Name: BAMEA-O16B
Brand: TargetMol
SKU: T40153
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

5 mg

¥ 1,790

35日内发货

10 mg

¥ 3,390

35日内发货

25 mg

¥ 7,900

35日内发货

50 mg

¥ 14,300

35日内发货

生物活性

产品描述	BAMEAO16B is a lipid nanoparticle that incorporates disulfide bonds for efficient delivery of Cas9 mRNA and sgRNA into cells. In the intracellular environment, BAMEAO16B responds to reduction by releasing RNA, facilitating genome editing. This compound is valuable for gene editing research purposes.
体外活性	BAMEA-O16B/Cas9 mRNA/sgHPV18 (HeLa cells) treatment significantly prohibits HeLa growth compared to that of a scramble sgRNA and Cas9 mRNA delivery. BAMEA-O16B shows RNA delivery efficiency. BAMEA-O16B shows mRNA encapsulation efficiency. BAMEA-O16B shows GFP knockout efficiency. BAMEA-O16B mediated Cas9mRNA delivery is able to regulate endogenous gene expression. BAMEA-O16B/RNA treated cells shows a higher endosome escape efficiency than that of BAMEA-O16/RNA treatment. BAMEA-O16B/RFP mRNA (HeLa cells) nanoparticles results in efficient RFP expression[1].
体内活性	BAMEA-O16B/Cas9 mRNA/sgRNA (I.v.) nanoparticle effectively knocks mouse serum proprotein convertase subtilisin/kexin type 9 (PCSK9) level down to 20% of nontreated mouse. BAMEA-O16B/Cas9 mRNA/sgPCSK9 nanoparticle reduces mouse serum PCSK9 down to 20% of that with DPBS injection or BAMEA-O16B/Cas9 mRNA/scramblesgRNA nanoparticle injections[1].
别名	BAMEA-O16B

化学信息

分子量	1114.88
分子式	C₅₆H₁₁₁N₃O₆S₆
CAS No.	2490668-30-7
Smiles	CCCCCCCCCCCCSSCCOC(=O)CCNCCN(C)CCN(CCC(=O)OCCSSCCCCCCCCCCCC)CCC(=O)OCCSSCCCCCCCCCCCC

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year 实际储存温度请以COA为准

BAMEA-O16B