gz-a

Wangzaozin A是一种具有细胞毒性的对映贝壳杉烯二萜类化合物，其IC50值在HepG2细胞上为1.41 μM，在Tb细胞上为0.32 μM。

GZ-11608, a selective and potent inhibitor of vesicular monoamine transporter-2 (VMAT2), presents a high affinity with a Ki value of 25 nM. It effectively reduces dopamine release induced by methamphetamine from isolated synaptic vesicles in brain dopaminergic neurons. GZ-11608 also demonstrates rapid penetration into the brain without exhibiting neurotoxicity, making it a valuable compound for researching methamphetamine use disorder [1].