hemiasterlin

Hemiasterlin is a cytotoxic peptide that acts by inducing mitotic arrest and abnormal spindle formation.

Hemiasterlin Derivative-1, a derivative of hemiasterlin, is utilized in the synthesis of Antibody-Drug Conjugates (ADC).

SPA107 (Hemiasterlin methyl ester) 是 Hemiasterlin 的类似物。它能够抑制微管蛋白 (tubulin) 的聚合，显示出抗有丝分裂活性（IC50 为 0.5 nM），并对 p53 突变的 MCF-7 细胞具有细胞毒性，IC50 为 0.5 nM。

Taltobulin trifluoroacetate is a synthetic analogue of the tripeptide hemiasterlin, is a potent agent of antimicrotubule that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.

Taltobulin hydrochloride is a synthetic analogue of the tripeptide hemiasterlin, is a potent agent of antimicrotubule that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.

E7974 is an analog of the sponge-derived anti-microtubule tripeptide hemiasterlin with antimitotic and potential antineoplastic activities. Hemiasterlin analog E7974 binds to the Vinca domain on tubulin, resulting in inhibition of tubulin polymerization and microtubule assembly; depolymerization of exsiting microtubules; inhibition of mitosis; and inhibition of cellular proliferation. This agent may have more affinity for the beta-3 tubulin isotype. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

Taltobulin hydrochloride (HTI-286 hydrochloride) 是一种合成的三肽半胱氨酸类似物，为高效抗微管剂，能够在体内外绕过P-糖蛋白介导的药物耐药性。该化合物通过抑制微管蛋白的聚合和破坏细胞内微管结构，进而引起细胞有丝分裂停滞和细胞凋亡。

SC239为一种2-氨基苯基半紫杉烷类活性分子连接剂，具有可裂解特性。该化合物适用于抗体药物偶联物（ADC）的活性分子连接。