adenosine 5

Adenosine 5′-diphosphoribose (ADP ribose) 由腺嘌呤和核糖通过两个磷酸基团连接而成。Adenosine 5′-diphosphoribose 是在多种细胞过程中扮演关键角色的分子，尤其是涉及 DNA 损伤反应和基因表达调控的过程中。

Adenosine 5’-methylenediphosphate is an inhibitor of ecto-5’-nucleotidase, also known as CD73, with a Kivalue of 37 nM.1It inhibits cAMP accumulation induced by adenosine 5’-monophosphate , adenosine 5’-diphosphate , or adenosine 5’-triphosphate but not adenosine in VA-13 human fibroblasts when used at a concentration of 100 μM. Adenosine 5’-methylenediphosphate reduces proliferation of U138MG glioma cells, as well as inhibits the invasion and migration of MHCC97H hepatocellular carcinoma (HCC) cells in a migration assay.2,3It increases tumor infiltration of CD3+CD8+T cells and reduces tumor growth in a K1735 murine melanoma model when administered at a dose of 400 μg mouse.4 1.Bruns, R.F.Adenosine receptor activation by adenine nucleotides requires conversion of the nucleotides to adenosineNaunyn Schmiedebergs Arch. Pharmacol.315(1)5-13(1980) 2.Braganhol, E., Tamajusuku, A.S.K., Bernardi, A., et al.Ecto-5′-nucleotidase CD73 inhibition by quercetin in the human U138MG glioma cell lineBiochim. Biophys. Acta1770(9)1352-1359(2007) 3.Shali, S., Yu, J., Zhang, X., et al.Ecto 5′ nucleotidase (CD73) is a potential target of hepatocellular carcinomaJ. Cell Physiol.234(7)10248-10259(2018) 4.Forte, G., Sorrentino, R., Montinaro, A., et al.Inhibition of CD73 improves B cell-mediated anti-tumor immunity in a mouse model of melanomaJ. Immunol.189(5)2226-2233(2021)

Adenosine 5'-phosphosulfate is an ATP and sulfate competitive inhibitor of ATP sulfurylase in humans, S. cerevisiae, and P. chrysogenum (Ki = 18, 2500, and 1500 nM, respectively). Adenosine 5'-phosphosulfate also inhibits human adenosine 5'-phosphosulfate kinase (Ki = 47.5 μM) to prevent sulfation.

Adenosine 5′-monophosphoramidate sodium is a derivative of adenosine used as an intermediate for nucleotide synthesis. It significantly influences the accumulation of cyclic AMP.

Adenosine 5’-monophosphate triethylammonium salt 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 TNU1647。

ATP dipotassium (Adenosine 5'-triphosphate dipotassium) is a vital compound involved in energy storage and metabolism within living organisms. It plays a crucial role in supplying metabolic energy for driving pumps and acts as a coenzyme in cellular processes. Additionally, ATP dipotassium functions as a significant endogenous signaling molecule contributing to immunity and inflammation.

Adenosine 5'-diphosphate disodium salt has been shown to inhibit the binding of serotonin (5-hydroxytryptamine) to 5-HT2 receptors, which are present in heart tissue.

Rp-Adenosine-5'-O-(1-thiodiphosphate)（Rp-ADP-α-S）是ADP-α-S的含硫异构体，是磷酸化酶激酶的抑制剂（Ki = 0.53 µM）。此化合物能诱导分离的人类血小板聚集（EC50 = 20 µM），并能引发经卡巴胆碱预收缩的豚鼠乙状结肠松弛（EC50 = 58.9 µM）。

Sp-Adenosine-5’-O-(1-thiodiphosphate) (Sp-ADP-α-S) 是硫含量核苷酸衍生物ADP-α-S的一种异构体。它是磷酸化酶激酶的抑制剂（Ki = 0.53 µM）。Sp-ADP-α-S能引起人类孤立血小板聚集（EC50 = 20 µM），并能使羧胺胆碱预收缩的豚鼠taenia coli松弛（EC50 = 58.9 µM）。

Rp-Adenosine-5'-O-(1-thiotriphosphate)（Rp-ATP-α-S）是一种含硫核苷酸衍生物ATP-α-S的异构体，同时也是嘌呤P2Y1受体的激动剂。在表达人类P2Y1受体的HEK293细胞中，Rp-ATP-α-S能增加钙的动员（EC50 = 75 nM）。该化合物与洗涤的人类孤立血小板结合（Ki = 156 nM），抑制由ADP引发的人类富血小板血浆（PRP）的聚集（pA2 = 4.74），并且能够抑制前列腺素E1（PGE1）在人类孤立PRP中引发的cAMP产生（pA2 = 5.26）。同时，Rp-ATP-α-S还能引起用氨基甲酰胆碱预先缩紧的豚鼠结肠条带的松弛（EC50 = 56 nM）。此外，Rp-ATP-α-S已经被用于合成被细菌核糖开关识别的环状二核苷酸。

Sp-Adenosine-5'-O-(1-thiotriphosphate) (Sp-ATP-α-S) 是一种含硫核苷酸衍生物 ATP-α-S 的异构体，也是嘌呤P2Y1受体的激动剂。在表达P2Y1受体的HEK293细胞中增加钙离子的流动（对人类受体的EC50 = 9.4 nM）。Sp-ATP-α-S 抑制了ADP诱导的孤立人类血小板聚集（Ki = 4 μM）。它还能引起经卡巴胆碱预收缩的豚鼠十二指肠松弛（EC50 = 426 nM）。

Adenosine receptor A1 antagonist 5 可作为一种腺苷拮抗剂，是一种氧嘌呤，可作为杀虫剂和虫害防治剂，对血压升高有抑制作用。

5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine, an adenosine derivative, serves as an intermediate in the synthesis of oligonucleotides.

Guanosine 5'-triphosphate-5'-adenosine, the 5′ cap analog, is a fluorescent substrate analog.

N6-Benzyl-5'-ethylcarboxamido adenosine is a selective A3 adenosine receptor agonist.

Adenosine 2',5'-diphosphate sodium is a competitive P2Y1 antagonist with non-selective antagonism at recombinant and human platelet P2X1 receptors.

N7-Methylguanosine-5'-triphosphate-5'-adenosine (m7GpppA) is a dinucleotide cap analog employed in the process of in vitro RNA transcription.

N7-Methyl-guanosine-5'-triphosphate-5'-adenosine (m7GpppA) diammonium 是体外 RNA 转录中使用的二核苷酸帽类似物。

Adenosine phosphonobutyric, 2'(3'), 5'-diposphate (APBADP) 作为一种抑制剂，对枯草芽孢杆菌 (Bacillus subtilis) 和人腺苷酸琥珀酸裂解酶 (adenylosuccinate lyase (ASL)) 具有显著的抑制作用。此外，Adenosine phosphonobutyric, 2'(3'), 5'-diposphate 还能竞争性抑制琥珀酰氨基咪唑酰胺核苷 (succinylaminoimidazole carboxamide ribotide (SAICAR))，表现出其多功能的生化应用潜力。

2',3',5'-Tri-O-acetyl adenosine is a Nucleoside.

5'-O-(4,4'-Dimethoxytrityl)-N6-Phenoxyacetyl adenosine is a 2 6 8-modified purine nucleoside.

N4-Benzoyl-5'-O-DMT-2'-O-propargyl adenosine is a Nucleoside Derivative - 2'-Modified nucleoside; Protected nucleoside with NH2 OH group.

N-Benzoyl-5'-O-dmtr-2'-O-(2-methoxyethyl)-adenosine is a Nucleoside Derivative - 2'-Modified nucleoside; Protected nucleoside with NH2 OH group.

3',5'-TIPS-N-Ac-Adenosine is a Nucleoside Derivative - Protected nucleoside with NH2 OH open.