) 是一种多烯类抗真菌剂，对许多真菌物种具有广谱活性。Amphotericin B 不可逆地结合麦角甾醇，破坏细胞膜完整性，从而起到抗真菌活性。

Olsalazine (Dipentium) 是一种抗炎药，用于治疗炎症性肠病。它也是一种新型的 DNA 去甲基化剂。

Sialic acid aldolase (Pm NaNa) (EC 4.1.3.3) 是一种I型醛缩酶，可催化N-乙酰神经氨酸 (Neu5Ac) 的可逆裂解，生成丙酮酸和N-乙酰-D-甘露糖胺 (ManNAc)，而且反应平衡倾向于Neu5Ac的裂解。

CV-6209 是一种具有选择性和高效性的血小板活化因子 (PAF) 拮抗剂，具有抗增殖作用，部分抑制乙酰胆碱诱导的低血压，抑制 Paf 诱导的 PMN 或血小板聚集。CV-6209 具有抗幽门螺杆菌作用，可以抑制 PAF 引起的大鼠低血压。

Resolvin E1(RvE1)是一种衍生于omega-3脂肪酸二十碳五烯酸 (EPA)的内源性脂质介质，具有抗炎性，能够激活炎症消退和促进吞噬细胞的清除，可预防2,4,6-三硝基苯磺酸诱导的结肠炎，改善红细胞增生和严重再生障碍性贫血（SAA）。

D-Citrulline (H-D-Cit-OH)为L-citrulline的立体异构体。研究表明，D-Citrulline通过非NO介导机制，能有效减轻大鼠离体灌注心脏在缺血/再灌注条件下，由多形核白细胞 (PMN) 引发的心脏收缩功能障碍。

N-Formyl-MMYALF 是一种线粒体 N-甲酰肽(mtFP)， 这种化合物能有效消耗内质网中的钙离子。此外，N-Formyl-MMYALF 还能抑制 FPR-1 介导的 PMN 对细菌肽的趋化反应。

N-Formyl-MMYALF TFA 是一种对内质网钙离子具有消耗活性的线粒体N-甲酰肽。此化合物能够抑制FPR-1介导的PMN对细菌肽的趋化反应。

Antibacterialagent 284 (Compound 7) 是一种抗菌剂，含有锌结合结构，对嗜肺军团菌 (Legionella pneumophila) 金属蛋白酶 ProA 的抑制活性强，IC50 为 0.96 μM。它能显著抑制 IV 型胶原蛋白和鞭毛蛋白 (ProA 底物) 的裂解，并在减少人肺组织外植体中 TLR5-NF-κB 通路免疫逃逸和中性粒细胞 (PMN) 介导的炎症方面表现出色。Antibacterialagent 284 在军团病研究中具有潜在应用价值。

inhibits leukotriene B4 (LTB4)-induced polymorphonuclear neutrophils (PMN) chemotaxis

SX-517是一种非竞争性的CXCR1/2的双重拮抗剂，在PMN细胞和小鼠模型中均能够抑制炎症。SX-517能够抑制CXCL-1诱导的Ca2+通量(IC50=38 nM)，拮抗CXCL-8诱导的[(35)S]GTPγS结合作用(IC50=60 nM)和ERK1/2磷酸化。

TCV-309 is an inhibitor of platelet activating factor (PAF). TCV-309 reduces graft PMN infiltration and enhances early function of 24-hour-preserved rat kidneys with long warm ischemia. TCV-309 attenuates the priming effects of bronchoalveolar macrophages

MK-287 (L-680573) is a platelet activator (PAF) antagonist that effectively inhibates the binding of [3H]C18-PAF to human platelets, polynucleated white blood cells (PMN), and pulmonary membranes. May be used to treat asthma,

Resolvin E2 (RvE2) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.1It is produced from eicosapentaenoic acidviaan 18-HEPE intermediate, which is formed by aspirin-acetylated COX-2-mediated oxidation of EPA, by 5-lipoxygenase (5-LO) in human polymorphonuclear (PMN) neutrophils.2,3RvE2 (20 ng/animal) inhibits increases in inflammatory exudate neutrophil infiltration in a mouse model of peritonitis induced by zymosan A .3Hepatic RvE2 levels are increased in mice fed normal chow, as well as in a mouse model of high-fat diet-induced non-alcoholic fatty liver disease (NAFLD), by dietary supplementation with EPA.4Plasma levels of RvE2 are increased by dietary supplementation with fish oil containing ω-3 polyunsaturated fatty acids (PUFAs) in patients with peripheral artery disease or chronic kidney disease.1,5,6 1.Chiang, N., and Serhan, C.N.Specialized pro-resolving mediator network: An update on production and actionsEssays Biochem.64(3)443-462(2020) 2.Tjonahen, E., Oh, S.F., Siegelman, J., et al.Resolvin E2: Identification and anti-inflammatory actions: Pivotal role of human 5-lipoxygenase in resolvin E series biosynthesisChemistry & Biology131193-1202(2006) 3.Sungwhan, F.O., Pillai, P.S., Recchiuti, A., et al.Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammationJ. Clin. Invest.121(2)569-581(2011) 4.Echeverría, F., Valenzuela, R., Espinosa, A., et al.Reduction of high-fat diet-induced liver proinflammatory state by eicosapentaenoic acid plus hydroxytyrosol supplementation: Involvement of resolvins RvE1/2 and RvD1/2J. Nutr. Biochem.6335-43(2019) 5.Ramirez, J.L., Gasper, W.J., Khetani, S.A., et al.Fish oil increases specialized pro-resolving lipid mediators in PAD (the OMEGA-PAD II trial)J. Surg. Res.238164-174(2019) 6.Barden, A.E., Shinde, S., Burke, V., et al.The effect of n-3 fatty acids and coenzyme Q10 supplementation on neutrophil leukotrienes, mediators of inflammation resolution and myeloperoxidase in chronic kidney diseaseProstaglandins Other Lipid Mediat.1361-8(2018)

Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid.[1] In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.[2] Resolvin D1 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase.[1] 17(R)-RvD1 is an aspirin-triggered epimer of RvD1 that reduces human polymorphonuclear leukocyte (PMN) transendothelial migration, the earliest event in acute inflammation, with equipotency to RvD1 (EC50 = ~30 nM).[3] 17(R)-RvD1 exhibits a dose-dependent reduction in leukocyte infiltration in a mouse model of peritonitis with maximal inhibition of ~35% at a 100 ng dose.[3] In contrast to RvD1, the aspirin-triggered form resists rapid inactivation by eicosanoid oxidoreductases. Analytical and biological comparisons of synthetic 17(R)-RvD1 with endogenously derived 17(R)-RvD1 have confirmed its identity as matching the natural product.[4]

17(R)-Protectin D1 is an aspirin-triggered epimer of the specialized pro-resolving mediator protectin D1 .1It decreases leukotriene B4-induced transendothelial migration of human polymorphonuclear (PMN) neutrophils when used at concentrations ranging from 0.1 to 10 nM. 17(R)-Protectin D1 (0.01-10 ng) reduces the recruitment of neutrophils in a mouse model of TNF-α-induced peritonitis. 1.Serhan, C.N., Fredman, G., Yang, R., et al.Novel proresolving aspirin-triggered DHA pathwayChem. Biol.18(18)976-987(2011)

Resolvin conjugate in tissue regeneration 1 (RCTR1) is a specialized pro-resolving mediator (SPM) biosynthesized from docosahexaenoic acid by isolated human macrophages and apoptotic polymorphonuclear (PMN) neutrophils.1It has been found in human spleen and bone marrow.2RCTR1 is produced via lipoxygenase-mediated oxidation of DHA to 7(S)-8-epoxy-17(S)-HDHA, which is conjugated to glutathione.1,2,3RCTR1 (10 nM) increases phagocytosis ofE. colior apoptotic neutrophils in isolated human monocyte-derived macrophages.2It decreases chemotaxis induced by leukotriene B4in isolated human neutrophils when used at a concentration of 10 nM. RCTR1 (1 and 10 nM) accelerates tissue regeneration in planaria. Intraperitoneal administration of RCTR1 (100 ng/animal) shortens the inflammatory resolution period and decreases inflammatory exudate neutrophil infiltration in a mouse model ofE. coli-induced peritonitis. 1.Dalli, J., Ramon, S., Norris, P.C., et al.Novel proresolving and tissue-regenerative resolvin and protectin sulfido-conjugated pathwaysFASEB J.29(5)2120-2136(2015) 2.de la Rosa, X., Norris, P.C., Chiang, N., et al.Identification and complete stereochemical assignments of the new resolvin conjugates in tissue regeneration in human tissues that stimulate proresolving phagocyte functions and tissue regenerationAm. J. Pathol.188(4)950-966(2018) 3.Rodriguez, A.R., and Spur, B.W.First total synthesis of pro-resolving and tissue-regenerative resolvin sulfido-conjugatesTetrahedron Lett.58(16)1662-1668(2017)

Docosahexaenoic acid is a nutritionally-derived ω-3 fatty acid that is abundant in the brain and the retina and is thought to be important in early development and for therapeutic approaches to inflammatory disorders and cancer. 14(S)-HDHA is an oxygenation product of DHA that serves as a precursor to maresin 1 , an anti-inflammatory, pro-resolving mediator that prevents polymorphonuclear neutrophil (PMN) infiltration and stimulates macrophage phagocytosis. At doses as low as 0.2 ng/mouse 14(S)-HDHA administration resulted in reduced infiltration of PMNs into sites of inflammation.

Lipoxin B4是花生四烯酸的代谢产物，能够抑制上呼吸道中的鼻粘膜中的白细胞浸润和粘液分泌，具有粘膜保护作用，常用于研究上、下呼吸道的过敏性炎症。