18:0 mPEG550 PE (ammonium) is designed for synthesizing liposomes (LPs) with PEG lipid functional end groups, facilitating the creation of conjugated polymer nanoparticles. The liposomal nanoparticles (LNPs), modified with biotin and carboxyl ends, can further couple with various biomolecules. These functionalized nanoparticles are applicable in targeting specific cellular proteins. By utilizing streptavidin as a linker, the biotinylated PEG lipid-conjugated polymer nanoparticles can bind to biotinylated antibodies on cell surface receptors, enabling applications in fluorescence-based imaging and sensing.