cell surface proteins

TAPI1 (TAPI) 是一种 ADAM17 TACE 抑制剂，可抑制细胞因子受体的脱落。

Glutathione arsenoxide hydrochloride (Glutathione arsenoxide hydrochloride(1271726-51-2 Free base)) 是一种潜在的抗癌活性分子和肿瘤代谢抑制剂。Glutathione arsenoxide hydrochloride 靶向线粒体内膜腺嘌呤核苷酸转移酶 (ANT)，对细胞增殖有抑制作用，促进细胞凋亡。Glutathione arsenoxide hydrochloride 可用于识别如蛋白质二硫异构酶一样的细胞表面蛋白质。

Heparan sulfate 属于天然产物，是一种线性多糖。Heparan sulfate 以蛋白多糖 (HSPG) 的形式出现，紧密附着在细胞表面或细胞外基质蛋白上。

Sulfo-NHS-Biotin (Biotin-NHS) 是一种水溶性生物素化试剂，用于生物素-链霉亲和素结合反应。 Sulfo-NHS-Biotin (Biotin-NHS) 特别适用于在链霉亲和素-生物素测定中靶向细胞表面蛋白。与链霉亲和素和固定化链霉亲和素一起使用时，可用于蛋白质检测或固定。

Influenza hemagglutinin is a type of hemagglutinin found on the surface of the influenza viruses. It is an antigenic glycoprotein. It is responsible for binding the virus to the cell that is being infected. Influenza hemagglutinin proteins bind to cells w

Nephrin is a cell surface signaling receptor protein that regulates podocyte function and plays a role in β-cell survival signaling; it is a protein necessary for the proper functioning of the renal filtration barrier. Nephrin belongs to a family of highl

BS2G crosslinker (Bis[Sulfosuccinimidyl] glutarate) is an amine reactive, water-soluble, isofunctional protein crosslinker. The molecule is impenetrable to cell membranes and can be used to label cell surface proteins.

Sulfo-egs crosslinker or ethylene glycol bis (sulfosuccinimide succinate) is a water-soluble isofunctional crosslinker that is not permeable to cell membranes and can be used to label cell surface proteins.

Sulfo-NHS-LC-Biotin, or Sulfosuccinimidyl 6-(biotinamido) Hexanoate, is a long-chain water-soluble biotinylating agent that targets cell surface proteins and is reactive to primary amine groups.

Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened. In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the Gli family. Overactivation of this pathway contributes to certain cancers, including glioblastoma, for which the Gli proteins are named. Hh antagonist VIII is a cell-permeable quinazolinyl-urea compound that has been shown to inhibit Gli transcription activity with an IC50 value of 70 nM.

Advanced glycation end products (AGEs) are compounds formed by non-enzymatic chemical reactions following the bonding of sugars to proteins or lipids during diabetes, uremia, aging, rheumatic arthritis, and other conditions. A receptor for the AGEs (RAGE) binds certain members of this class to initiate cell signaling.[1][2] Pentosidine is a well-characterized natural AGE that is often used as a biomarker for the production of all AGEs. While pentosidine can be measured in urine, the majority of this AGE is catabolized before excretion.[3] Reference：[1]. Neeper, M., Schmidt, A.M., Brett, J., et al. Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins. The Journal of Biological Chemisty 267(21), 14998-15004 (1992).[2]. Brett, J., Schmidt, A.M., Yan, S.D., et al. Survey of the distribution of a newly characterized receptor for advanced glycation end products in tissues. American Journal of Pathology 143(6), 1699-1712 (1993).[3]. Miyata, T., Ueda, Y., Horie, K., et al. Renal catabolism of advanced glycation end products: The fate of pentosidine. Kidney International 53, 416-422 (1998).

Ganglioside GM1is a monosialylated ganglioside and the prototypic ganglioside for those containing one sialic acid residue.1,2It is found in a large variety of cells, including immune cells and neurons, and is enriched in lipid rafts in the cell membrane.3It associates with growth factor receptors, including TrkA, TrkB, and the GDNF receptor complex containing Ret and GFRα, and is required for TrkA expression on the cell surface. Ganglioside GM1interacts with other proteins to increase calcium influx, affecting various calcium-dependent processes, including inducing neuronal outgrowth during differentiation. Ganglioside GM1acts as a receptor for cholera toxin, which binds to its oligosaccharide group, facilitating toxin cell entry into epithelial cells of the jejunum.4,5Similarly, it is bound by the heat-labile enterotoxin fromE. coliin the pathogenesis of traveler's diarrhea.6Ganglioside GM1gangliosidosis, characterized by a deficiency in GM1-β-galactosidase, the enzyme that degrades ganglioside GM1, leads to accumulation of the gangliosides GM1and GA1in neurons and can be fatal in infants.1Levels of ganglioside GM1are decreased in the substantia nigra pars compacta in postmortem brain from patients with Parkinson's disease.3Ganglioside GM1mixture contains a mixture of ovine ganglioside GM1molecular species with primarily C18:0 fatty acyl chain lengths, among various others. [Matreya, LLC. Catalog No. 1544] 1.Kolter, T.Ganglioside biochemistryISRN Biochem.506160(2012) 2.Mocchetti, I.Exogenous gangliosides, neuronal plasticity and repair, and the neurotrophinsCell Mol. Life Sci.62(19-20)2283-2294(2005) 3.Ledeen, R.W., and Wu, G.The multi-tasked life of GM1 ganglioside, a true factotum of natureTrends Biochem. Sci.40(7)407-418(2015) 4.Turnbull, W.B., Precious, B.L., and Homans, S.W.Dissecting the cholera toxin-ganglioside GM1 interaction by isothermal titration calorimetryJ. Am. Chem. Soc.126(4)1047-1054(2004) 5.Blank, N., Schiller, M., Krienke, S., et al.Cholera toxin binds to lipid rafts but has a limited specificity for ganglioside GM1Immunol. Cell Biol.85(5)378-382(2007) 6.Minke, W.E., Roach, C., Hol, W.G., et al.Structure-based exploration of the ganglioside GM1 binding sites of Escherichia coli heat-labile enterotoxin and cholera toxin for the discovery of receptor antagonistsBiochemistry38(18)5684-5692(1999)

SNOB 1 Reagent is a biotinylated probe for detecting S-nitrosylated proteins in a single step. S-Nitrosylated binding (SNOB) proceeds rapidly on surface proteins or cell lysates under normal physiological conditions. Proteins tagged with SNOB 1 Reagent can be analyzed using avidin-linked probes (e.g., by immunoblot) or by mass spectrometry.

Lifitegrast sodium (SAR-1118-023 sodium) 是一种小分子整合素拮抗剂，通过阻断两种重要的细胞表面蛋白（淋巴细胞功能相关抗原 1 和细胞间粘附分子 1）的结合来抑制 T 细胞介导的炎症，可减少眼表炎症，可用于研究干眼症。

Mardepodect hydrochloride (Mardepodect HCl) 是一种可穿过血脑屏障且具有口服活性的、选择性和高效性的 PDE10A 抑制剂（IC50 ：0.37 nM）。Mardepodect hydrochloride 可上调编码特定生长因子、转录因子、细胞信号分子和细胞表面蛋白的基因，同时下调广泛的可靶向细胞周期和细胞凋亡相关基因。

HA-14-1, a small molecule, binds the surface pocket of Bcl-2 proteins (IC50= ~ 9 µM), including Bcl-xl and Bcl-W, and disrupts their interaction with the Bak peptide. This action induces apoptosis by activating Apaf-1 and caspase-9 and -3. Additionally, HA-14-1 effectively induces apoptosis in human acute myeloid leukemia (HL-60) cells, with a 50 µM concentration resulting in a 90% loss of cell viability.

DPPE-PEG550 是一种用于设计共轭聚合物纳米颗粒的合成脂质体 (LPs) 的 PEG 脂质功能端基。脂质体纳米颗粒 (LNPs) 通过生物素修饰和羧基端可以进一步与其他生物分子耦合。功能化的纳米颗粒适用于特定细胞蛋白的靶向标记。以链霉亲和素作为连接体，生物素化的 PEG 脂质缀合聚合物纳米颗粒能够与细胞表面受体上的生物素化抗体结合，从而在荧光成像和传感方面具有应用价值。

DPPE-PEG750 是用于合成脂质体的 PEG 脂质功能端基，可设计用于构建共轭聚合物纳米颗粒。脂质体纳米颗粒 (LNPs) 通过生物素修饰和羧基端方便与其他生物分子耦合。功能化的纳米颗粒适用于特定细胞蛋白的靶向标记。利用链霉亲和素作为连接体，生物素化的 PEG 脂质缀合聚合物纳米颗粒能够与细胞表面受体上的生物素化抗体结合，具备基于荧光的成像和传感的应用价值。

DPPE-PEG1000 是一种用于合成脂质体 (LPs) 的 PEG 脂质功能端基，用于设计共轭聚合物纳米颗粒。脂质体纳米颗粒 (LNPs) 通过生物素修饰和羧基端，能够进一步与其他生物分子耦合。功能化的纳米颗粒可实现特定细胞蛋白的靶向标记。借助链霉亲和素连接，生物素化的 PEG 脂质缀合聚合物纳米颗粒能够结合到细胞表面受体上的生物素化抗体，展示了荧光成像和传感的实用性。

DPPE-PEG3000 是一种用于合成脂质体 (LPs) 的 PEG 脂质功能端基，用于设计共轭聚合物纳米颗粒。这些脂质体纳米颗粒 (LNPs) 通过生物素修饰和羧基端，可进一步与其他生物分子耦合。功能化后的纳米颗粒可以用于特定细胞蛋白质的靶向标记。利用链霉亲和素作为连接体，生物素化的 PEG 脂质缀合聚合物纳米颗粒能够结合到细胞表面受体上的生物素化抗体上，从而实现基于荧光的成像和传感应用。

DPPE-PEG5000 是一种用于合成脂质体 (LPs) 的 PEG 脂质功能端基，适合设计共轭聚合物纳米颗粒。脂质体纳米颗粒 (LNPs) 通过生物素修饰和羧基端，便于与其他生物分子进一步耦合。这些功能化的纳米颗粒可用于靶向标记特定细胞蛋白。借助链霉亲和素作为连接体，生物素化的 PEG 脂质缀合聚合物纳米颗粒能够与细胞表面受体上的生物素化抗体结合，从而实现基于荧光的成像和传感应用。

18:0 mPEG550 PE (ammonium) 是一种用于合成脂质体 (LPs) 的 PEG 脂质功能端基，在共轭聚合物纳米颗粒设计中有应用。脂质体纳米颗粒 (LNPs) 具有生物素修饰和羧基端，可进一步与其他生物分子耦合。功能化的纳米颗粒可以用于特定细胞蛋白的靶向标记。通过链霉亲和素作为连接体，生物素化的 PEG 脂质缀合聚合物纳米颗粒能够结合到细胞表面受体上的生物素化抗体，实现基于荧光的成像和传感。

18:0 mPEG750 PE (ammonium) 是一种用于合成脂质体(LPs)的PEG脂质功能端基，专为设计共轭聚合物纳米颗粒而制。脂质体纳米颗粒(LNPs)通过生物素修饰和羧基端可进一步与其他生物分子结合。功能性纳米颗粒用于特定细胞蛋白的靶向标记。利用链霉亲和素作为连接体，生物素化的PEG脂质缀合的聚合物纳米颗粒能够与细胞表面受体上的生物素化抗体结合，从而实现荧光成像和传感的应用。

18:0 mPEG1000 PE (ammonium) 是一种用于合成脂质体 (LPs) 的PEG脂质功能端基，用于设计共轭聚合物纳米颗粒。脂质体纳米颗粒 (LNPs) 通过生物素修饰和羧基端，能够与其他生物分子耦合。功能化的纳米颗粒适合特定细胞蛋白的靶向标记。使用链霉亲和素作为连接体，生物素化PEG脂质缀合聚合物纳米颗粒能够与细胞表面受体上的生物素化抗体结合，实现基于荧光的成像和传感应用。