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Tempone

产品编号 T36506 CAS 2896-70-0

别名: 4-Oxo-tempo

Tempone 是一种氨基氧烷，具有自由基清除剂的作用，会与活性氧（ROS）发生反应。静脉注射 Tempone 可降低自发性高血压大鼠的平均动脉。

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Tempone, CAS 2896-70-0

规格	价格/CNY	货期
500 mg	￥ 219	现货
1 g	￥ 297	现货
5 g	￥ 1,070	现货
10 g	￥ 1,830	现货

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选择批次

纯度: 98.18%

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生物活性

化学信息

存储 & 溶解度

参考文献

产品描述

Tempone is an aminooxyalkane that acts as a free radical scavenger and reacts with reactive oxygen species (ROS). Intravenous Tempone reduces mean arterial pressure in spontaneously hypertensive rats.

体内活性

Tempone (100 mg/kg i.v. bolus followed by 30 mg/kg i.v. infusion; rats) significantly improved both glomerular and tubular function (serum urea, creatinine, creatinine clearance, and fractional excretion of Na(+)) in a dose-dependent manner and significantly attenuated the reperfusion-injury associated with I/R (urinary N-acetyl-beta-D-glucosaminidase, aspartate aminotransferase, assessment of renal histology). Tempone also markedly reduced the immunohistochemical evidence of the formation of nitrotyrosine and poly(ADP-ribose), indicating a reduction of nitrosative and oxidative stress, respectively. Importantly, in contrast to its in vivo metabolite TEMPOL (which also provided protective effects against renal I/R and oxidative stress of PT cells), Tempone reduced renal dysfunction and injury without causing a significant reduction in blood pressure upon administration. These results suggest, for the first time, that Tempone can reduce the renal dysfunction and injury caused by I/R and the injury caused to PT cells by oxidative stress without producing the adverse cardiovascular effects observed when using other nitroxyl radicals.[2]

别名	4-Oxo-tempo
分子量	170.23
分子式	C9H16NO2
CAS No.	2896-70-0

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 45 mg/mL (264.35 mM)

PBS (pH 7.2): 10 mg/mL

DMF: 30 mg/mL

Ethanol: 30 mg/mL

溶液配制表

可选溶剂	浓度体积质量	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	5.8744 mL	29.372 mL	58.7441 mL	146.8601 mL
	5 mM	1.1749 mL	5.8744 mL	11.7488 mL	29.372 mL
	10 mM	0.5874 mL	2.9372 mL	5.8744 mL	14.686 mL
	20 mM	0.2937 mL	1.4686 mL	2.9372 mL	7.343 mL
	50 mM	0.1175 mL	0.5874 mL	1.1749 mL	2.9372 mL
	100 mM	0.0587 mL	0.2937 mL	0.5874 mL	1.4686 mL

计算器

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参考文献

1. Snipes W, et al. Electron spinal resonance analysis of the nitroxide spin label 2,2,6,6-tetramethylpipidone-N-oxyl (Tempone) in single crystals of the reduced Tempone matrix. Biophys J. 1974;14(1):20-32. 2. Patel NS, et al. TEMPONE reduces renal dysfunction and injury mediated by oxidative stress of the rat kidney. Free Radic Biol Med. 2002;33(11):1575-1589.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

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第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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