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Cadralazine

Name: Cadralazine
Brand: TargetMol
SKU: T26939
Price: 176 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 卡屈嗪, ISF-2469, ISF2469, ISF 2469

货号 T26939Cas号 64241-34-5 一键复制产品信息纯度: 99.65%

很棒

Cadralazine (ISF 2469) 是一种外周小动脉血管扩张剂，可用于作为抗高血压药物的研究。

Cadralazine

一键复制产品信息

很棒

纯度: 99.65%

货号 T26939Cas号 64241-34-5

别名 卡屈嗪, ISF-2469, ISF2469, ISF 2469

Cadralazine (ISF 2469) 是一种外周小动脉血管扩张剂，可用于作为抗高血压药物的研究。

规格	价格	库存
1 mg	¥ 176	现货
5 mg	¥ 407	现货
10 mg	¥ 653	现货
25 mg	¥ 1,330	现货
50 mg	¥ 1,830	现货
100 mg	¥ 2,610	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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常见问题解答

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纯度: 99.65%

颜色: 白色

性状: Solid

资源下载: COA HNMR LCMS产品操作手册

产品介绍

Cadralazine AI Summary

Cadralazine demonstrates bioactivity in blocking the entry of the Ebola virus, with an AC50 ranging from 2.818 µM to 3162.3 nM, indicating potential inhibitory effects on the virus's entry process. Additionally, the compound exhibits antiviral activity by inhibiting SARS-CoV-2-induced cytotoxicity in both Caco-2 and Vero-6 cells. Specifically, in Caco-2 cells, Cadralazine shows a 2.11% inhibition rate at a concentration of 10 µM after 48 hours. In Vero-6 cells, the compound exhibits a 0.05% inhibition rate under similar conditions. Further, Cadralazine inhibits the SARS-CoV-2 3CL-Pro protease at a concentration of 20 µM, although it shows an inhibition percentage of -6.669%. Additionally, the compound inhibits human HDAC6 enzyme activity, showing a decrease of 12.37% in a commercial peptide substrate assay and an increase of 2.11% in a custom peptide substrate assay. Beyond these activities, Cadralazine has demonstrated a wide range of binding affinities for various receptors and enzymes, such as human ADRB2, human OPRK1, human HTR2C, and more, with AC50 values typically exceeding 30000.0 nM. It has been evaluated for inhibition of enzymes like human PTGS2 (AC50 of 2500.0 nM) and human PDE4D (AC50 greater than 30000.0 nM). The compound also shows agonist and antagonist activities for receptors including human HRH2, human ADRA2A, human HTR1A, and human DRD1, with AC50 values generally greater than 30000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Cadralazine (ISF 2469) is a peripheral arteriolar vasodilator and can be used in studies about acting as an antihypertensive drug.
别名	卡屈嗪, ISF-2469, ISF2469, ISF 2469

化学信息

分子量	283.33
分子式	C₁₂H₂₁N₅O₃
CAS No.	64241-34-5
Smiles	N(CC(C)O)(CC)C1=CC=C(NNC(OCC)=O)N=N1
密度	1.1585 g/cm3 (Estimated)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 200 mg/mL (705.89 mM), Sonication and heating to 60℃ are recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (17.65 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5295 mL	17.6473 mL	35.2945 mL	176.4727 mL
5 mM	0.7059 mL	3.5295 mL	7.0589 mL	35.2945 mL
10 mM	0.3529 mL	1.7647 mL	3.5295 mL	17.6473 mL
20 mM	0.1765 mL	0.8824 mL	1.7647 mL	8.8236 mL
50 mM	0.0706 mL	0.3529 mL	0.7059 mL	3.5295 mL
100 mM	0.0353 mL	0.1765 mL	0.3529 mL	1.7647 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。