18:1 PEG550 PE is utilized as a PEG lipid functional end group for synthesizing liposomes (LPs) and designing conjugated polymer nanoparticles. Liposome nanoparticles (LNPs), featuring biotin modifications and carboxyl terminals, facilitate further coupling with other biomolecules. These functionalized nanoparticles are employed for targeted labeling of specific cellular proteins. Utilizing streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles can bind to biotinylated antibodies on cell surface receptors, enabling fluorescence-based imaging and sensing applications.