folate

Folic acid 是一种口服活性必需营养素，参与DNA/RNA合成及新细胞的产生与维持，具有抗抑郁样作用，能降低新生儿神经管缺陷风险，缺乏时可引起巨幼红细胞性贫血、大红细胞性贫血、神经管闭合缺陷、肿瘤及衰老等疾病，且常用于因叶酸缺乏相关疾病研究及诱导急性肾损伤模型。

Trimethoprim (NSC-106568) 是抑菌抗生素，也是具有口服活性的二氢叶酸还原酶抑制剂。它对多种革兰氏阳性和革兰氏阴性需氧细菌具有活性，可用于尿路感染，肺孢子菌肺炎和志贺氏菌病的研究。

Silver sulfadiazine (Dermazin) 是一种磺胺类抗生素，具有抗菌和抗真菌活性。它的通磺胺部分(SD-SDZ) 对细菌生长有双重抑制作用，可阻止细菌叶酸吸收以及 DNA 合成。它释放的银结合并破坏 DNA 结构，阻止细菌 DNA 复制。

DSPE-PEG46-Folate is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Folate-PEG3-azide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Hexaglutamate folate is a naturally occurring form of folic acid. The bioavailability of dietary folate may be limited by the need for the glutamate moieties to be deconjugated before absorption. Folate deficiency in humans results in anemia, neural tube

Folate sodium, as a member of the vitamin B family, can stimulate the hematopoietic system. Folic acid can be used in the treatment and prevention of folate deficiencies and megaloblastic anemia.

Triglutamate folate is a bioactive chemical.

Folate-PEG2-amine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Folate-PEG3-alkyne is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Folate-PEG3-amine is a three-unit polyethylene glycol (PEG) linker, which is cleavable. This linker is specifically employed in the synthesis of antibody-drug conjugates (ADCs).

DSPE-PEG-Folate (Mw 3350) 是一种含有叶酸的 PEG 衍生物。DSPE-PEG-Folate 具有靶向作用并能与癌细胞中的叶酸受体结合。DSPE-PEG-Folate 形成胶束 脂质双层，可用于靶向给药系统的研究。

Cholesterol-PEG-Folate (MW 2000) 是一种辅料，可用于制备叶酸偶联 PEG 脂质体。

DSPE-PEG-Folate (MW 5000) 是一种含叶酸的 PEG 衍生物，能与癌细胞的叶酸受体结合并具有靶向作用。该化合物可形成胶束 脂质双层，适用于靶向给药系统的研究。

Folate-MS432作为PROTAC，通过叶酸受体依赖途径特异性降解癌细胞中的MEKs。

DSPE-PEG-Folate, MW 2000 是一种包含叶酸的 PEG 衍生物，具有靶向性，能结合癌细胞中的叶酸受体。它能够形成胶束或脂质双层，适用于靶向给药系统的研究。

Cholesterol-PEG-Folate (MW 1000) 是一种胆固醇 PEG 衍生物，通过分子自组装可以形成胶束，并在体内呈现较长的半衰期。Cholesterol-PEG-Folate (MW 1000) 适用于药物递送的研究。

Cholesterol-PEG-Folate (MW 3400) 是一种胆固醇 PEG 衍生物，可通过分子自组装形成胶束，并在体内具备较长的半衰期，适用于药物递送的研究。

Cholesterol-PEG-Folate (MW 5000) 是一种胆固醇 PEG 衍生物，能通过分子自组装生产胶束，且在体内半衰期较长。Cholesterol-PEG-Folate (MW 5000) 适用于药物递送研究。

Folinic Acid Calcium Salt Pentahydrate (Leucovorin Calcium Pentahydrate) 是一种还原型叶酸，是一种解毒剂，通常与甲氨蝶呤 (MTX) 联用，以降低 MTX 诱导的毒性。

Ethopabate (Ethyl pabate) 是一种用于家禽的抗原虫药。

Tetrahydrofolic acid (5,6,7,8-tetrahydrofolic acid) 是一种维生素 B9 衍生物，是生物体常见的一碳供体，参与生物体生长代谢。

EC0489, Small molecule-drug conjugate (SMDC) ,a conjugate of folic acid and desacetyl vinblastine hydrazide, is a high-affinity ligand for the folate receptor (FR). Refractory or metastatic Tumor.

LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (Ki: 6.5 nM). It also has antitumor activity.