586347-97-9

PD153035 is a ATP-competitive EGFR inhibitor with an IC50 and Ki of 25 and 6 pM. PD153035 effectively blocks the enhancement of mitogenesis, induction of early gene expression, and oncogenic transformation that occur in response to EGF receptor stimulation. With human fibroblasts and epidermoid carcinoma cells, PD153035 at nanomolar concentrations rapidly inhibits EGFR autophosphorylation. With breast and ovarian cancer cells, PD153035 not only blocks cell growth via inhibition of EGFR, but also upregulates the expression of the tumor suppressor retinoic acid receptor-beta 2 (RAR-beta2).

PD153035 (NSC-669364) 是一种EGFR 抑制剂，Ki 和IC50值分别为6和25 pM。

PD153035 hydrochloride (ZM 252868) 是有效地EGFR 抑制剂，Ki 和IC50值分别为6和25 pM。