compartment

Metarrestin (ML246) 是一种口服有效的选择性核仁周区室 (PNC) 抑制剂，可有效抑制转移。Metarrestin 破坏核仁结构并抑制 RNA 聚合酶 (Pol) I 转录，部分是通过与翻译延伸因子 eEF1A2 的相互作用。

Osemozotan Free Base is a 5-HT(1A) receptor agonist.

SF1126 is a relevant pan and dual first-in-class PI3K BRD4 inhibitor. SF1126 is an RGDS-conjugated LY294002 prodrug, which is designed to exhibit increased solubility and bind to specific integrins within the tumor compartment.

Clinodiside A 是来自中草药Clinopodium chinensis 中。

AB05831, also known as 2-Acetamido-1,2-dideoxynojirimycin, is a highly potent and specific inhibitor of beta-hexosaminidase. N-Acetyl-3-hexosaminidase (HEX) is a member of lysosomal hydrolases, which catalyzes hydrolysis of terminal, non-reducing N-acetyl-|3-D-glucosamine (GlcNAc) andN-acetyl-(3-D-galactosamine (GalNAc) residues in glycoproteins, gan-gliosides, and glycosaminoglycans (GAGs). HEX, released by chondrocytes into the extracellular compartment, promotes cartilage matrix degradation. Osteoarthritis patients have increased HEX activity in synovial fluid.

Tyrosylprotein Sulfotransferase 2 (TPST-2) 是 TPST 的一个亚型。Tyrosylprotein Sulfotransferase 是一种 54-50 kDa 的反式高尔基网络的完整膜糖蛋白，已在几乎所有被研究的组织中发现，催化通过该隔室的可溶性蛋白和膜蛋白的酪氨酸 O-硫酸化。