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Anti-TREM-2 Antibody (6F947)
还可以产品编号 TMAY-03146
Anti-TREM-2 Antibody (6F947) 是一种 Rabbit 抗体，靶向 TREM-2。Anti-TREM-2 Antibody (6F947) 可用于 ELISA,ICC/IF。
Anti-TREM-2 Antibody (6F947)
Anti-TREM-2 Antibody (6F947)
还可以产品编号 TMAY-03146
Anti-TREM-2 Antibody (6F947) 是一种 Rabbit 抗体，靶向 TREM-2。Anti-TREM-2 Antibody (6F947) 可用于 ELISA,ICC/IF。
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抗原信息
| 产品描述 | Anti-TREM-2 Antibody (6F947) is a Rabbit antibody targeting TREM-2. Anti-TREM-2 Antibody (6F947) can be used in ELISA,ICC/IF. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 6F947 |
| 交叉反应 | Mouse |
| 验证活性 | Immunofluorescence staining of mTREM2 in RAW264.7 cells. Cells were fixed with 4% PFA,blocked with 10% serum, and incubated with rabbit anti-mouse mTREM2 monoclonal antibody (dilution ratio 1:60) at 4°C overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue).Positive staining was localized to Cytoplasm and cell membrane. |
| 应用 | ELISA,ICC/IF |
| 推荐剂量 | ELISA: 1:5000-1:10000; ICC-IF: 1:20-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse TREM-2/TREM2 (rM TREM-2/TREM2; TMPY-01703; NP_112544.1; Met1-Pro168). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the basal ganglia, corpus callosum, medulla oblongata and spinal cord, and microglial cells are the major TREM2-producing cell type in the central nervous system (CNS). TREM2 may play a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. TREM2 forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. It also associates with the signal adapter protein, DAP12, which has a cytoplasmic ITAM, leading to the subsequent activation of cytoplasmic tyrosine kinases. TREM2 is both required and sufficient for competent uptake of apoptotic neuronal cells. TREM2 and TREM2-L form a receptor-ligand pair connecting microglia with apoptotic neurons, directing removal of damaged cells to allow repair. Deficiency of the adapter protein DAP12 or its associated receptor TREM2 is associated with abnormal osteoclast development in humans. Defects in TREM2 are causes of PLOSL, also known as NHD. In addition, TREM2 signaling is also an important pathway to promote healing of wounds in the colon where stem cell replacement is necessary. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Mouse TREM-2/TREM2 Protein (TMPY-01703) |
| 抗原种属 | Mouse |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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