haloperidol

Haloperidol (Serenace) 是一种安定药，是一种dopamine D2 receptor 拮抗剂。

Reduced Haloperidol-d4 是 Reduced Haloperidol 的氘代化合物。Reduced Haloperidol 的 CAS 号为 34104-67-1。

Haloperidol lactate 是一种有效的抗精神病药。Haloperidol lactate 具有潜力进行精神障碍的研究。Haloperidol lactate 能够用于急性和慢性精神分裂症和多发性秽语综合征。

Reduced haloperidol is an active metabolite of haloperidol . It is formed via reduction of haloperidol by ketone reductase. Reduced haloperidol inhibits radioligand binding to sigma-1 and dopamine D2 receptors (Kis = 1.4 and 31 nM, respectively) and stimulates brain-derived neurotrophic factor (BDNF) secretion from CCF-SSTG1 and U87MG astrocytic glial cells. It also inhibits norepinephrine, dopamine, and serotonin (5-HT) reuptake (Kis = 21, 25, and 33 μM, respectively, in COS-7 cells expressing the human transporters). Reduced haloperidol (0.5 mg kg) increases latency to paw withdrawal in mouse models of capsaicin- but not force-induced mechanical hypersensitivity.

Haloperidol hydrochloride 是一种有效的 dopamine D2 receptor 拮抗剂，广泛用作抗精神病药

Haloperidol decanoate (KD 16) 是一种典型的抗精神病药物，用作精神分裂症和情绪障碍的维持治疗，配制成用于肌肉注射的酯。

Haloperidol-d4 TFA 是 Haloperidol TFA 的氘代化合物。

Haloperidol D4' is deuterium-labeled haloperidol. Haloperidol is a dopamine D2 receptor antagonist.

Haloperidol D4 is deuterium-labeled haloperidol.

Palmitoyl glutamic acid (N-Palmitoyl-L-glutamic acid) 是一种酰基氨基酸，可阻断主动脉收缩,可拮抗由氟哌啶醇诱发的口腔运动障碍。Palmitoyl glutamic acid 常常添加在化妆品中。

Raseglurant (ADX-10059) 作为一种mGlu5 受体负变构调节剂，具有抵抗偏头痛的有效性。此外，该化合物还能减轻小鼠中由Haloperidol引发的僵住症状。

Ro 04-5595 is a selective antagonist of NMDA receptors NR2B subunits. Ro 04-5595 had an EC 50 of 186 ± 32 nmol L. Ro 04-5595 was predicted to bind the EVT-101 binding site, not the ifenprodil-binding site. Specific binding, defined with a new NR2B-specific antagonist Ro 04-5595 at 10 microM was fully inhibited by several compounds with the following rank order of affinities--Ro 25-6981 > CP-101,606 > Ro 04-5595 = ifenprodil >> eliprodil > haloperidol > spermine > spermidine > MgCl2 > CaCl2--and partially inhibited by competitive glutamate recognition site antagonists. Complementary high-resolution autoradiographic images using [3H]Ro04-5595 demonstrated strong binding in NR2B receptor-rich regions and low binding in cerebellum where NR2B concentration is low.

Spiperone (Spiropitan) 是多巴胺 D2、血清素5-HT1A 和血清素5-HT2A 拮抗剂。它是广泛使用的药理学工具。它具有研究神经系统疾病的潜力。

(S)-(-)-MRJF22为氟哌啶醇代谢物II丙戊酸酯，展现了强效的抗迁移活性，尤其在内皮细胞和肿瘤细胞中。作为一种多功能活性分子，(S)-(-)-MRJF22对葡萄膜黑色素瘤具有潜在疗效。

Antibacterial agent 67 能够显著抑制琥珀酸脱氢酶的活性，IC50 值为 0.03 μM，且对琥珀酸脱氢酶的酶抑制活性显著比氟哌啶醇（IC50= 4.40 μM）高。

VU0477886 is a potent mGlu4 positive allosteric modulator (PAM) with robust efficacy in a standard preclinical Parkinson's disease model, haloperidol-induced catalepsy (HIC).

Acetyl β-endorphin (1-26) is a neuropeptide found in rat hippocampus, brain stem, and pituitary. It is also present in the human hypothalamus, where it comprises approximately 4.9% of total β-endorphin peptides. Acetyl β-endorphin (1-26) is produced through posttranslational processing of β-endorphin and is processed similarly in rat and human hypothalamus. Levels of acetyl β-endorphin (1-26) increase in the rat pars intermedia and brain stem following chronic administration of haloperidol .

Carpipramine (free base) 在法国和日本用作治疗精神分裂症和焦虑的非典型抗精神病化合物。该化合物除具有神经抑制和抗焦虑效果外，还具有催眠特性。从结构上看，carpipramine 既与三环类化合物如imipramine相似，也与丁酰苯类化合物如haloperidol相关。