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Anti-IL-2 Antibody-PE (2D210)
还可以产品编号 TMAY-03742P
Anti-IL-2 Antibody-PE (2D210) 是一种 PE-conjugated Mouse 抗体，靶向 IL-2。Anti-IL-2 Antibody-PE (2D210) 可用于 FCM。
Anti-IL-2 Antibody-PE (2D210)
Anti-IL-2 Antibody-PE (2D210)
还可以产品编号 TMAY-03742P
Anti-IL-2 Antibody-PE (2D210) 是一种 PE-conjugated Mouse 抗体，靶向 IL-2。Anti-IL-2 Antibody-PE (2D210) 可用于 FCM。
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| 产品描述 | Anti-IL-2 Antibody-PE (2D210) is a PE-conjugated Mouse antibody targeting IL-2. Anti-IL-2 Antibody-PE (2D210) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG2b |
| 克隆号 | 2D210 |
| 交叉反应 | Rat |
| 验证活性 | Flow cytometric analysis of Rat IL-2 expression on SD rat splenocytes.The cells were stimulated for 4-6 hours with PMA and Ionomycin in the presence of GolgiPlug. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), stained with PE-conjugated anti-Rat IL-2 and FITC-conjugated anti-Rat CD3. The dot plots were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM |
| 推荐剂量 | 5 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rat IL2/IL-2/Interleukin-2 (rR IL2/IL-2/Interleukin-2; TMPY-02457; P17108; Ala21-Gln155) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| 研究背景 | Interleukin-2, also known as a T-cell growth factor, TCGF, Aldesleukin, and IL2, is a secreted protein that belongs to the IL-2 family. Interleukin-2 / IL-2 was the first interleukin molecule to be discovered. Interleukin-2 / IL-2 molecule was first purified to homogeneity by immunoaffinity chromatography by Kendall Smith and his team at Dartmouth Medical School. Interleukin-2 / IL-2 was also the first cytokine shown to mediate its effects via a specific IL-2 receptor, and it was also the first interleukin to be cloned and expressed from a complementary DNA (cDNA) library. Interleukin-2 / IL-2 was designated number 2 because Smith's data at the time indicated that IL-1, produced by macrophages, facilitates IL-2 production by T lymphocytes (T cells).Interleukin-2 / IL-2 is produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Interleukin-2 / IL-2 is normally produced by the body during an immune response. When environmental substances (molecules or microbes) gain access to the body, these substances (termed antigens) are recognized as foreign by antigen receptors that are expressed on the surface of lymphocytes. Antigen binding to the T cell receptor (TCR) stimulates the secretion of Interleukin-2 / IL-2 and the expression of IL-2 receptors IL-2R. The IL-2 / IL-2R interaction then stimulates the growth, differentiation, and survival of antigen-selected cytotoxic T cells via the activation of the expression of specific genes. Interleukin-2 / IL-2 can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. The World Reference Standard for Interleukin-2 / IL-2 is produced by the National Institute of Biological Standards and Control in the UK. A recombinant form of Interleukin-2 / IL-2 for clinical use is manufactured by Chiron Corporation with the brand name Proleukin. It has been approved by the Food and Drug Administration (FDA) for the treatment of cancers (malignant melanoma, renal cell cancer), and is in clinical trials for the treatment of chronic viral infections, and as a booster (adjuvant) for vaccines. The use of Interleukin-2 / IL-2 in HIV therapy is ineffective.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | PE |
| 其他可选修饰符 | APC |
| 可提供抗体种类 | 2 |
| 免疫原 | Recombinant Rat IL2/IL-2/Interleukin-2 Protein (TMPY-02457) |
| 抗原种属 | Rat |
| 研究领域 | Neuroinflammation |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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