chemosensitization

Stevioside 是一种天然甜味剂，从甜叶菊叶中提取的获得，具有抗癌作用。

OSS_128167 (SIRT6-IN-1) 是一种选择性沉默调节蛋白 6 (SIRT6) 抑制剂，对 SIRT6，SIRT1 和 SIRT2 的 IC50分别为 89 μM，1578 μM 和 751 μM。它具有抗 HBV、抗癌、抗炎和抗病毒活性，可抑制 HBV 的转录和复制。

Brusatol (NSC-172924) 是一种从鸦胆子植物中分离出来的天然产物，抑制Nrf2通路，可使多种癌细胞对 Cisplatin 和其他化疗药物敏感。它可开发为辅助化疗化合物，可增加细胞凋亡。

SCH900776 (MK-8776) 是一种靶向细胞周期检查点激酶 1(Chk1) 的抑制剂，IC50值为 3 nM。它比对 CDK2 和 Chk2 的选择性分别高 50 和 500 倍，具有潜在的放射增敏和化学增敏活性。

FT709 是选择性的USP9X 有效抑制剂 (IC50: 82 nM)。其中USP9X 与中心体功能、EGF 受体降解、有丝分裂期间的染色体排列、化学致敏和昼夜节律有关。

PD-321852 is a small-molecule Chk1 inhibitor, which potentiates gemcitabine-induced clonogenic death in a panel of pancreatic cancer cell lines and evaluated the relationship between endpoints associated with Chk1 inhibition and chemosensitization. Gemcitabine chemosensitization by minimally toxic concentrations of PD-321852 ranged from minimal (<3-fold change in survival) in Panc1 cells to >30-fold in MiaPaCa2 cells. PD-321852 inhibited Chk1 in all cell lines as evidenced by stabilization of Cdc25A; in combination with gemcitabine, a synergistic loss of Chk1 protein was observed in the more sensitized cell lines.

INO-1001 methanesulfonate is an isoindolinone derivative and potent inhibitor of the nuclear enzyme poly (ADP-ribose) polymerase (PARP) with chemosensitization and radiosensitization properties.