linezolid

Linezolid (PNU-100766) 是恶唑烷酮类合成抗生素，抑制细菌蛋白质合成的起始阶段，具有抗感染作用。

Linezolid D3, a deuterium-labeled version of Linezolid, is a synthetic antibiotic designed to halt the initiation of bacterial protein synthesis.

Demethyl linezolid is an impurity observed in linezolid, an antimicrobial compound. It exhibits effective antimicrobial properties against various human and veterinary pathogens.

(R)-Linezolid, an impurity of Linezolid, inhibits the initiation of bacterial protein synthesis.

PNU-100440 是一种生物活性化合物。它是合成利奈唑胺二聚物的中间体，利奈唑胺二聚物是抗菌剂利奈唑胺的杂质。

Radezolid (RX-1741) 是一种噁唑烷酮类抗生素。它对衣原体，军团菌葡萄球菌，和Linezolid 耐药菌株有活性。

Tedizolid HCl is a reversible, novel oxazolidinone antibiotic (IC50: for MAO-A (monoamine oxidase-A), 8.7 uM; for MAO-B, 5.7 uM). It is the first oxazolidinone to be approved since linezolid in 2000. Tedizolid phosphate is the second commercially availabl

DA-7867 is a novel oxazolidinone. DA-7867 had the lowest MIC for 90% of the aerobic gram-positive bacterial strains tested (≤0.25 μg ml) and it was more potent than linezolid. DA-7867 was the most active drug with a MIC(90) of 0.125 μg ml.

Lytixar is a Synthetic Antimicrobial Peptide, it shows activity against Daptomycin-Nonsusceptible, Methicillin-Resistant, Vancomycin-Intermediate, Vancomycin-Resistant, and Linezolid-Nonsusceptible Staphylococcus aureus. LTX-109 demonstrated a MIC range o

CAY10742 is an orally bioavailable oxadiazole antibiotic.1It is active against the Gram-positive bacteriaS. aureus,S. epidermidis,S. haemolyticus,B. cereus,B. licheniformis,E. faecalis, andE. faecium(MICs = 1-4 μg/ml), including laboratory strains and clinical isolates with varying degrees of resistance to methicillin, vancomycin, linezolid, and other antibiotics. CAY10742 (40 mg/kg) reduces the number of bacteria in mouse neutropenic thigh models of linezolid-sensitive or -resistant methicillin-resistantS. aureus(MRSA) infection. 1.Boudreau, M.A., Ding, D., Meisel, J.E., et al.Structure-activity relationship for the oxadiazole class of antibacterialsMed. Chem. Lett.11(3)322-326(2019)

PNU 142300 is an inactive metabolite of the oxazolidinone antibiotic linezolid .

Delpazolid (LCB01-0371) 是一种恶唑烷酮类新型抗生素，能抑制MSSA 和MRSA 的生长，对它们的MIC90值都为 2 μg mL。

YycG inhibitor 16 is a novel YycG inhibitor, inhibiting planktonic cells of E. faecalis, including the vancomycin- or linezolid-resistant strains.

Suvratoxumab (MEDI4893) 是一种长效且具有亲和力高的人源化抗 α-毒素单克隆抗体(IgG1κ 型)。Suvratoxumab 能有效中和 α-毒素 (一种关键的金黄色葡萄球菌毒力因子)。Suvratoxumab 可提高免疫功能低下的小鼠肺炎模型的存活率并减少肺损伤。Suvratoxumab 还可增强Vancomycin 或Linezolid 的抗菌活性。

BDM88855 hydrochloride 作为同源AcrB蛋白的变构抑制剂，能够提升多种抗生素（例如：苯唑西林、利奈唑胺、新生霉素）对野生型大肠杆菌的抗菌效果。

BDM88855 作为同源AcrB蛋白的变构抑制剂，能够提升多种抗生素（例如：苯唑西林、利奈唑胺、新生霉素）针对野生型大肠杆菌的抗菌效果。

(S)-N-Glycidylphthalimide (2-[(2S)-2-Oxiranylmethyl]-1H-isoindole-1,3(2H)-dione) 是一种邻苯二甲酰亚胺衍生物，用作制备抗生素利奈唑胺的中间体。