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Anti-NME1 Antibody (5X305)
还可以产品编号 TMAY-01938
Anti-NME1 Antibody (5X305) 是一种 Rabbit 抗体，靶向 NME1。Anti-NME1 Antibody (5X305) 可用于 IHC-P。
Anti-NME1 Antibody (5X305)
Anti-NME1 Antibody (5X305)
还可以产品编号 TMAY-01938
Anti-NME1 Antibody (5X305) 是一种 Rabbit 抗体，靶向 NME1。Anti-NME1 Antibody (5X305) 可用于 IHC-P。
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产品介绍
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偶联与修饰
抗原信息
| 产品描述 | Anti-NME1 Antibody (5X305) is a Rabbit antibody targeting NME1. Anti-NME1 Antibody (5X305) can be used in IHC-P. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 5X305 |
| 交叉反应 | Human |
| 验证活性 | 1. Immunochemical staining of human NME1 in human lung cancer with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human NME1 in human hepatoma with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). |
| 应用 | IHC-P |
| 推荐剂量 | IHC-P: 1:100-1:500 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human NME1 / NDKA (rh NME1 / NDKA; TMPY-04467; NP_000260.1; Ala2-Glu152). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | NME1, also known as Nucleoside Diphosphate Kinase A (NDK-A), or NM23-H1, belongs to the NDK family. NM23-H1 is known to have a metastasis suppressive activity in many tumor cells. Recent studies have shown that the interacting proteins with NM23-H1 which mediate cell proliferation, may act as modulators of the metastasis suppressor activity. The interacting proteins with NM23-H1 can be classified into 3 groups. The first group of proteins can be classified as upstream kinases of NM23-H1 such as CKI and Aurora-A/STK15. The second group of proteins acts as downstream effectors for the regulation of specific gene transcriptions, GTP-binding protein functions, and signal transduction in the Erk signal cascade. The third group of proteins can be classified as bi-directionally influencing binding partners of NM23-H1. As a result, the interactions with NM23-H1 and binding partners have implications in the biochemical characterization involved in metastasis and tumorigenesis. NDKA is increased in human postmortem cerebrospinal fluid (CSF), a model of global brain insult, suggesting that measurement in CSF and, more importantly, in plasma may be useful as a biomarker of stroke. Additionally, NM23-H1 significantly reduces metastasis without effects on primary tumor size and was the first discovered metastasis suppressor gene. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human NME1 / NDKA protein (TMPY-04467) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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