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Targets Recommended: Apoptosis Reductase

38

抑制剂 & 化合物

1

天然产物

2

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T1499 Dutasteride

GG 745,Avodart,度他雄胺,GI 198745

Apoptosis; Reductase Apoptosis; Endocrinology/Hormones; Metabolism
Dutasteride (GI 198745) 是一种 5α 还原酶同工酶抑制剂,还可能因其结构域 DHT 相似对雄激素受体产生脱靶效应。
T76559 Survodutide

BI 456906

Glucagon Receptor GPCR/G Protein
Survodutide (BI 456906) 是一种胰高血糖素和胰高血糖素样肽 1 (GLP-1) 受体 (GLP Receptor) 双重激动剂,可降低 HbA1c16 型糖尿病的体重。
T78097L Mazdutide acetate(2259884-03-0 free base)

Mazdutide acetate(2259884-03-0 free base),OXM-3 acetate,LY-3305677 acetate,IBI-362 acetate

Glucagon Receptor GPCR/G Protein
Mazdutide acetate 是一种高效的胰高血糖素样肽 (GLP-1R) 与胰高血糖素受体 (GCGR) 的共激动剂,是一种胃泌酸调节素类似物。Mazdutide acetate可刺激小鼠胰岛的胰岛素分泌 ,可用于研究肥胖和 2 型糖尿病 (T2D) 。
T1667 Tandutinib

MLN518,CT53518,NSC726292,坦度替尼

Apoptosis; FLT; CSF-1R; PDGFR; Src; c-Kit Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
Tandutinib (CT53518) 是一种选择性 FLT3抑制剂,其 IC50为 0.22 μM。它还抑制c-Kit 和PDGFR,其IC50分别为 0.17 μM 和 0.20 μM。它可穿透血脑屏障,用于急性骨髓性白血病。
TP1103 Cotadutide acetate

MEDI0382 acetate,Cotadutide acetate (1686108-82-6 Free base)

Glucagon Receptor GPCR/G Protein
Cotadutide acetate (MEDI0382 acetate) 是一种有效的胰高血糖素样肽-1 (GLP-1) 和胰高血糖素受体肽双重激动剂,EC50 分别为 6.9 pM 和 10.2 pM。
T11128 Dutogliptin

PHX-1149 free base

Others Others
Dutogliptin (PHX-1149 free base) is an oral, effective and selective dipeptide-peptide-4 (DPP4) inhibitor for the treatment of type 2 diabetes mellitus.
T23418 Tandutinib (MLN518) HCl

Others Others
Tandutinib is an effective antagonist for FLT3, platelet-derived growth factor receptor (PDGFR), and c-Kit. Tandutinib potently inhibited the activity of FLT3, PDGFR, and c-Kit (IC50: ~200 nM).
T71693 Nepadutant

Others Others
Nepadutant 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T71693,CAS号为 183747-35-5。
T40770 5-Propargylamino-3'-azidomethyl-dUTP

Others Others
5-Propargylamino-3'-azidomethyl-dUTP is a nucleoside molecule. It finds applications in DNA synthesis and sequencing.
T76278 Efinopegdutide

Others Others
Efinopegdutide (JNJ-64565111) 是一种高效的胰高血糖素样肽-1 (GLP-1) /胰高血糖素受体 (GluR) 双重激动剂,具有同时激活GLP-1和胰高血糖素受体的能力,主要用于非酒精性脂肪性肝炎 (NASH) 的研究领域。
T16039 Ibodutant

MEN 15596

Others Others
Ibodutant is an effective and selective tachykinin NK2 receptor antagonist (pKi: 10.1).
T75385 Tetramethylrhodamine-dUTP

Others Others
Tetramethylrhodamine-dUTP (TAMRA-dUTP) 用于 DNA 的末端标记。
T11040 Dihydro Dutasteride

Others Others
Dihydro Dutasteride is a metabolite of Dutasteride. Dutasteride is an effective inhibitor of five α-reductase isozymes.
T40970 Biotin-16-dUTP

Biotin-16-dUTP,Biotin-16-deoxyuridine-5'-triphosphate

Biotin-16-dUTP is a fluorescent substitute of dTTP.
T38528 5-Propargylamino-ddUTP

5-Propargylamino-ddUTP is a nucleoside molecule employed for the synthesis of cyanine dye-nucleotide conjugates, commonly used in nucleic acid labeling and sequence analysis.
T70279 Cotadutide

Cotadutide is a dual receptor agonist that modifies the activity of glucagon and glucagon-like peptide-1 (GLP-1).
T75382 AMCA-6-dUTP

AMCA-6-dUTP AMCA-6-dUTP 可用于 DNA/cDNA 的酶标记。
T10179 5β-​Dutasteride

Others Others
5β-Dutasteride is the S configuration of Dutasteride. It is a potent inhibitor of both 5 alpha-reductase isozymes.
T39209 5-PA-dUTP

5-PA-dUTP,5-Propargylamino-dUTP

Others Others
5-PA-dUTP (5-Propargylamino-dUTP) is a modified nucleotide, specifically designed with a C5 modification. It serves the purpose of being incorporated into DNA nanoparticles (DNPs) for the efficient delivery of photosensitizers.
T74706 Vidutolimod

Others Others
Vidutolimod 是一种CpG-A 类寡核苷酸,是TLR9的激动剂。Vidutolimod 激活浆细胞样树突状细胞(pDCs)并触发IFNα的释放,导致抗肿瘤免疫作用。
T74421 Pemvidutide

Pemvidutide 是一种GLP-1R/GCGR 双重激动剂,可导致体重、肝脏脂肪和血清脂质的显著降低。Pemvidutide 可用于非酒精性脂肪性肝炎 (NASH) 和肥胖症的研究。
T64226 Tandutinib hydrochloride

Others Others
Tandutinib hydrochloride (MLN518 hydrochloride) 是一种有效和选择性的FLT3的抑制剂,其IC50为 0.22 μM,并且还抑制c-Kit 和PDGFR,其IC50分别为 0.17 μM 和 0.20 μM。Tandutinib hydrochloride 可用于急性骨髓性白血病,并具有穿越血脑屏障的能力。
T76980 Tidutamab

Tidutamab (XmAb-18087) 是一种具有完整 Fc 结构域的人源化及亲和优化双特异性抗体(bsAb),旨在通过SSTR2和CD3两个靶点特异性结合来延长血清半衰期,通过激活T细胞介导的细胞毒性(RTcC)机制,有效消除SSTR+肿瘤细胞。
T75341 Biotin-16-dUTP trisodium

Biotin-16-dUTP trisodium(Biotin-16-deoxyuridine-5'-triphosphate trisodium)可以通过酶促方式掺入DNA/cDNA中,作为其天然对应物dTTP的替代品。这种化合物主要用于生产用于多种检测应用的生物素化DNA探针。储存条件需避光。
T40969 Biotin-11-dUTP

Biotin-11-dUTP is a fluorescent substitute for dTTP.
T78097 Mazdutide

IBI-362,LY-3305677,OXM-3

Mazdutide (IBI-362; LY-3305677) 是一种具有安全性和耐受性的胃泌酸调节素类似物,用于肥胖和2型糖尿病(T2D)的研究。它同时作为胰高血糖素样肽(GLP-1R)和胰高血糖素受体(GCGR)的共激动剂,表现出长效作用。
T16842 Saredutant

SR 48968C,SR 48968

Others Others
Saredutant is an antagonist of selective NK2 receptors.
T19149 5-BrdUTP sodium salt

5-Bromo-2'-deoxyuridine 5'-triphosphate sodium salt

Others Others
5-BrdUTP sodium salt is a TdT substrate that can be used to label the DNA double-strand breaks.
T78658 Pemvidutide TFA

Others Others
Pemvidutide (TFA) 是一款针对GLP-1R/GCGR的双重激动剂,有助于显著降低体重、肝脏脂肪以及血清脂质水平。该化合物主要适用于非酒精性脂肪性肝炎(NASH)和肥胖症的研究领域。
T41104 dUTP sodium

2'-Deoxyuridine-5'-triphosphate sodium salt

Others Others
dUTP sodium is used for PCR.
T82923 Bamadutide

SAR425899

Bamadutide (SAR425899)是一种高效的GLP-1/GIP受体激动剂,主要通过增强β细胞功能和降低葡萄糖吸收速率,从而改善餐后血糖控制。该化合物适用于2型糖尿病的研究。
T76272 Pegapamodutide

Pegapamodutide (LY-2944876) 是一种glucagon-GLP-1 receptor 激动剂,可用于 2 型糖尿病和肥胖症的研究。
T80079 Mazdutide TFA

LY-3305677 TFA,IBI-362 TFA,OXM-3 TFA

Mazdutide (IBI-362; LY-3305677) TFA 是一款GLP-1R与GCGR的共激动剂,同时是长效合成胃泌酸调节素类似物。该化合物安全性和耐受性良好,适用于肥胖与T2D研究。
T78098 Survodutide TFA

BI 456906 TFA

Survodutide (BI 456906) (TFA) 为一种同时具有胰高血糖素及胰高血糖素样肽-1(GLP-1)受体激活功能的化合物。该化合物与Survodutide 具有等效性。
T19173 AA-dUTP sodium salt

Aminoallyl-dUTP sodium salt

Others Others
AA-dUTP sodium salt is a fluorescent dye which can be used to stain cDNA.
T11127 Dutogliptin tartrate

PHX-1149

Others Others
Dutogliptin tartrate is an effective and selective oral dipeptide-peptide-4 (DPP4) inhibitor for the treatment of type 2 diabetes mellitus.
T79579 ddUTP

2′,3′-Dideoxyuridine-5′-triphosphate

Reverse Transcriptase Microbiology/Virology
ddUTP (2′,3′-Dideoxyuridine-5′-triphosphate) 作为HIV与AMV逆转录酶的选择性抑制剂,其Ki为0.05 µM及1 µM。ddUTP在dTTP位点掺入生长中的DNA链,从而抑制其进一步的链延伸。
T82597 ddUTP (lithium), 100mM in H2O

2',3'-Dideoxyuridine-5'-triphosphate lithium

Nucleoside Antimetabolite/Analog Cell Cycle/Checkpoint; DNA Damage/DNA Repair
ddUTP (lithium), 100mM in H2O 是一种核酸类似物,能够被嵌入DNA、RNA或其他核酸分子中。此化合物可应用于DNA/RNA杂交实验,如Southern blots、Northern blots等。

化合物

Dutasteride
Cat.No: T1499
Synonym: GG 745,Avodart,度他雄胺,GI 198745
Target: Apoptosis, Reductase
Survodutide
Cat.No: T76559
Synonym: BI 456906
Target: Glucagon Receptor
Mazdutide acetate(2259884-03-0 free base)
Cat.No: T78097L
Synonym: Mazdutide acetate(2259884-03-0 free base),OXM-3 acetate,LY-3305677 acetate,IBI-362 acetate
Target: Glucagon Receptor
Tandutinib
Cat.No: T1667
Synonym: MLN518,CT53518,NSC726292,坦度替尼
Target: Apoptosis, FLT, CSF-1R, PDGFR, Src, c-Kit
Cotadutide acetate
Cat.No: TP1103
Synonym: MEDI0382 acetate,Cotadutide acetate (1686108-82-6 Free base)
Target: Glucagon Receptor
Dutogliptin
Cat.No: T11128
Synonym: PHX-1149 free base
Target: Others
Tandutinib (MLN518) HCl
Cat.No: T23418
Synonym:
Target: Others
Nepadutant
Cat.No: T71693
Synonym:
Target: Others
5-Propargylamino-3'-azidomethyl-dUTP
Cat.No: T40770
Synonym:
Target: Others
Efinopegdutide
Cat.No: T76278
Synonym:
Target: Others
Ibodutant
Cat.No: T16039
Synonym: MEN 15596
Target: Others
Tetramethylrhodamine-dUTP
Cat.No: T75385
Synonym:
Target: Others
Dihydro Dutasteride
Cat.No: T11040
Synonym:
Target: Others
Biotin-16-dUTP
Cat.No: T40970
Synonym: Biotin-16-dUTP,Biotin-16-deoxyuridine-5'-triphosphate
Target:
5-Propargylamino-ddUTP
Cat.No: T38528
Synonym:
Target:
Cotadutide
Cat.No: T70279
Synonym:
Target:
AMCA-6-dUTP
Cat.No: T75382
Synonym:
Target:
5β-​Dutasteride
Cat.No: T10179
Synonym:
Target: Others
5-PA-dUTP
Cat.No: T39209
Synonym: 5-PA-dUTP,5-Propargylamino-dUTP
Target: Others
Vidutolimod
Cat.No: T74706
Synonym:
Target: Others
Pemvidutide
Cat.No: T74421
Synonym:
Target:
Tandutinib hydrochloride
Cat.No: T64226
Synonym:
Target: Others
Tidutamab
Cat.No: T76980
Synonym:
Target:
Biotin-16-dUTP trisodium
Cat.No: T75341
Synonym:
Target:
Biotin-11-dUTP
Cat.No: T40969
Synonym:
Target:
Mazdutide
Cat.No: T78097
Synonym: IBI-362,LY-3305677,OXM-3
Target:
Saredutant
Cat.No: T16842
Synonym: SR 48968C,SR 48968
Target: Others
5-BrdUTP sodium salt
Cat.No: T19149
Synonym: 5-Bromo-2'-deoxyuridine 5'-triphosphate sodium salt
Target: Others
Pemvidutide TFA
Cat.No: T78658
Synonym:
Target: Others
dUTP sodium
Cat.No: T41104
Synonym: 2'-Deoxyuridine-5'-triphosphate sodium salt
Target: Others
Bamadutide
Cat.No: T82923
Synonym: SAR425899
Target:
Pegapamodutide
Cat.No: T76272
Synonym:
Target:
Mazdutide TFA
Cat.No: T80079
Synonym: LY-3305677 TFA,IBI-362 TFA,OXM-3 TFA
Target:
Survodutide TFA
Cat.No: T78098
Synonym: BI 456906 TFA
Target:
AA-dUTP sodium salt
Cat.No: T19173
Synonym: Aminoallyl-dUTP sodium salt
Target: Others
Dutogliptin tartrate
Cat.No: T11127
Synonym: PHX-1149
Target: Others
ddUTP
Cat.No: T79579
Synonym: 2′,3′-Dideoxyuridine-5′-triphosphate
Target: Reverse Transcriptase
ddUTP (lithium), 100mM in H2O
Cat.No: T82597
Synonym: 2',3'-Dideoxyuridine-5'-triphosphate lithium
Target: Nucleoside Antimetabolite/Analog
Cat. No. Product Name Target Signaling Pathways
T38427 dUTP trisodium

2'-Deoxyuridine-5'-triphosphate trisodium salt,Deoxyuridine triphosphate

DNA/RNA Synthesis Cell Cycle/Checkpoint; DNA Damage/DNA Repair
dUTP trisodium (Deoxyuridine triphosphate) 是在 5'-位具有三磷酸基团的脱氧尿苷磷酸盐,可用于 PCR。

天然产物

dUTP trisodium
Cat.No: T38427
Synonym: 2'-Deoxyuridine-5'-triphosphate trisodium salt,Deoxyuridine triphosphate
Target: DNA/RNA Synthesis
Cat. No. Product Name Species Expression System
TMPJ-00941 dUTPase Protein, Human, Recombinant (His)

Deoxyuridine 5'-Triphosphate Nucleotidohydrolase Mitochondri...

Human E. coli
dUTPase Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 20 KDa and the accession number is P33316-2.
TMPJ-00940 dUTPase Protein, Human, Recombinant

dUTPase,dUTP Pyrophosphatase,Deoxyuridine ...

Human E. coli
dUTPase Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17 KDa and the accession number is P33316-2.

重组蛋白

dUTPase Protein, Human, Recombinant (His)
Cat.No: TMPJ-00941
Species: Human
Expression System: E. coli
dUTPase Protein, Human, Recombinant
Cat.No: TMPJ-00940
Species: Human
Expression System: E. coli
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