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6

抑制剂 & 化合物

5

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T83636L NSC 122393

3,4,5,6-Tetrabromofluorescein

NSC 122393 是一种荧光染料,抑制BaxBcl-X之间相互作用,可诱导Bcl-X过表达乳腺癌细胞的凋亡。
T77332 TV 3279

BCL; PKC Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling
TV 3279是一种新型ChE-MAI 抑制剂 ,神经保护特性取决于它们诱导抗凋亡蛋白PKC、Bcl-2、Bcl-x 和SOD 的能力,并阻止促凋亡酶甘油醛磷酸脱氢酶在PC-12和神经母细胞瘤细胞中的核易位。
T26789 BH3I-2'

BH3I2',BH3I 2'

BH3I-2' is a cell-permeable BH3 mimetic. BH3I-2' induces apoptosis by specifically preventing BH3 domain-mediated interactions between pro-apoptotic and anti-apoptotic members of the Bcl-2 family, thereby blocking the interaction between Bcl-x and Bak BH3 by targeting the Bcl-x binding pocket.
T82918 BAX-IN-1

BAX-IN-1为潜在的Bcl-2相关x蛋白(BAX)选择性抑制剂。
T21786 Apogossypolone (ApoG2)

Apogossypolone (ApoG2) 是一种具有口服活性的Bcl-2 家族蛋白抑制剂,对 Bcl-2, Mcl-1 和 Bcl-XL 的Ki 值分别为 35, 25 和 660 nM。Apogossypolone 具有抗肿瘤活性,可诱导细胞凋亡 (apoptosis) 和 自噬 (autophagy)。Apogossypolone 具有抗真菌活性。
T69200 CGP74514A

CGP74514A is a CDK1 inhibitor with potential anticancer activity. In U937 cells, CGP74514A - induced apoptosis (5 microM) became apparent within 4 hr and approached 100% by 24 hr. The pan- caspase inhibitor Boc-fmk and the caspase-8 inhibitor lETD-fmk opposed CGP74514A -induced caspase-9 activation and PARP degradation, but not cytochrome c or Smac/DIABLO release. CGP74514A -mediated apoptosis was substantially blocked by ectopic expression of full-length Bel- 2, a loop-deleted mutant Bcl-2, and...

化合物

NSC 122393
Cat.No: T83636L
Synonym: 3,4,5,6-Tetrabromofluorescein
Target:
TV 3279
Cat.No: T77332
Synonym:
Target: BCL, PKC
BH3I-2'
Cat.No: T26789
Synonym: BH3I2',BH3I 2'
Target:
BAX-IN-1
Cat.No: T82918
Synonym:
Target:
Apogossypolone (ApoG2)
Cat.No: T21786
Synonym:
Target:
CGP74514A
Cat.No: T69200
Synonym:
Target:
Cat. No. Product Name Species Expression System
TMPY-02431 BCL-XL Protein, Human, Recombinant (His)

bcl-xS,PPP1R52,Bcl-X,

Human E. coli
BCL-XL Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 25.2 kDa and the accession number is A0A0S2Z3C5.
TMPY-02564 BCL-XL Protein, Mouse, Recombinant (aa 1-212, His)

bcl2-L-1,Bcl-XL,BCL2-lik...

Mouse E. coli
BCL-XL Protein, Mouse, Recombinant (aa 1-212, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 25.2 kDa and the accession number is Q64373-1.
TMPY-03974 Bim Protein, Human, Recombinant (His)

BAM,BCL2-like 11 (apoptosis facilitator),BIM,BOD

Human E. coli
BCL2L11, also known as Bim, belongs to the BCL-2 protein family. Members of this family form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BCL2L11 contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. BCL2L11 gene functions as an essential initiator of apoptosis in thymoc...
TMPY-04768 PRPS2 Protein, Human, Recombinant (His)

PRPS2,PRSII,phosphoribosyl pyrophosphate synthetase 2

Human E. coli
PRPS2, a subset of PRS, is reported to be a potential protein associated with Sertoli-cell only syndrome. PRPS2 expression correlates with Sertoli-cell only syndrome and inhibits the apoptosis of TM4 Sertoli cells via the p53/Bcl-2/caspases signaling pathway. The gene for PRS II (PRPS2) is located at a different region of the X chromosome, namely Xpter-a21. The promoter region of the human PRPS2 gene was also GC-rich and contained a TATA-like sequence, four Sp1 binding sites and a homopyrimidine...
TMPY-02001 RTN4 Protein, Human, Recombinant (GST)

UNG1,NOGO,reticulon 4,RTN4-A,Nbla00271,NOGO-A,RTN-X...

Human E. coli
Reticulon-4, also known as Foocen, Neurite outgrowth inhibitor, Nogo protein, Neuroendocrine-specific protein, Neuroendocrine-specific protein C homolog, RTN-x, Reticulon-5 and RTN4, is a multi-pass membrane protein that contains one reticulon domain. Isoform 1 of RTN4 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 of RTN4 is widely expressed except for the liver. Isoform 3 of RTN4 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 ...

重组蛋白

BCL-XL Protein, Human, Recombinant (His)
Cat.No: TMPY-02431
Species: Human
Expression System: E. coli
BCL-XL Protein, Mouse, Recombinant (aa 1-212, His)
Cat.No: TMPY-02564
Species: Mouse
Expression System: E. coli
Bim Protein, Human, Recombinant (His)
Cat.No: TMPY-03974
Species: Human
Expression System: E. coli
PRPS2 Protein, Human, Recombinant (His)
Cat.No: TMPY-04768
Species: Human
Expression System: E. coli
RTN4 Protein, Human, Recombinant (GST)
Cat.No: TMPY-02001
Species: Human
Expression System: E. coli
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