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Targets Recommended: Adenosine Receptor

72

抑制剂 & 化合物

1

天然产物

4

化合物库

4

重组蛋白

9

同位素标记化合物

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Cat. No. Product Name
DF4000 Smart共价片段化合物库

511 compounds
ChemDiv’s Smart Library of Covalent Fragments contains 799 compounds
L9410 共价抑制剂库

1920 compounds
1920 种小分子的独特集合,包含已发现的共价抑制剂以及包含某些共价反应基团常见弹头的分子,如氯乙酰基,2-氯丙酰基,丙烯酰基,1-丙-2-炔基,1-丁-2-炔基,酮羰基,二硫键等,可以用于共价抑制剂药物研发;
L7110 抗高血压化合物库

678 compounds
678 种高血压相关的小分子,用于高通量和高内涵筛选;
DO2200 共价抑制剂库CD

12000 compounds
数量多:超过12000种共价结合化合物,并且数量在持续增加;

化合物库

Smart共价片段化合物库
Cat.No: DF4000
Compounds: 511
共价抑制剂库
Cat.No: L9410
Compounds: 1920
抗高血压化合物库
Cat.No: L7110
Compounds: 678
共价抑制剂库CD
Cat.No: DO2200
Compounds: 12000
Cat. No. Product Name Target Signaling Pathways
T16136 MRS-1706

Adenosine Receptor GPCR/G Protein; Neuroscience
MRS-1706 是一种选择性A2B 腺苷受体的反向激动剂,对人 A2B、A2A、A1和 A3受体的Ki 值分别为 1.39、112、157 和 230 nM。
T8581 Flecainide hydrochloride

Others Others
Flecainide hydrochloride 是一种用于预防和治疗异常快速心率的药物。这包括室性和室上性心动过速。
T0802 Procaine hydrochloride

Novocaine HCl,Procaine HCl,盐酸普鲁卡因

Histone Demethylase; 5-HT Receptor; DNA/RNA Synthesis; Sodium Channel; NMDAR; AChR Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
Procaine hydrochloride (Novocaine HCl) 是DNA 脱甲基剂,是一种苯甲酸衍生物,具有局部麻醉和抗心律失常特性。
T0029 Procaine

Duracaine,Spinocaine,普鲁卡因,Novocaine,Vitamin H3,奴夫卡因

Histone Demethylase; DNA/RNA Synthesis; Sodium Channel Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Membrane transporter/Ion channel
Procaine (Vitamin H3) 是DNA 脱甲基剂,是一种酯类局部麻醉剂。它起效缓慢,作用持续时间短,主要用于浸润麻醉、周围神经阻滞和脊髓阻滞。
T22371 Mivacurium dichloride

米库氯铵,Mivacurium chloride,二氯美维库铵

AChR Neuroscience
Mivacurium dichloride (Mivacurium chloride) 是苄基异喹啉衍生物,可与 nAChR 偶联,以减少或抑制乙酰胆碱对肌肉细胞末端盘的去极化作用。它也是非去极化短效的神经肌肉阻滞剂和骨骼肌松弛剂。
T20968 CyPPA

Potassium Channel; Dopamine Receptor GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
CyPPA 是hSK2和hSK3的阳性调节剂,其EC50值分别为 5.6 μM 和14 μM。它对 hSK1 和 hIK 通道无活性。
T0015 Mephenesin

Cresoxydiol,甲酚甘油醚,Memphenesin,Mephedan,Decontractyl

NMDAR; iGluR Membrane transporter/Ion channel; Neuroscience
Mephenesin (Cresoxydiol) 是 NMDA 受体拮抗剂,也是中枢性肌松弛剂。
T0916 Butamben

Butyl 4-aminobenzoate,4-氨基苯甲酸丁酯

Potassium Channel; Calcium Channel; Sodium Channel Membrane transporter/Ion channel; Metabolism
Butamben (Butyl 4-aminobenzoate) 是一种长效局部麻醉剂,用于治疗慢性疼痛。
T28829 Soquinolol

Soquinolol mucate

Adrenergic Receptor GPCR/G Protein; Neuroscience
Soquinolol (Soquinolol mucate) 是一种β肾上腺素能受体拮抗剂,具有较弱的局部麻醉活性。Soquinolol 具有良好的肠内疗效和较长的作用持续时间。
T21335 Fluorogestone acetate

Flurogestone Acetate Flugestone Acetate Fluorogesterone Acetate SC9880,氟孕酮醋酸酯

Others Others
Fluorogestone acetate 显示出高效力且活性持续时间短,并且在生理上与孕酮相似。 FGA 的效力大约是黄体酮的 20-25 倍。
T7198 E-4031

(1S)-1,5-脱水-1-C-[4-氯-3-[[4-[2-(环丙氧基)乙氧基]苯基]甲基]苯基]-D-山梨醇

EGFR; Potassium Channel Angiogenesis; JAK/STAT signaling; Membrane transporter/Ion channel; Tyrosine Kinase/Adaptors
E-4031是甲磺酰苯胺III 类抗心律失常药,选择性地阻断hERG 钾通道。
T0780 Pyridostigmine bromide

溴吡斯的明,Mestinon,溴化吡啶斯的明

AChE Neuroscience
Pyridostigmine bromide (Mestinon) 是一种可逆的胆碱酯酶抑制剂。
T5585 AM-92016 hydrochloride

Potassium Channel Membrane transporter/Ion channel
AM-92016 hydrochloride 是一种整流钾电流的特异性阻断剂。它能够延迟整流钾通道,使膜复极化,限制神经冲动的持续时间。
T19735 Flucycloxuron

氟螨脲,(E)-flucycloxuron,Andalin

Others Others
Flucycloxuron ((E)-flucycloxuron) 是一种甲壳素合成抑制剂,用作杀虫剂。在昆虫模型中,该抑制剂已被证明会影响几种生殖事件,例如产卵前的持续时间。
T6397 Atracurium besylate

Tracrium,51W89,BW-33A,苯磺酸阿曲库铵

AChR Neuroscience
Atracurium besylate (51W89) 是一种神经肌肉阻断剂,ED95为0.2 mg/kg。
T4250 Bilastine

比拉斯汀,Bilaxten

Histamine Receptor GPCR/G Protein; Immunology/Inflammation; Neuroscience
Bilastine (Bilaxten) 是新型抗组胺药,对H1组胺受体具有高度选择性,起效快,作用时间长的特性,可用于变应性鼻结膜炎和荨麻疹。
T1439 Lacidipine

SN-305,拉西地平,GX-1048,GR-43659X

Apoptosis; Calcium Channel; Reactive Oxygen Species Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; NF-κB
Lacidipine (SN-305) 是一种L 型钙离子通道阻断剂。
T4497 Amifampridine

3,4-Pyridinediamine,Pyridine-3,4-Diamine,阿米吡啶,3,4-Diaminopyridine

Others Others
Amifampridine (3,4-Diaminopyridine) 可用于罕见肌肉疾病的研究。
T1410 Torsemide

AC-4464,JDL-464,托拉塞米,Torasemide

Na-K-Cl cotransporter Membrane transporter/Ion channel
Torsemide (AC-4464) 是具有口服活性的亨氏环利尿剂,也具有抗醛固酮和血管舒张活性。它可用于研究心力衰竭、肾脏疾病、肝硬化。
T3574 Sematilide hydrochloride

司美利特,CK-1752A,CK-1752,Sematilide HCl

Potassium Channel Membrane transporter/Ion channel
Sematilide hydrochloride (CK-1752) 是一种选择性的 IKr 通道阻滞剂。Sematilide 以浓度依赖性抑制延迟整流钾通道 (K+current),IC50为 25 μM。Sematilide 是一种 III 类抗心律不齐剂。
T30249 AZD 7009

AZD-7009,AZD7009

Sodium Channel Membrane transporter/Ion channel
AZD 7009是一种新型抗心律失常化合物,对CHO K1细胞中 hNav1.5的钠电流具有抑制作用,IC50为11 uM。AZD 7009 对离体兔心房和心室肌细胞的晚期钠电流具有抑制作用,对e -4031诱导的动作电位持续时间延长具有抑制作用,促使浦肯野纤维的早期后去极化(EADs)。
T6541 Ibutilide Fumarate

Corvert Fumarate,U70226E,富马酸伊布利特

Calcium Channel; Sodium Channel Membrane transporter/Ion channel; Metabolism
Ibutilide Fumarate (U70226E) 是一种 III 类抗心律失常药物,可作用于急性心梗阻塞。
T1144 Lidocaine hydrochloride

Lidocaine HCL,盐酸利多卡因,Lignocaine hydrochloride,Xyloneural,Lidothesin

Apoptosis; ERK; NF-κB; MEK; Sodium Channel Apoptosis; MAPK; Membrane transporter/Ion channel; NF-κB
Lidocaine hydrochloride (Lignocaine hydrochloride) 抑制涉及复杂电压和依赖性的钠通道。它通过调节 miR-145 表达和进一步抑制 MEK/ERK 和 NF-κB 信号通路来减少胃癌细胞的生长,迁移和侵袭。Lidocaine 是一种酰胺衍生物,是一种研究室性心律失常的药物和有效的肿瘤抑制剂。
T6476 Dofetilide

UK 68789,UK-68798,Tikosyn,多非利特

Potassium Channel Membrane transporter/Ion channel
Dofetilide (UK 68789) 是一种具有口服活性、有效的且特异性的IKr 阻滞剂,作为 III 类抗心律失常药物。Dofetilide 可用于心血管疾病研究。
T1496 Amiodarone hydrochloride

盐酸胺碘酮,Amiodar,Amiodarone HCl,Nexterone

Potassium Channel; Adrenergic Receptor; Autophagy Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
Amiodarone hydrochloride (Amiodarone HCl) 是一种抗心绞痛和 III 类抗心律失常药物,通过抑制钾通道和电压门控钠通道来增加心室和心房肌肉作用的持续时间,可导致心率和血管阻力降低。它通过成纤维细胞中的 ERK1/2和 p38 MAPK 信号传导诱导细胞增殖和肌成纤维细胞分化,可研究室上性和室性心律失常。
T1281 Tropicamide

Ro 1-7683,托吡卡胺

AChR Neuroscience
Tropicamide (Ro 1-7683) 是一种选择性的 M4毒蕈碱乙酰胆碱受体拮抗剂,作为滴眼剂使用时,会产生短效瞳孔扩张和睫状肌麻痹。
T14835 BTRX-335140

CYM-53093

Opioid Receptor Endocrinology/Hormones; GPCR/G Protein; Neuroscience
BTRX-335140 (CYM-53093) 是一种有效的选择性口服活性 κ 阿片受体 (KOR) 拮抗剂,对 κOR、μOR 和 δOR 具有拮抗活性,IC50 值分别为 0.8、110 和 6500 nM。它可以很好地分布到 CNS 中,在大鼠中具有良好的体外吸收、分布、代谢、排泄和毒性以及体内药代动力学特征。
T1787 Levobupivacaine

Sodium Channel Membrane transporter/Ion channel
Levobupivacaine 是一种氨基酰胺类局麻药,属于n-alkylsubstituted pipecoloxylidide 家族。它是bupivacaine 的 S-对映异构体。
T0807 Tribromoethyl alcohol

2,2,2-Tribromoethanol,Avertin,Basibrol,Tribromoethanol,三溴乙醇,TBE

Others Others
Tribromoethyl alcohol (Avertin) 具有麻醉活性,常被用作实验动物的麻醉剂,尤其是啮齿类动物。Tribromoethyl alcohol 的麻醉时间短,麻醉起效快。
T38294 4-Deoxypyridoxine hydrochloride

S1P Receptor GPCR/G Protein
4-Deoxypyridoxine hydrochloride 通过抑制 S1P 裂解酶 (SPL) 活性来抑制细胞内 S1P 的降解,与 S1P 一样,减少化学诱导的胰岛素瘤细胞系的细胞凋亡。
T20477 Cgp 29287

Cgp29,287,Cgp29287,Cgp 29,287,Cgp-29,287,Cgp-29287

Others Others
Cgp 29287 is a primate-specific renin inhibitor. It also has a prolonged duration of action.
T11525 GW311616

Others Others
GW-311616 is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).
T27394 Furalazine

Furalazinum,Panfuran,Nifuralazinum,NFT

Others Others
Furalazine is an antimicrobial agent. Furalazine was more effective in reducing the duration of positive stool culture than chloramphenicol. It may be potentially used in the treatment of cholera.
T11525L GW311616 hydrochloride

GW311616A

Others Others
GW-311616 hydrochloride is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).
T40140 Zanamivir-Cholesterol Conjugate

Others Others
Zanamivir-cholesterol conjugate is an extended-duration neuraminidase inhibitor highly effective against drug-resistant influenza strains.
T15269 Falecalcitriol

Others Others
Falecalcitriol is an analog of calcitriol. It has a higher potency both in vivo and in vitro systems, which is longer duration of action in vivo.
T33534 Muzolimine

Edrul,Muzolimina,Muzoliminum

Others Others
Muzolimine is pyrazole diuretic with long duration and high capacity of action. It was proposed for kidney failure and hypertension but was withdrawn worldwide because of severe neurological effects.
T28567 Ro 22-9194

Ro-22-9194

Others Others
Ro 22-9194 is a class I antiarrhythmic agent. Ro 22-9194 (>=10 μM) caused a concentration-dependent decrease in the maximum upstroke velocity and shortening of action potential duration in guinea-pig ventricular cells.
T61685 Ibutilide

Others Others
Ibutilide (U70226E free base) is a potent antiarrhythmic compound that extends the action potential duration. It effectively blocks the rapidly activating delayed rectifier potassium current (I Kr ) in AT-1 cells [1].
T22315 Doxapram

Others Others
Doxapram, a central respiratory stimulant with a brief duration of action, is a selective TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel inhibitor with EC50 of 410 nM, 37 μM, 9 μM, respectively.
TP2076 [Phe8Ψ(CH-NH)-Arg9]-Bradykinin

Selective bradykinin B2 receptor agonist that is resistant to carboxypeptidase cleavage. 5-fold more potent and exhibits a more prolonged duration of action than bradykinin in vivo.
T71147 PBS-1086

Others Others
PBS-1086 is a novel dual inhibitor of the canonical and noncanonical NF-κB pathways, increasing the magnitude and duration of initial EGFR inhibitor response in multiple NSCLC models, decreasing PDHK1 expression, and suppressing phosphorylation of the PDHK1 protein substrate PDHA1 in a panel of PTEN-deficient cell lines.
T61659 CC214-2

Others Others
CC214-2 is a potent dual inhibitor of mTORC1 and mTORC2, known for its ability to impede autophagy by modulating mammalian target of rapamycin (mTOR) signaling. With this capacity, CC214-2 shows promise in shortening the duration of tuberculosis (TB) [1].
T70473 Parapenzolate Free Base

Others Others
Parapenzolate Free Base is a safe and effective anticholinergic drug possessing antisecretory and antimotility properties and prolonged duration of action. Clinical investigation has shown that after an oral dose of the drug there was inhibition of both basal and histamine-stimulated acid outputs.
T26724 AZD-9164 bromide

AZD9164,AZD-9164,AZD 9164

Others Others
AMG-221 is a potent and selective 11β-HSD1 inhibitor. AMG 221 potently blocked 11β-HSD1 activity, producing sustained inhibition for the 24-hour study duration as measured in ex vivo adipose samples. AMG-221 decreased fed blood glucose and insulin levels
T70257 Avitriptan HCl

Others Others
Avitriptan, also known as BMS-180048, is a selective 5-HT1-like receptor agonist. Avitriptan is an effective compound for the treatment of migraine headaches with a prolonged duration of response. Avitriptan Is a Ligand and Agonist of Human Aryl Hydrocarbon Receptor That Induces CYP1A1 in Hepatic and Intestinal Cells.
T80738 Z-FK-ck

Z-Phe-Lys-2,4,6-Trimethylbenzoyloxy-methylketone

Z-FK-ck (Z-Phe-Lys-2,4,6-Trimethylbenzoyloxy-methylketone) 作为一种选择性gingipain-K抑制剂,具有在剂量和时间依赖性的方式上延长血浆凝血酶时间 (TT) 的特性。
T82163 Human enteropeptidase-IN-3

Others Others
Human enteropeptidase-IN-3是一种肽类酶抑制剂,主要作用于肠肽酶,具有长效抑制功能。该化合物广泛应用于研究肠道消化相关疾病。
T41192 CNV Dopamine

Others Others
CNV Dopamine is a carboxynitroveratryl (CNV)-caged dopamine; releases dopamine upon ultraviolet light stimulation (365 nm). Induces dopaminergic currents upon photolysis in brain slices expressing wild-type or GFP-labeled D2receptors. Displays no decrease in current (rundown) with UV light flash duration of up to 100 ms. Pharmacologically inactive prior to photolysis.
T73910 Efrotomycin

Others Others
Efrotomycin 是一种口服有效的抗生素。Efrotomycin 能够从链霉菌 S.Lactamdurans 中分离得到。Efrotomycin 对感染的猪的鼠伤寒沙门氏菌数量、持续时间、脱落率和抗菌敏感性均无显著影响。

化合物

MRS-1706
Cat.No: T16136
Synonym:
Target: Adenosine Receptor
Flecainide hydrochloride
Cat.No: T8581
Synonym:
Target: Others
Procaine hydrochloride
Cat.No: T0802
Synonym: Novocaine HCl,Procaine HCl,盐酸普鲁卡因
Target: Histone Demethylase, 5-HT Receptor, DNA/RNA Synthesis, Sodium Channel, NMDAR, AChR
Procaine
Cat.No: T0029
Synonym: Duracaine,Spinocaine,普鲁卡因,Novocaine,Vitamin H3,奴夫卡因
Target: Histone Demethylase, DNA/RNA Synthesis, Sodium Channel
Mivacurium dichloride
Cat.No: T22371
Synonym: 米库氯铵,Mivacurium chloride,二氯美维库铵
Target: AChR
CyPPA
Cat.No: T20968
Synonym:
Target: Potassium Channel, Dopamine Receptor
Mephenesin
Cat.No: T0015
Synonym: Cresoxydiol,甲酚甘油醚,Memphenesin,Mephedan,Decontractyl
Target: NMDAR, iGluR
Butamben
Cat.No: T0916
Synonym: Butyl 4-aminobenzoate,4-氨基苯甲酸丁酯
Target: Potassium Channel, Calcium Channel, Sodium Channel
Soquinolol
Cat.No: T28829
Synonym: Soquinolol mucate
Target: Adrenergic Receptor
Fluorogestone acetate
Cat.No: T21335
Synonym: Flurogestone Acetate Flugestone Acetate Fluorogesterone Acetate SC9880,氟孕酮醋酸酯
Target: Others
E-4031
Cat.No: T7198
Synonym: (1S)-1,5-脱水-1-C-[4-氯-3-[[4-[2-(环丙氧基)乙氧基]苯基]甲基]苯基]-D-山梨醇
Target: EGFR, Potassium Channel
Pyridostigmine bromide
Cat.No: T0780
Synonym: 溴吡斯的明,Mestinon,溴化吡啶斯的明
Target: AChE
AM-92016 hydrochloride
Cat.No: T5585
Synonym:
Target: Potassium Channel
Flucycloxuron
Cat.No: T19735
Synonym: 氟螨脲,(E)-flucycloxuron,Andalin
Target: Others
Atracurium besylate
Cat.No: T6397
Synonym: Tracrium,51W89,BW-33A,苯磺酸阿曲库铵
Target: AChR
Bilastine
Cat.No: T4250
Synonym: 比拉斯汀,Bilaxten
Target: Histamine Receptor
Lacidipine
Cat.No: T1439
Synonym: SN-305,拉西地平,GX-1048,GR-43659X
Target: Apoptosis, Calcium Channel, Reactive Oxygen Species
Amifampridine
Cat.No: T4497
Synonym: 3,4-Pyridinediamine,Pyridine-3,4-Diamine,阿米吡啶,3,4-Diaminopyridine
Target: Others
Torsemide
Cat.No: T1410
Synonym: AC-4464,JDL-464,托拉塞米,Torasemide
Target: Na-K-Cl cotransporter
Sematilide hydrochloride
Cat.No: T3574
Synonym: 司美利特,CK-1752A,CK-1752,Sematilide HCl
Target: Potassium Channel
AZD 7009
Cat.No: T30249
Synonym: AZD-7009,AZD7009
Target: Sodium Channel
Ibutilide Fumarate
Cat.No: T6541
Synonym: Corvert Fumarate,U70226E,富马酸伊布利特
Target: Calcium Channel, Sodium Channel
Lidocaine hydrochloride
Cat.No: T1144
Synonym: Lidocaine HCL,盐酸利多卡因,Lignocaine hydrochloride,Xyloneural,Lidothesin
Target: Apoptosis, ERK, NF-κB, MEK, Sodium Channel
Dofetilide
Cat.No: T6476
Synonym: UK 68789,UK-68798,Tikosyn,多非利特
Target: Potassium Channel
Amiodarone hydrochloride
Cat.No: T1496
Synonym: 盐酸胺碘酮,Amiodar,Amiodarone HCl,Nexterone
Target: Potassium Channel, Adrenergic Receptor, Autophagy
Tropicamide
Cat.No: T1281
Synonym: Ro 1-7683,托吡卡胺
Target: AChR
BTRX-335140
Cat.No: T14835
Synonym: CYM-53093
Target: Opioid Receptor
Levobupivacaine
Cat.No: T1787
Synonym:
Target: Sodium Channel
Tribromoethyl alcohol
Cat.No: T0807
Synonym: 2,2,2-Tribromoethanol,Avertin,Basibrol,Tribromoethanol,三溴乙醇,TBE
Target: Others
4-Deoxypyridoxine hydrochloride
Cat.No: T38294
Synonym:
Target: S1P Receptor
Cgp 29287
Cat.No: T20477
Synonym: Cgp29,287,Cgp29287,Cgp 29,287,Cgp-29,287,Cgp-29287
Target: Others
GW311616
Cat.No: T11525
Synonym:
Target: Others
Furalazine
Cat.No: T27394
Synonym: Furalazinum,Panfuran,Nifuralazinum,NFT
Target: Others
GW311616 hydrochloride
Cat.No: T11525L
Synonym: GW311616A
Target: Others
Zanamivir-Cholesterol Conjugate
Cat.No: T40140
Synonym:
Target: Others
Falecalcitriol
Cat.No: T15269
Synonym:
Target: Others
Muzolimine
Cat.No: T33534
Synonym: Edrul,Muzolimina,Muzoliminum
Target: Others
Ro 22-9194
Cat.No: T28567
Synonym: Ro-22-9194
Target: Others
Ibutilide
Cat.No: T61685
Synonym:
Target: Others
Doxapram
Cat.No: T22315
Synonym:
Target: Others
[Phe8Ψ(CH-NH)-Arg9]-Bradykinin
Cat.No: TP2076
Synonym:
Target:
PBS-1086
Cat.No: T71147
Synonym:
Target: Others
CC214-2
Cat.No: T61659
Synonym:
Target: Others
Parapenzolate Free Base
Cat.No: T70473
Synonym:
Target: Others
AZD-9164 bromide
Cat.No: T26724
Synonym: AZD9164,AZD-9164,AZD 9164
Target: Others
Avitriptan HCl
Cat.No: T70257
Synonym:
Target: Others
Z-FK-ck
Cat.No: T80738
Synonym: Z-Phe-Lys-2,4,6-Trimethylbenzoyloxy-methylketone
Target:
Human enteropeptidase-IN-3
Cat.No: T82163
Synonym:
Target: Others
CNV Dopamine
Cat.No: T41192
Synonym:
Target: Others
Efrotomycin
Cat.No: T73910
Synonym:
Target: Others
Cat. No. Product Name Target Signaling Pathways
T3S0081 Oxypeucedanin

(+-)-Oxypeucedanin,氧化前胡素,Oxypeucadanin

Potassium Channel Membrane transporter/Ion channel
Oxypeucedanin ((+-)-Oxypeucedanin) 是呋喃香豆素衍生物,分离自Angelica dahurica。它是选择性开放通道阻滞剂,可抑制hKv1.5通道电流,IC50值为 76 nM。它延长心脏动作电位持续时间,是潜在的抗心律失常试剂。它通过抑制癌细胞迁移来诱导细胞凋亡。

天然产物

Oxypeucedanin
Cat.No: T3S0081
Synonym: (+-)-Oxypeucedanin,氧化前胡素,Oxypeucadanin
Target: Potassium Channel
Cat. No. Product Name Species Expression System
TMPY-04483 IRAK4 Protein, Human, Recombinant (His)

IPD1,NY-REN-64,REN64,interleukin-1 receptor-associated kinas...

Human Baculovirus Insect Cells
Interleukin-1 receptor-associated kinase 4, also known as Renal carcinoma antigen NY-REN-64, IRAK-4, and IRAK4, is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family, and Pelle subfamily. IRAK4 contains one death domain and one protein kinase domain. IRAK4 is required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. ...
TMPJ-00848 NCF1 Protein, Human, Recombinant (His)

Nox-organizing protein 2/SH3 and PX domain-containing protei...

Human E. coli
Neutrophil cytosol factor 1( NCF1) is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is characterized as a multicomponent enzyme which is activated to produce superoxide anion. NCF2, NCF1, and a membrane bound cytochrome b558 are required for the activation of the latent NADPH oxidase. The human NCF1 gene encodes a 390 amino acids protein without a signal peptide. The NCF1 gene interacts with other subunits of nicotinamide adenine dinucleotide phosphate-oxidase (NADPH) and ...
TMPY-02977 PDE1C Protein, Human, Recombinant (His & GST)

hCam-3,phosphodiesterase 1C, calmodulin-dependent 70kDa,cam-...

Human Baculovirus Insect Cells
PDE1C belongs to the cyclic nucleotide phosphodiesterase family, PDE1 subfamily. Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. PDEs are expressed ubiquitously, with each subtype having a s...
TMPY-04561 SGK3 Protein, Human, Recombinant (His & GST)

serum/glucocorticoid regulated kinase family, member 3,SGK2,...

Human Baculovirus Insect Cells
Serine / threonine-protein kinase Sgk3, also known as Serum / glucocorticoid-regulated kinase 3, Serum / glucocorticoid-regulated kinase-like and SGK3, is a cytoplasmic vesicle protein that belongs to the protein kinase superfamily and AGC Ser/Thr protein kinase family. SGK3 contains one AGC-kinase C-terminal domain, one protein kinase domain and one PX (phox homology) domain. Two specific sites of SGK3, one in the kinase domain (Thr-32) and the other in the C-terminal regulatory region (Ser-486...

重组蛋白

IRAK4 Protein, Human, Recombinant (His)
Cat.No: TMPY-04483
Species: Human
Expression System: Baculovirus Insect Cells
NCF1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00848
Species: Human
Expression System: E. coli
PDE1C Protein, Human, Recombinant (His & GST)
Cat.No: TMPY-02977
Species: Human
Expression System: Baculovirus Insect Cells
SGK3 Protein, Human, Recombinant (His & GST)
Cat.No: TMPY-04561
Species: Human
Expression System: Baculovirus Insect Cells
Cat. No. Product Name Target Signaling Pathways
TMIJ-0259 Bilastine-d6

Bilastine-d6 是 Bilastine 的氘代化合物。Bilastine 的 CAS 号为 202189-78-4。Bilastine是新型抗组胺药,对H1组胺受体具有高度选择性,起效快,作用时间长的特性,可用于变应性鼻结膜炎和荨麻疹。
TMIJ-0260 Bilastine-d4

Bilastine-d4 是 Bilastine 的氘代化合物。Bilastine 的 CAS 号为 202189-78-4。Bilastine是新型抗组胺药,对H1组胺受体具有高度选择性,起效快,作用时间长的特性,可用于变应性鼻结膜炎和荨麻疹。
T71145 Racecadotril-d5

Racecadotril-d5 is intended for use as an internal standard for the quantification of racecadotril by GC- or LC-MS. Racecadotril is a prodrug form of the neprilysin (NEP) inhibitor thiorphan. In vivo, racecadotril reduces or prevents castor oil-induced diarrhea without delaying intestinal transit in rats when administered at doses of 80 or 100 mg/kg, respectively. It also decreases the duration of diarrhea and increases body weight gain in a neonatal gnotobiotic pig model of human rotavirus-indu...
TMIJ-0497 Lacidipine-d10

Lacidipine-d10 是 Lacidipine 的氘代化合物。Lacidipine 的 CAS 号为 103890-78-4。Lacidipine 是一种L型钙离子通道阻断剂。
TMIH-0086 Amifampridine-d3 2HCl

Amifampridine-d3 2HCl 是 Amifampridine 2HCl 的氘代化合物。Amifampridine 2HCl 的 CAS 号为 54-96-6。Amifampridine 可用于罕见肌肉疾病的研究。
TMIJ-0228 Lidocaine-d6 HCl

Lidocaine-d6 HCl 是 Lidocaine HCl 的氘代化合物。Lidocaine HCl 的 CAS 号为 73-78-9。Lidocaine hydrochloride 抑制涉及复杂电压和依赖性的钠通道。它通过调节 miR-145 表达和进一步抑制MEK/ERK和NF-κB信号通路来减少胃癌细胞的生长,迁移和侵袭。Lidocaine 是一种酰胺衍生物,是一种研究室性心律失常的药物和有效的肿瘤抑制剂。
TMID-0263 Lidocaine-d10 Hydrochloride

Lidocaine-d10 Hydrochloride 是 Lidocaine Hydrochloride 的氘代化合物。Lidocaine Hydrochloride 的 CAS 号为 73-78-9。Lidocaine hydrochloride 抑制涉及复杂电压和依赖性的钠通道。它通过调节 miR-145 表达和进一步抑制MEK/ERK和NF-κB信号通路来减少胃癌细胞的生长,迁移和侵袭。Lidocaine 是一种酰胺衍生物,是一种研究室性心律失常的药物和有效的肿瘤抑制剂。
TMID-0070 Amiodarone-d10 Hydrochloride

Amiodarone-d10 Hydrochloride 是 Amiodarone Hydrochloride 的氘代化合物。Amiodarone Hydrochloride 的 CAS 号为 19774-82-4。Amiodarone hydrochloride是一种抗心绞痛和 III 类抗心律失常药物,通过抑制钾通道和电压门控钠通道来增加心室和心房肌肉作用的持续时间,可导致心率和血管阻力降低。它通过成纤维细胞中的ERK1/2和p38 MAPK信号传导诱导细胞增殖和肌成纤维细胞分化,可研究室上性和室性心律失常。
TMID-0069 Amiodarone-d4 HCl

Amiodarone-d4 HCl 是 Amiodarone HCl 的氘代化合物。Amiodarone HCl 的 CAS 号为 19774-82-4。Amiodarone hydrochloride是一种抗心绞痛和 III 类抗心律失常药物,通过抑制钾通道和电压门控钠通道来增加心室和心房肌肉作用的持续时间,可导致心率和血管阻力降低。它通过成纤维细胞中的ERK1/2和p38 MAPK信号传导诱导细胞增殖和肌成纤维细胞分化,可研究室上性和室性心律失常。

同位素标记化合物

Bilastine-d6
Cat.No: TMIJ-0259
Synonym:
Target:
Bilastine-d4
Cat.No: TMIJ-0260
Synonym:
Target:
Racecadotril-d5
Cat.No: T71145
Synonym:
Target:
Lacidipine-d10
Cat.No: TMIJ-0497
Synonym:
Target:
Amifampridine-d3 2HCl
Cat.No: TMIH-0086
Synonym:
Target:
Lidocaine-d6 HCl
Cat.No: TMIJ-0228
Synonym:
Target:
Lidocaine-d10 Hydrochloride
Cat.No: TMID-0263
Synonym:
Target:
Amiodarone-d10 Hydrochloride
Cat.No: TMID-0070
Synonym:
Target:
Amiodarone-d4 HCl
Cat.No: TMID-0069
Synonym:
Target:
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