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Anti-FOLR1 Antibody (2B73)
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产品编号 TMAY-01793
别名 FOLR, folate receptor 1 (adult), Folate Binding Protein, FBP
Anti-FOLR1 Antibody (2B73) 是一种 Mouse 抗体，靶向 FOLR1。Anti-FOLR1 Antibody (2B73) 可用于 ELISA,ELISA(Cap)。
Anti-FOLR1 Antibody (2B73)
331 Anti-FOLR1 Antibody (2B73)
还可以产品编号 TMAY-01793 别名 FOLR, folate receptor 1 (adult), Folate Binding Protein, FBP
Anti-FOLR1 Antibody (2B73) 是一种 Mouse 抗体，靶向 FOLR1。Anti-FOLR1 Antibody (2B73) 可用于 ELISA,ELISA(Cap)。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 20 μL | ¥ 585 | 5日内发货 | |
| 100 μL | ¥ 1,684 | 5日内发货 |
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产品介绍
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偶联与修饰
抗原信息
| 产品描述 | Anti-FOLR1 Antibody (2B73) is a Mouse antibody targeting FOLR1. Anti-FOLR1 Antibody (2B73) can be used in ELISA,ELISA(Cap). |
| 别名 | FOLR, folate receptor 1 (adult), Folate Binding Protein, FBP |
| Ig Type | Mouse IgG1 |
| 克隆号 | 2B73 |
| 交叉反应 | Human |
| 应用 | ELISA,ELISA(Cap) |
| 推荐剂量 | ELISA: 1:1000-1:2000; ELISA(Cap): 1:250-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human FOLR1 (rh FOLR1; TMPY-01815; NP_057937.1; Met1-Met233). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | The protein encoded by FOLR1 gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene.Folate receptor α (FRα) is the most important subunit of Folate receptor and the alpha isoform has been shown to be selectively overexpressed in cancer types like breast and ovarian cancer compared to normal breast and ovarian epithelial cells. It was determined that Folate receptor α exhibits a limited expression on the apical surfaces of the epithelial cells of normal lung, breast, thyroid, parathyroid, and kidney tissues. For their uptake of folate, normal cells rely almost exclusively on the reduced folate carrier, whereas many carcinomas and myeloid leukemia cells overexpress a high-affinity FR on their surfaces, perhaps reflecting their increased need for folate to support rapid cell division.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human FOLR1 Protein (TMPY-01815) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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