Clomipramine-D3 hydrochloride is the deuterium-labeled Clomipramine. Clomipramine is a serotonin transporter,norepinephrine transporter dopamine transporter blocker (Ki: 0.14,54 and 3 nM).
21-Deoxycortisol is a corticosteroid metabolite of 17-hydroxyprogesterone produced in the adrenal glandvia11-hydroxylation by 11β-hydroxylase.1,2Serum levels of 21-deoxycortisol are elevated in patients with congenital adrenal hyperplasia that are heterozygous for mutations inCYP2A21, the gene encoding steroid 21-hydroxylase, and have been used as a biomarker for the detection of 21-hydroxylase deficiencies.