f-5446

XL-188 is a highly potent and selective inhibitor of USP7. XL188 inhibited USP7 catalytic domain and full-length enzyme with IC50 values of 193 and 90 nM, respectively. XL188 Promotes USP7-Dependent Loss of HDM2 and Increase of p53 and p21. XL188 represents one of only a small set of mammalian DUB inhibitors with low nanomolar potency and a high degree of selectivity relative to other DUBs

F5446是一种选择性的小分子SUV39H1甲基转移酶抑制剂。它通过抑制H3K9me3在FAS启动子上的沉积来增加Fas表达，同时抑制CTL效应基因表达，从而促进结直肠癌细胞凋亡。